Preview

Ateroscleroz

Advanced search

Functional state of thyroid gland and lipid blood profile

Abstract

   Current study was performed within the HAPIEE project “Determinants of cardiovascular diseases in Eastern Europe”. Population-based subsample of 280 subjects was analyzed. Screenning of TG pathology revealed 16 women with subclinical hypothyroidism, control group composed of 32 women with euthyriodism was developed by the random numbers method. The received data showed that the total cholesterol level and hs-LDLP were significantly higher comparing with women without TG abnormalities. Characteristics of vessel wall rigidity (augmentation index in women treated for hypothyroidism or thyrotoxicosis) were similar in participants and control group.

About the Authors

S. V. Mustafina
RAMS
Russian Federation

SB RAMS

Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy

Novosibirsk



O. D. Rimar
RAMS
Russian Federation

SB RAMS

Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy

Novosibirsk



G. I. Simonova
RAMS
Russian Federation

SB RAMS

Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy

Novosibirsk



Yu. I. Ragino
RAMS
Russian Federation

SB RAMS

Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy

Novosibirsk



S. S. Kuznetsov
RAMS
Russian Federation

SB RAMS

Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy

Novosibirsk



L. V. Scherbakova
RAMS
Russian Federation

SB RAMS

Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy

Novosibirsk



S. K. Malyutina
RAMS
Russian Federation

SB RAMS

Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy

Novosibirsk



References

1. Duntas L. H. Lipoprotein (a) and apolipoprotein(a) isoform size in thyroid disease: the quest for the golden fleece // Thyroid. 2003. Vol. 13. P. 345–346.

2. Dredecjus M., Masson D., Gautier X. et al. Low cholesterol ester transfer protein (CETP) concentration, normal CETP activity in serum from patients with shortterm hypothyroidism. Lack of relationship to lipoprotein abnormalities // Clin. Endocrinol. – 2003. Vol. 58. P. 581–588.

3. Tan K. C., Shiu S. W., Kung A. W. Plasma cholesterol ester transfer protein activity in hyper- and hypothyroidism // J. Clin. Endocrinol. Metab. 1998. Vol. 83. P. 109–112.

4. Duntas L. H., Mantzou E., Koutras D. A. Circulating levels of oxidized low-density lipoprotein in overt and mild hypothyroidism // Thyroid. 2002. Vol. 12. P. 1003–1007.

5. Grover G. J., Mellstrom K., Ye L. et al. Selective thyroid hormone receptor - beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardioascular liability // Proc. Nat. Acad. Sci. USA. 2003. Vol. 100. P. 10067–10072.

6. Bakker S. J., Maaten J. C., Popp-Snijders C. et al. The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in euthyroid subjects // J. Clin. Endocrinol. Metab. 2001. Vol. 86. P. 1206–1211.

7. Abrams J. J., Grundy S. M. Cholesterol metabolism in hypothyroidism and hyperthyroidism in man // J. Lipid. Research. 1981. Vol. 22. P. 323–338.

8. Левина Л. И. Сердце при эндокринных заболеваниях / Л. И. Левина. – М.: Медицина, 1989. – 78 с.

9. Дедов И. И. Клинические критерии, гормональные и биохимические маркеры в диагностике и лечении эндокринопатий / И. И. Дедов, Г. А. Мельниченко // Современная лаборатория глазами клиницистов. – М., 1995. – С. 48–70.

10. Caron P., Calazel С., Parra H. J. et al. Decreased HDL cholesterol in subclinikal hypothyroidism: the effect of L-thyroxine therapy // J. Clin. Endocrinol. 1990. Vol. 33. P. 519–523.

11. Althaus B. U., Staub J. J., De Luche A. R. et al. LDL / HDL-changes in subclinical hypothyroidism: possible risk factors for coronary artery disease // Clin. Endocrinol. 1988. Vol. 28. P. 157–163.

12. Park K. W., Dai H. B., Ojamaa K. et al. The direct vasomotor effect of thyroid hormones on rat skeletal muscle resistance arteries // Anesth. Analg. 2002. Vol. 85. P. 734–738.

13. Kung A. W., Pang R. W. C., Janus E. D. Elevated serum lipoprotein (a) in subclinical hypothyroidism // Clin. Endocrinol. 1995. Vol. 43. P. 445–449.

14. Vierhapper H., Nardi A., Grosser P. et al. Low density lipoprotein cholesterol in subclinical hypothyroidism // Thyroid. 2000. Vol. 10. P. 981–984.

15. Pirich C., Mullner M., Sinzinger H. Prevalence and relevance of thyroid dysfunction in 1.922 cholesterol screening participants // J. Clin. Epidemiol. 2000. Vol. 53. P. 623–629.

16. Klein I., Ojamaa K. Thyroid hormone. Targeting the vascular smooth muscle cell // Circ. Res. 2001. Vol. 88. P. 260–263.

17. Mya M. M., Aronow W. S., Gerontol J. et al. Subclinical hypothyroidism is associated with coronary arterial disease in older persons // Sci. Med. Sci. 2002. Vol. 57. P. 658–659.

18. Vanderpump M. P., Tunbridge W. M. Epidemiology and prevention of clinical and subclinical hypothyroidism // Thyroid. 2002. Vol. 12. P. 839–847.

19. Сыч Ю. П. Нарушение липидного обмена при субклиническом гипотиреозе / Ю. П. Сыч [и др.] // Пробл. эндокринологии. – 2004. – Т. 50, № 3. – С. 48–51.

20. Nichols W. W. Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms // Am. J. Hypertension. 2005. Vol. 18. P. 3–10.


Review

For citations:


Mustafina S.V., Rimar O.D., Simonova G.I., Ragino Yu.I., Kuznetsov S.S., Scherbakova L.V., Malyutina S.K. Functional state of thyroid gland and lipid blood profile. Ateroscleroz. 2010;6(2):15-19. (In Russ.)

Views: 322


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2078-256X (Print)
ISSN 2949-3633 (Online)