DETERMINANTS OF CENTRAL AORTIC PRESSURE, AUGMENTATION AND AMPLIFICATION IN THE GENERAL POPULATION OF NOVOSIBIRSK

Objective. Currently increasing attention to the parameters of central aortic pressure (cAP). The study associations of cAP, its augmentation and amplification, with a number of metabolic parameters in the general population of Novosibirsk is of interest. Material and methods. The study involved 327 people: 155 men and 172 women aged 25-44 years from a representative sample of the general population of Novosibirsk. The research program included anthropometry, blood pressure measurement and biochemical analysis of blood serum. Central hemodynamic parameters were determined using SphygmoCor system. Metabolic syndrome components were determined according to the criteria of RSC 2009. We used the methods of descriptive statistics and analysis of data in the general linear model (GLM). Results. Systolic cAP was associated with waist circumference, triglycerides and blood glucose levels independently of other metabolic parameters, sex, age, height and heart rate. Diastolic cAP was associated with the waist circumference, triglycerides, blood glucose and low density lipoproteins levels. Triglycerides level was also associated with central augmented pressure, heart rate corrected central augmented pressure and non augmented amplification of systolic pressure. Central aortic hypertension was associated with abdominal obesity and hypertriglyceridemia, regardless of other metabolic syndrome components, sex, age, height and heart rate. Central aortic pressure in persons with abdominal obesity was 109/79 mm Hg, in the group of persons with hypertriglyceridemia - 110/78 mm Hg. Conclusion. In the general population of Novosibirsk residents 25-44 years independent determinants of central aortic pressure were waist circumference, triglycerides, low density lipoproteins and blood glucose levels. Triglycerides level was also independently associated with central augmented pressure, heart rate corrected central augmented pressure and non augmented amplification of systolic pressure. Central aortic hypertension was independently associated with abdominal obesity and hypertriglyceridemia.

central aortic pressure, augmentation, amplification, metabolic syndrome

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