Mechanisms of organization degenerative aortic valve stenosis in elderly patients with arterial hypertension
Abstract
The aim of the present work was to investigate hemodynamic, hormonal, metabolic determinants and their correlations in patients with aortic valve stenosis and nonobstructive aortal calcification. 212 patients elder than 60 years with arterial hypertension were under observation. Were shown that hyperuricemia and hypothyroids to be significantly frequent detected in patients with nonobstructive aortic calcification if compared with patients with aortic valve stenosis. Possible mechanisms of organization degenerative aortic valve stenosis including parathyroid glands hyperfunction and genetic determinants were discussed.
About the Authors
G. N. Vereshchagina
Novosibirsk State Medical University
Russian Federation
Russian Federation
630091
Krasnyi av., 52
Novosibirsk
E. A. Chibisova
Novosibirsk State Medical University
Russian Federation
Russian Federation
630091
Krasnyi av., 52
Novosibirsk
I. M. Mitrofanov
Novosibirsk State Medical University
Russian Federation
Russian Federation
630091
Krasnyi av., 52
Novosibirsk
O. V. Lisichenko
Novosibirsk State Medical University
Russian Federation
Russian Federation
630091
Krasnyi av., 52
Novosibirsk
References
1. O’Brien K. D. Epidemiology and genetics of calcific aortic valve disease // J. Investig. Med. 2007. Vol. 55. P. 284–291.
2. Messika-Zeitoun D., Bielak L. F., Peyser P. A. et al. Aortic valve calcification: determinants and progression on the population // Arterioscler. Tromb. Vasc. Biol. 2007. Vol. 27, N 3. P. 642–648.
3. Otto C. M. Calcific aortic stenosis – time to look more closely at valve // New Engl. J. Med. 2008. Vol. 359. P. 1395–1398.
4. Tenenbaum A. et al. Aortic valve calcification in hypertension patient: risk factors and association with transvascular flow velocity // Int. J. Cardiol. 2004. Vol. 94, N 1. P. 7–13.
5. Fleg J. L. Alterations in cardiovascular structure and function with advancing age // Amer. J. Cardiol. 1986. Vol. 57. P. 33.
6. Дземешкевич С. Л..Болезни аортального клапана. Функция-диагностика-лечение / С. Л. Дземешкевич [и др.] – ГЭОТАР-мед. – М., 2004. – Гл. 2. – С. 45–75.
7. Katzeff H. L. et al. // Amer. J. Physiol. 1997. Vol. 273. P. E951–E956.
8. Mohler E. R., Chawla M. K., Chang A. W. et al. Identification and characterization of calcifying valve cells from human and canine aortic valves // J. Heart Valve Dis. 1999. Vol. 8, N 3. P. 254.
Review
For citations:
Vereshchagina G.N., Chibisova E.A., Mitrofanov I.M., Lisichenko O.V. Mechanisms of organization degenerative aortic valve stenosis in elderly patients with arterial hypertension. Ateroscleroz. 2015;11(2):20-23. (In Russ.)
Views:
178
Email this article 