Polymorphism taqib (rs708272) gene protein cholesterol ester transfer (CETP) in women with autoimmune thyroiditis with the result of hypothyroidism
Abstract
Objective: To study the polymorphism TaqIB (rs708272) gene protein cholesterolоl ester transfer (CETP) in women with autoimmune thyroiditis.
Materials and Methods: We examined 98 women with autoimmune thyroiditis, mean age 55.2 ± 7.8 years, disease duration 8.0 ± 6.4 years, menopause duration 6.4 ± 3.5 years. The average dose of L-thyroxine 84.3 ± 28.5. Control group consisted of 135 women of similar age without thyroid pathology. Polymorphism of TaqIB (rs708272) CETP gene formed by PCR RFLP on published by technique.
Results: As a result, it was found that in the group of women with AIT В1В1 and В2В2 genotypes determined in 37.8 % and 21.4 %. Win В1В2 heterozygotes in patients with hypothyroidism compared with the control group was significantly lower: 40.8 % and 54.8 %, p = 0.035. Average levels of total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides were not significantly different in carriers of different genotypes of TaqIB polymorphism (rs708272) CETP gene in the two groups.
About the Authors
O. D. Rymar
RAMS
Russian Federation
Russian Federation
SB RAMS
Institution of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
V. N. Maksimov
RAMS
Russian Federation
Russian Federation
SB RAMS
Institution of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
Yu. А. Malyshenko
RAMS
Russian Federation
Russian Federation
SB RAMS
Institution of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
N. P. Tatarnikova
RAMS
Russian Federation
Russian Federation
SB RAMS
Institution of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
E. V. Shakhtshneider
RAMS
Russian Federation
Russian Federation
SB RAMS
Institution of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
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Review
For citations:
Rymar O.D., Maksimov V.N., Malyshenko Yu.А., Tatarnikova N.P., Shakhtshneider E.V. Polymorphism taqib (rs708272) gene protein cholesterol ester transfer (CETP) in women with autoimmune thyroiditis with the result of hypothyroidism. Ateroscleroz. 2014;10(1):6-10. (In Russ.)
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