Lipid-metabolic risk factors of chronic non-communicable diseases among patients with gastroesophageal reflux disease

   Lipid and metabolic risk factors for chronic noninfectious diseases for Yakuts with gastroesophageal reflux disease (GERD) and metabolic syndrome (MS) assessment work was carried out. A cross-sectional study of 140 patients with GERD was done. Depending on the MS availability and ethnicity, patients were divided into 3 groups. The main group included 50 Yakut nationality patients with GERD and MS. The comparison group I consisted of 50 Yakuts with GERD and without MS, the comparison group II consisted of 40 Russian GERD and MS. Preliminary verification of the diagnosis of GERD was done according to the Mayo Clinic and the Montreal Consensus (2006). The components of MS were determined on the basis of the recommendations of the All-Russian Scientific Society of Cardiology from 2009. Statistical processing and analysis of data was performed using the package IBM SPSS Statistics 19. Pair comparison was performed using the Mann-Whitney test. To assess the association of clinical symptoms of GERD with components of MS was used binary logistic regression method with forced inclusion of predictors. Analysis of lipid metabolic risk factors for chronic noninfectious diseases for Yakuts with gastroesophageal reflux disease and metabolic syndrome showed that sistolic and diastolic blood pressure, total cholesterol, LDL, triglycerides and the atherosclerotic index in patients with GERD and MS are characterized by high rates during normal value high density lipoprotein cholesterol. Triglyceride levels in Yakuts with MS are above recommended values, but at the same time as compared to the same period at the Russian MS were significantly lower. Assessment of the relationship of clinical symptoms of GERD with the criteria of MS in people of Yakut nationality showed the contribution of components of MS, especially abdominal obesity, high blood pressure and triglycerides, in the development of dyspeptic symptoms (bloating, heaviness in the epigastric), esophageal (epigastric burning) and extraesophageal symptoms (nocturnal cough) of GERD .

1. Nilsson M., Johnsen R., Ye W. et al. Obesity and estrogen as risk factors for gastroesophageal reflux symptoms // JAMA. 2003. Vol. 290. P. 66–72.

2. Hampel H., Abraham N. S., El-Serag H. B. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications // Ann. Intern. Med. 2005. Vol. 143. P. 199–211.

3. Wu J. C., Mui L. M., Cheung C. M. et al. Obesity is associated with increased transient lower esophageal sphincter relaxation // Gastroenterology. 2007. Vol. 32. P. 883–889.

4. Sise A., Friedenberg F. K. A comprehensive review of gastroesophageal reflux disease and obesity // Obes. Rev. 2008. Vol. 9. P. 194–203.

5. Lee Y. C., Yen A. M., Tai J. J. et al. The effect of metabolic risk factors on the natural course of gastrooesophageal reflux disease // Gut. 2009. Vol. 58. P. 174–181.

6. Moki F., Kusano M., Mizuide M. et al. Association between reflux oesophagitis and features of the metabolic syndrome in Japan // Aliment. Pharmacol. Ther. 2007. Vol. 26. P. 1069–1075.

7. Российские рекомендации Российского кардиологического общества. Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза: V пересмотр. – М., 2012.

8. De Fronzo R. A., Ferrannini E. Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease // Diabetes Care. 1991. Vol. 14. P. 173–194.

9. Борисова Е. П. Показатели липидного профиля у лиц якутской национальности с метаболическим синдромом в сочетании с патологией органов дыхания / Е. П. Борисова, Е. С. Кылбанова // Кардиоваскулярная терапия и профилактика. – 2015. – № 3. – С. 39–42.

10. Климова Т. М. Липидный профиль и дислипопротеинемии у коренного сельского населения Якутии / Т. М. Климова [и др.] // Сиб. мед. журн. – Томск. – 2012. – № 3 (27). – С. 142–146.

11. Никитин Ю. П. Нужен ли критерий ХС ЛПНП в дефинициях метаболического синдрома? / Ю. П. Никитин [и др.] // Атеросклероз. – 2014. – № 1. – С. 39–43.

12. Романова А. Н. Метаболический синдром и коронарный атеросклероз у жителей Якутии / А. Н. Романова, М. И. Воевода, А. С. Гольдерова // Бюл. СО РАМН. – 2011. – Т. 31, № 5. – С. 90–99.

13. Алексеева Т. И. Адаптация человека в различных экологических нишах Земли (биологические аспекты) / Т. И. Алексеева. – М.: МНЭПУ, 1998. – 280 с.

14. Николаев И. В. Анализ взаимодействия аллелей генов липидного обмена при дислипидемии / И. В. Николаев [и др.] // Вавиловский журн. генетики и селекции. – 2014. – № 18. – С. 856–866.

15. Асекритова А. С. Гастроэзофагеальная рефлюксная болезнь в сочетании с метаболическим синдромом у жителей Якутии / А. С. Асекритова, Е. С. Кылбанова, Э. А. Емельянова // Якут. мед. журн. – 2015. – № 1. – С. 6–8.

16. Асекритова А. С. Гастроэзофагеальная рефлюксная болезнь у якутов с метаболическим синдромом / А. С. Асекритова, Е. С. Кылбанова, Э. А. Емельянова // Сиб. мед. журн. – Иркутск. – 2014. – № 5. – С. 24–27.

17. Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. / C. Hoyo, M. Cook, F. Kamangar et al. // Int. J. Epidemiol. 2012. N 41 (6). P. 1706–1718.

18. Correlation of gastroesophageal reflux disease symptoms with body mass index / S. Zafar, I. Haque, G. Tayyab et al. // Saudi J. Gastroenterol. 2008. N 14 (2). P. 53–57.

19. Association between obesity and Barrett’s esophagus in a Japanese population: a hospital-based, cross-sectional study / J. Watari, K. Hori, F. Toyoshima et al. // BMC Gastroenterol. 2013. N 13. P. 143.

20. Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis / S. Singh, A. Sharma, M. Murad et al. // Clin. Gastroenterol. Hepatol. 2013. N 11 (22). P. 1399–1427.

21. Prevalence and risk factors of gastroesofageal reflux symptoms in Chinese retiree cohort / T. Chen, M. Lu, X. Wang et al. // BMC Gastroenterology. 2012. N 12 (161). P. 7.