Association of central aortic pressure with components of metabolic syndrome
Abstract
Goal. Central aortic pressure (CAP) is regarded as a perspective indicator of the cardiovascular risk. It is interesting to study the association between the CAP and the components of the metabolic syndrome.
Research methods. We studied 69 individuals (46 women and 23 men) aged 56–78 years: 34 – research participants of the population sampling of Novosibirsk and 35 – outpatients. The components of the metabolic syndrome was determined according to the criteria of RSC 2009. Central aortic pressure was determined on a Sphygmo Cor (At Cor Medical, Australia). Omron HEM9000AI device (Omron, Japan) was used to calibrate the instrument. Data was analyzed in the GLM. Results are presented as mean value with a measure of the variation as an average error.
Results. Multivariate analysis with the simultaneous inclusion in the model age, sex, abdominal obesity, hypertriglyceridemia, hypo-alpha-cholesterolemia, hyper-beta-cholesterolemia, fasting hyperglycemia have revealed that only hypertriglyceridemia was a significant independent determinant of systolic and diastolic CAP (p = 0,014 and p = 0,008, respectively) from all of analyzed components.
Findings. The results of the study indicate that the central aortic pressure, regardless of age and sex was associated with only one component of the metabolic syndrome – hypertriglyceridemia.
About the Authors
E. E. Tsvetkova
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
A. A. Kuznetsov
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
A. V. Sukhanov
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
Yu. I. Ragino
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
M. V. Ivanova
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
S. N. Duma
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
V. V. Gafarov
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
M. I. Voevoda
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
References
1. Roman M. J., Devereux R. B., Kizer J. R. et al. Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study // Hypertension. 2007. Vol. 50. P. 197–203.
2. Vlachopoulos C., Aznaouridis K., O’Rourke M. F. et al. Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis // Eur. Heart J. 2010. Vol. 3. P. 1865–1871.
3. Wang K. L., Cheng H. M., Chuang S. Y., Spurgeon H. A., Ting C. T., Lakatta E. G. et al. Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality? // J. Hypertens. 2009. Vol. 27. P. 461–467.
4. Williams B., O’Rourke M. The Conduit Artery Functional Endpoint (CAFE) study in ASCOT // J. Hum. Hypertens. 2001. Vol. 15 (suppl 1). P. S69 –S73.
5. The CAFE Investigators, CAFE Steering Committee and Writing Committee, Bryan Williams, Peter S. Lacy, Simon M. Thom, Kennedy Cruickshank, Alice Stanton, David Collier, Alun D. Hughes, H. Thurston and Michael O’Rourke. Differential Impact of Blood Pressure−Lowering Drugs on Central Aortic Pressure and Clinical Outcomes: Principal Results of the Conduit Artery Function Evaluation (CAFE) Study // Circulation. 2006. Vol. 113. P. 1213–1225.
6. Dahlof B., Sever P. S., Poulter N. R., Wedel H., Beevers D. G., Caulfield M., Collins R., Kjeldsen S. E., Kristinsson A., McInnes G. T., Mehlsen J., Nieminen M., O’Brien E., Ostergren J. For the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial–Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial // Lancet. 2005. Vol. 366. P. 895–906.
7. Poulter N. R., Wedel H., Dahlof B., Sever P. S., Beevers D. G., Caulfield M., Kjeldsen S. E., Kristinsson A., McInnes G. T., Mehlsen J., Nieminen M., O’Brien E., Ostergren J., Pocock S. For the ASCOT Investigators. Role of blood pressure and other variables in the dif-ferential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial–Blood Pressure Lowering Arm (ASCOT-BPLA) // Ibid. P. 907–914.
8. Гусаковская Л. И. Амбулаторное мониторирование аортального давления и сосудистой ригидности у больных гипертонией 1–2 степени с оценкой вазопротективного действия антигипертензивной терапии: автореф. дис.… канд. мед. наук. – Пенза, 2012.
9. Konstantinos Aznaouridis, Charalambos Vlachopoulos, Ioanna Dima, Nikolaos Ioakeimidis, Christodoulos Stefanadis. Triglyceride level is associated with wave reflections and arterial stiffness in apparently healthy middle-aged men // Heart. 2007. Vol. 93. P. 613–614.
10. Кузнецов А. А. Ассоциация артериальной жесткости с компонентами метаболического синдрома / А. А. Кузнецов [и др.] // Атеросклероз. – 2013. – Т. 9, № 2. – С. 29–32.
Review
For citations:
Tsvetkova E.E., Kuznetsov A.A., Sukhanov A.V., Ragino Yu.I., Ivanova M.V., Duma S.N., Gafarov V.V., Voevoda M.I. Association of central aortic pressure with components of metabolic syndrome. Ateroscleroz. 2014;10(4):37-40. (In Russ.)
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