Preview

Ateroscleroz

Advanced search

Dyslipidemia – important prognostic unfavorable course risk factor of multifocal atherosclerosis in man after carotid endarterectomy

Abstract

   156 man, who were in the surgical department for subsequent reconstructive operation of carotid arteries, were analyzed. Depending on long-term one-year prognosis all patients have been divided into two groups: with unfavorable (93 individuals – 59.6 %) and favorable (63 individuals – 40.4 %) prognosis. It is proved that cardiovascular complications risk such as stroke, transient ischemic attack, myocardial infarction, patients death, and courses deterioration of multifocal atherosclerosis in any arterial region, increase or clinical presentations onset of ischemia in any organ during the first year after surgical procedure increases if there is dyslipidemia in preoperative period, pathologic value of ankle-brachial index (less than 0.9), besides intraoperative characteristic of atherosclerotic plaque (occurrence of intraplaque haemorrhage and extent of atherosclerotic plaque more than 2 cm) in patients. But among this prognostic factors the most important one is the dyslipidemia, herewith statistic regression coefficient of which is 4.64 and Wald index is 43.1. All these data determine maximal prognostic value of dyslipidemia versus other risk factors.

About the Authors

A. V. Frolov
RAMS; Russian Ministry of Health
Russian Federation

SB RAMS

Federal State Budgetary Institution "Research Institute of Complex Problems of Cardiovascular Diseases"

650002

Pine Boulevard, 6

State Budgetary Educational Institution of Higher Professional Education "Kemerovo State Medical Academy"

650029

st. Voroshilov, 22a

Kemerovo



O. L. Barbarash
RAMS
Russian Federation

SB RAMS; Russian Ministry of Health

Federal State Budgetary Institution "Research Institute of Complex Problems of Cardiovascular Diseases"

650002

Pine Boulevard, 6

State Budgetary Educational Institution of Higher Professional Education "Kemerovo State Medical Academy"

650029

st. Voroshilov, 22a

Kemerovo



References

1. Бокерия Л. А. Хирургическая тактика при сочетанном поражении коронарных и сонных артерий / Л. А. Бокерия [и др.] // Анналы хирургии. – 2011. – № 2. – С. 59–63.

2. Eckstein H. H. Evidence-based management of carotid stenosis: recommendations from international guidelines // J. Cardiovasc. Surg. 2012. Vol. 53. P. 3–13.

3. Кузнецов А. Н. Современные принципы лечения мультифокального атеросклероза / А. Н. Кузнецов // Вестник Национального медико-хирургического центра имени Н. И. Пирогова. – 2008. – № 1. – С. 78–83.

4. Чернявский А. М. Хирургическое лечение мультифокального атеросклероза / А. М. Чернявский [и др.] // Бюл. СО РАМН. – 2006. – № 2. – С. 126–131.

5. Оганов Р. Г. Национальные рекомендации ВНОК – кардиоваскулярная профилактика / Р. Г. Оганов // Кардиоваскулярная терапия и профилактика (Приложение 2). – 2011. – № 6. – С. 1–64.

6. Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза. Российские рекомендации. – IV пересмотр. – Разработаны Комитетом экспертов ВНОК // Кардиоваскулярная терапия и профилактика. – 2009. – № 6. – С. 1–58.

7. Fowkes F. G., Murray G. D., Butcher I. et al. Anklebrachial index collaboration, ankle-brachial index combined with Framingham risk score to predict cardiovascular events and mortality: a meta-analysis // JAMA. 2008. Vol. 300. P. 197–208.

8. Kurra V., Lieber M. L., Sola S. et al. Extent of thoracic aortic atheroma burden and long-term mortality after cardiothoracic surgery: a computed tomography study // JACC Cardiovasc. Imaging. 2010. Vol. 3. P. 1020–1029.

9. Cobble M., Bale B. Carotid intima-media thickness: knowledge and application to everyday practice // Postgrad. Med. 2010. Vol. 122. P. 10–80.

10. Papathanasiou A., Toumpoulis I. K., Milionis H. J. et al. Statin therapy is associated with reduced total and cardiovascular mortality after coronary artery bypass grafting surgery // Coron. Artery Dis. 2008. Vol. 19. P. 619–625.

11. Gaspardone A., Arca M. Atorvastatin: its clinical role in cerebrovascular prevention // Drugs. 2007. Vol. 67. P. 55–62.

12. Heyer E. J., Mergeche J. L., Bruce S. S. et al. Statins reduce neurologic injury in asymptomatic carotid endarterectomy patients // Stroke. 2013. Vol. 44. P. 1150–1152.


Review

For citations:


Frolov A.V., Barbarash O.L. Dyslipidemia – important prognostic unfavorable course risk factor of multifocal atherosclerosis in man after carotid endarterectomy. Ateroscleroz. 2013;9(3-4):5-11. (In Russ.)

Views: 225


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2078-256X (Print)
ISSN 2949-3633 (Online)