Influence of adherence to drug treatment on indicators of physical activity in patients after myocardial infarction
https://doi.org/10.52727/2078-256X-2022-18-4-381-387
Abstract
Aim of the study: to determine the effect of adherence to drug therapy on physical activity measures, assessed by the six-minute walk test, in patients with myocardial infarction.
Methods. General physical examination methods, evaluation of medication adherence by the use of MoriskyGreen (MMAS-4) questionnaire, six minute walk test, statistical methods of data analysis.
Results. According to the results of the assessment of adherence to drug therapy, 28 patients (62.2 %) were classified as highly adherent (the Morisky – Green score was 4 points out of 4), and 17 patients (37.8 %) were low-adherent (the level less than 4 points on the Morisky – Green questionnaire). A positive correlation was found between the level of adherence to drug therapy and the distance traveled during the six-minute walk test in patients who had myocardial infarction (r = 0.345; p = 0.020).
Conclusion. The adherence to the prescribed drug therapy directly affects the indicators of physical activity of patients who have had myocardial infarction, assessed by the distance traveled during the six-minute walk test.
Supporting agencies: The study was carried out within the framework of applied scientific research in Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences “Improvement of methods for the rehabilitation of patients in the late period of myocardial infarction in Siberia”, N FWNR-2022-0028.
About the Authors
K. Yu. Nikolaev
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Konstantin Yu. Nikolaev, doctor of medical sciences, professor, head of the laboratory of emergency therapy
175/1, Boris Bogatkov srt., Novosibirsk, 630089
A. V. Akinshin
Novosibirsk State University
Russian Federation
Russian Federation
Andrey V. Akinshin, clinical resident
1, Pirogov str., Novosibirsk, 630090
E. A. Nedraga
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Elena A. Nedraga, clinical intern
175/1, Boris Bogatkov srt., Novosibirsk, 630089
G. I. Lifshitz
Institute of Chemical Biology and Fundamental Medicine
Russian Federation
Russian Federation
Galina I. Lifshitz, doctor of medical sciences, associate professor, head of the laboratory of personalized medicine
8, ave. Academician Lavrentiev, Novosibirsk, 630090
References
1. Okrugin S.A., Kuzheleva E.A., Garganeeva A.A. World Health Organization projects «Acute Myocardial Infarction Registry»: epidemiological monitoring of acute coronary catastrophes. Complex Issues of Cardio-vascular Diseases, 2018; 7 (1): 76–83. doi: 10.17802/2306-1278-2018-7-1-76-83 (In Russ.)
2. Xu J., Murphy S.L., Kochanek K.D., Bastian B.A. Deaths: Final Data for 2013. Natl. Vital. Stat. Rep., 2016 Feb 16; 64 (2): 1–119.
3. Tuppin P., Neumann A., Danchin N., de Peretti C., Weill A., Ricordeau P., Allemand H. Evidencebased pharmacotherapy after myocardial infarction in France: adherence-associated factors and relationship with 30-month mortality and rehospitalization. Arch. Cardiovasc. Dis., 2010; 103 (6-7): 363–375. doi: 10.1016/j.acvd.2010.05.003
4. Pietrzykowski Ł., Michalski P., Kosobucka A., Kasprzak M., Fabiszak T., Stolarek W., Siller-Matula J.M., Kubica A. Medication adherence and its determinants in patients after myocardial infarction. Sci. Rep., 2020; 10 (1): 12028. doi: 10.1038/s41598-020-68915-1
5. Uysal H., Ozcan Ş. The effect of individual education on patients’ physical activity capacity after myocardial infarction. Int. J. Nurs. Pract., 2015; 21 (1): 18–28. doi: 10.1111/ijn.12193
6. Bubnova M.G., Persiyanova-Dubrova A.L. Six-minute walk test in cardiac rehabilitation. Cardiovascular Therapy and Prevention, 2020; 19 (4): 2561. (In Russ.) doi: 10.15829/1728-8800-2020-2561
7. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am. J. Respir. Crit. Care Med., 2002; 166 (1): 111–117. doi: 10.1164/ajrccm.166.1.at1102
8. Morisky D.E., Green L.W., Levine D.M. Concurrent and predictive validity of a self-reported measure of medication adherence. Med. Care, 1986; 24 (1): 67–74. doi: 10.1097/00005650-198601000-00007
9. Presseau J., Schwalm J.D., Grimshaw J.M., Witteman H.O., Natarajan M.K., Linklater S., Sullivan K., Ivers N.M. Identifying determinants of medication adherence following myocardial infarction using the Theoretical Domains Framework and the Health Action Process Approach. Psychol Health, 2017; 32 (10): 1176–1194. doi: 10.1080/08870446.2016.1260724
10. Mathews R., Peterson E.D., Honeycutt E., Chin C.T., Effron M.B., Zettler M., Fonarow G.C., Henry T.D., Wang T.Y. Early Medication Nonadherence After Acute Myocardial Infarction: Insights into Actionable Opportunities From the TReatment with ADP receptor iNhibitorS: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) Study. Circ. Cardiovasc. Qual. Outcomes., 2015; 8 (4): 347–356. doi: 10.1161/CIRCOUTCOMES.114.001223
Review
For citations:
Nikolaev K.Yu., Akinshin A.V., Nedraga E.A., Lifshitz G.I. Influence of adherence to drug treatment on indicators of physical activity in patients after myocardial infarction. Ateroscleroz. 2022;18(4):381-387. (In Russ.) https://doi.org/10.52727/2078-256X-2022-18-4-381-387
Views:
232
Email this article 