Lipid profile indices in young people with different types of diabetes mellitus
https://doi.org/10.52727/2078-256X-2022-18-3-230-235
Abstract
Of all types of diabetes mellitus (DM), type 1 diabetes mellitus (DM1) and type 2 diabetes (DM2) are most often diagnosed in young people. However, up to 10 % of all cases of DM diagnosed at a young age are monogenic forms of DM – MODY (Maturity-Onset Diabetes of the Young), the most common forms of which are MODY2 (GCK-MODY) and MODY3 (HNF1AMODY). These genetic forms of DM are poorly understood, so the investigation of their clinical and biochemical parameters, including lipid profile, and comparison with more studied forms of DM is of high importance. The aim of this study was to analyze the characteristics of the lipid profile in patients aged 18–45 years with DM1, DM2, GCK-MODY and HNF1A-MODY.
Material and methods. In 56 patients diagnosed by the molecular genetic method MODY, as well as in 82 patients with DM2 and 14 patients with DM1, matched by sex, age, a lipid profile was studied.
Results. There were no statistically significant differences in total cholesterol and low-density lipoprotein cholesterol between young patients with different types of DM. In HNF1a-MODY, the highest level of triglycerides was revealed; in DM1, the level of high-density lipoprotein cholesterol was significantly higher than in other types of DM. Among the changes in the lipid profile among all types of DM, hypercholesterolemia was more often determined.
Supporting agencies: The work was carried out within the framework of the grant of the President of the Russian Federation for state support of young Russian scientists – doctors of sciences MD-3017.2022.3 and budgetary theme of the State assignment reg. № 122031700094-5
About the Authors
A. K. Ovsyannikova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Alla K. Ovsyannikova - doctor of medical sciences, senior researcher, laboratory of clinical-population and preventive research of therapeutic and endocrine diseases.
175/1, Boris Bogatkov str., Novosibirsk, 630089
V. I. Alferova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Vlada I. Alferova - junior researcher of laboratory of genetic and environmental determinants of the human life cycle.
175/1, Boris Bogatkov str., Novosibirsk, 630089
O. D. Rymar
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Oksana D. Rymar - doctor of medical sciences, senior researcher, director of laboratory of clinical-population and preventive research of therapeutic and endocrine diseases.
175/1, Boris Bogatkov str., Novosibirsk, 630089
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Review
For citations:
Ovsyannikova A.K., Alferova V.I., Rymar O.D. Lipid profile indices in young people with different types of diabetes mellitus. Ateroscleroz. 2022;18(3):230-235. (In Russ.) https://doi.org/10.52727/2078-256X-2022-18-3-230-235
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