The aim of the work is to investigate the parameters of hemostasis, electrical and viscoelastic parameters of red blood cells and markers of inflammation in persons suffering from arterial hypertension to determine the possibility of assessing the severity of hemorheological disorders.

Material and methods. The study included 203 patients (156 patients with arterial hypertension and 47 patients without hypertension). The parameters of hemostasis, markers of inflammation and red blood cells were studied.

Results. The possibilities of assessing the severity of hemorheological disorders in patients with arterial hypertension, based on the study of parameters: hemostasis, erythrocytes (by dielectrophoresis). In patients with hypertension, as the risk of venous thromboembolic complications increased, acceleration of leukocyte-platelet aggregation, increased fibrinogen level and decreased activity of XII-dependent fibrinolysis, which creates prerequisites for rheological disturbances, were revealed. The most accurate prediction of result according to severity of hemorheological disorders (differentiation moderate and expressed disorders from the lungs) is provided by such indicators of electric and viscoelastic parameters of erythrocytes, as the polarizability of red blood cells at a frequency of 106 Hz (AUC = 0,750 in), the speed of movement of cells to the electrodes (AUC = 0,746), deformation degree at a frequency of 5 × 105 Hz (AUC = 0,733), conductivity cell (AUC = 0,730), the generalized viscosity (AUC = 0,729), the index of aggregation of erythrocytes (AUC = 0,716), graduation according to the degree of strain at all frequencies (AUC = 0,716), generalized stiffness (AUC = 0,714), the deformation amplitude at frequency of 106 Hz (AUC = 0,711), the capacity of the cells (AUC = 0,693). The measure of specificity for different indices of erythrocytes is 75.4–99,3 % and a sensitivity of 84.1–98.6 %.

Conclusions. The study of the parameters of hemostasis, markers of inflammation, red blood cells allowed us to determine the key indicators for assessing the severity of hemorheological disorders in patients with arterial hypertension. The work was carried out within the framework of the budgetary theme under the State Assignment No. 121090800102-4.

In a pandemic, a special group is made up of patients with cardiovascular pathology. Cardiovascular diseases are largely associated with an increase in mortality and an increased risk of complications in patients infected with the SARS-CoV-2 virus. This determines the importance of risk stratification, the choice of optimal personalized therapy and the study of the long-term prognosis of myocardial infarction against the background of infection caused by SARS-CoV-2. Despite the rapidly growing attention to this issue, the mechanisms of the relationship between cardiovascular disease and COVID-19 are not completely clear. We conducted a systematic review to summarize important aspects of COVID-19 for cardiologists. The authors discuss both well-studied factors of the infectious process leading to acute myocardial damage and decompensation of existing chronic cardiac diseases, and new, fundamental, determining prognosis and treatment. Information on the topic was used from publications based on the PubMed, Google Scholar and eLibrary.ru databases. This work was carried out within the framework of a research grant № 67573613 of Pfizer.

The participation of platelets in the development of atherothrombosis in acute forms of cardiovascular diseases is generally recognized and well studied, while their significance in the pathogenesis of vascular atherosclerosis, starting from the earliest stages, requires further study. This article analyzes the role of platelets in the pathogenesis of atherosclerosis. Modern views on the pathogenesis of atherosclerosis, platelet-endothelial interactions, molecular mechanisms of platelet activation, platelet immune function from the point of view of the initial stages of atherogenesis, studies of the effect of antiplatelet therapy in primary and secondary prevention of atherosclerosis are considered. The leading role of platelets in the inflammatory and immune reactions of the human body is indicated, which is realized due to a complex of immune receptors, adhesion molecules and mediators.