Association of polymorphism apolipoprotein A1 with the lipid profile serum
Abstract
Objective: to investigate apolipoprotein AI gene polymorphism and its associations with lipid profile in Caucasian population of West Siberia. The study included 100 persons with total cho lesterol >300 mg/dl, 100 – with total cholesterol < 200 mg/dl) and 100 – with total cholesterol 233,6 ± 47,7 mg/dl aged 45–64 from sample of Novosibirsk population. The apolipoprotein A1 polymorphism was analyzed by standard method using PCR. The serum lipid levels were determined by standard enzymatic assays. Analysis of promoter polymorphism apolipoprotein A1 (APOAI) gene in three groups showed statistical significance associations between - 75G > А of APOAI gene and some key lipid risk factors (total blood cholesterol, low density lipoproteins cholesterol, index of atherogenity) in people of West-Siberian region. The genotype AA has been associated with higher blood lipid levels in population of West Siberia.
About the Authors
E. V. Schakhtschneider
RAMS
Russian Federation
Russian Federation
SB RAMS
Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy
Novosibirsk
I. V. Kulikov
RAMS
Russian Federation
Russian Federation
SB RAMS
Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy
Novosibirsk
M. V. Ivanova
RAMS
Russian Federation
Russian Federation
SB RAMS
Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy
Novosibirsk
M. I. Voevoda
RAMS
Russian Federation
Russian Federation
SB RAMS
Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy
Novosibirsk
References
1. Титов В. Н. Клиническая биохимия жирных кислот, липидов и липопротеинов / В. Н. Титов. – М.: Триада, 2008. – С. 42–43, 171–172.
2. Fielding C. J., Fielding P. E. Molecular physiology of reverse cholesterol transport // J. Lipid Res. 1995. Vol. 36. P. 211–228.
3. Zhu X., Wu G., Zeng W. Cysteine mutants of human apolipoprotein A-I: a study of secondary structural and functional properties // J. Lipid Res. 2005. Vol. 46. P. 1303–1311.
4. Chiesa G., Sirtori C. R. Apolipoprotein A-I (Milano): current perspectives // Curr. Opin. Lipidol. 2003. Vol. 14. P. 159–163.
5. Smith J. D., Brinton E. A., Breslow J. L. Polymorphism in the human apolipoprotein A-I gene promoter region: association of the minor allele with decreased production rate in vivo and promoter activity in vitro // J. Clin. Invest. 1992. Vol. 89. P. 1796–1800.
6. Meng Qing-He, Pajukanta P., Valsta L. Influence of apolipoprotein A-1 promoter polymorphism on lipid levels and responses to dietary change in Finnish adults // J. Internal Medicine. 1997. Vol. 241. P. 373–378.
7. Ordovas J. M., Corella D., Cupples L. A. et al. Tucker Polyunsaturated fatty acids modulate the effects of the APOAI G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study // Am. J. Clin. Nutr. 2002. Vol. 75. P. 38–46.
8. Reguero J. R., Cubero G. I., Batalla A. et al. Apolipo protein A1 gene polymorphisms and risk of early coronary disease // Cardiology. 1998. Vol. 90. P. 231–235.
9. Barre D. E., Guerra R., Verstraete R. et al. Genetic analysis of a polymorphism in the human apolipoprotein A-1 gene promoter: effect on plasma HDL-cholesterol levels // J. Lipid Res. 1994. Vol. 35. P. 1292–1296.
10. Al-Yahyaee, Said Ali S., Al-Kindi et al. Аpolipoprotein A1 -75 G/A (M1-) polymorphism and Lipoprotein(a); Anti- vs. Pro-Atherogenic properties // Lipids in Health and Disease. 2007. Vol. 6. P. 19–25.
11. Chen E. S. Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity // Clin. Exp. Med. 2009. Vol. 6. P. 32–36.
12. Schoonjans K., Martin G., Staels B. Peroxisome proliferator-activated receptors, orphans with ligands and functions // Curr. Opin. Lopidol. 1997. Vol. 8. P. 159–166.
13. McPherson R., Agnani G., Lau P. Role of Lp A-I and Lp A-I/A-II in cholesteryl ester transfer protein-mediated neutral lipid transfer: studies in normal subjects and in hypertriglyceridemic patients before and after fenofibrate therapy // Arterioscler. Thromb. Vasc. Biol. 1996. Vol. 16. P. 1340–1346.
14. Смит К. Анализ генома / К. Смит, С. Калко, Ч. Кантор ; Под ред. К. Дейвиса (пер. с англ.). – М.: Мир, 1990. – С. 58–94.
Review
For citations:
Schakhtschneider E.V., Kulikov I.V., Ivanova M.V., Voevoda M.I. Association of polymorphism apolipoprotein A1 with the lipid profile serum. Ateroscleroz. 2010;6(2):5-9. (In Russ.)
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