Some common candidate genes in arterial hypertension and gallstlone disease pathogenesis
Abstract
Gallstone disease (GSD) and arterial hypertension (AH) have many common risk factors – age, overweight, dyslipidemia, low physical activity, diabetes mellitus, in addition, the presence of AH is considered by many authors as a risk factor for GSD. Numerous trials are devoted to the study of the contribution of gene polymorphisms in the development of AH, but researches about common candidate genes for AH and GSD are rare. In several studies, including a meta-analysis, the association of GSD and APOE4 allele genotype is depicted. Our clinical study in women with GSD in combination with AH shows the greatest frequency of allele APOE4 (21.2) compared with women with GSD without AH (8.0) or with women with isolated AH (10.6, p < 0.05). Also in this study, we found no significant differences in the frequency of genotypes A/A, A/G and G/G polymorphism A145G ADRB1 gene in women with AH in combination with GSD and women with isolated AH. Earlier in epidemiological study we did not found any association of GSD with I/D polymorphism of angiotensin converting enzyme gene. Thus, further research is needed to find a common candidate genes involved in the regulation of blood pressure and in the development of GSD in each population that will help identify patients at highest risk of complications of GSD and AH.
About the Authors
M. S. Lebedeva
RAMS; «Russian Railways» Open Joint Stock Company
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Railway Clinical Hospital on the Station Novosibirsk-Glavnyi
630003
Vladimirovskiy spusk, 2a
Novosibirsk
I. N. Grigorieva
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
N. P. Tatarnikova
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
V. N. Maksimov
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
References
1. Ильченко А. А. Желчно-каменная болезнь / А. А. Ильченко. – М.: Анахарсис, 2004. – 2000 с.
2. Григорьева И. Н. Основные факторы риска желчно-каменной болезни / И. Н. Григорьева // РЖГГК. – 2007. – № 6. – C. 17–21.
3. Григорьева И. Н. Липидный профиль при желчно-каменной болезни: новые перспективы / И. Н. Григорьева, Л. В. Щербакова // Атеросклероз. – 2011. – № 1. – C. 70–75.
4. Григорьева И. Н. Частота сочетания желчно-каменной болезни и сахарного диабета / И. Н. Григорьева, А. Ю. Ямлиханова // Экспер. и клин. гастроэнтерология. – 2011. – № 4. – С. 99–102.
5. Mendez-Sanchez N., Bahena-Aponte J., Chavez-Tapia N. Strong association between gallstones are cardiovascular disease // Am. J. Gastroenterol. 2005. Vol. 100. P. 827–830.
6. Максимов В. А. Современная терапия заболеваний органов пищеварения / В. А. Максимов [и др.] – М.: Изд-во «АдамантЪ», – 2011. – 712 с.
7. Cariati A., Piromali E. Limits and perspective of oral therapy with statins and aspirin for the prevention of symptomatic cholesterol gallstone disease // Expert Opin Pharmacother. 2012. Vol. 13, N 9. P. 1223–1227.
8. Петухов В. А. Желчно-каменная болезнь и беременность: причинно-следственные взаимосвязи / В. А. Петухов, М. Р. Кузнецов, С. В. Лисин // Анн. хирургии. – 1998. – № 2. C. 14–21.
9. Григорьева И. Н. Урсодезоксихолевая кислота во внутренней медицине / И. Н. Григорьева. – М.: Медпрактика-М, 2012. – 158 с.
10. Yoo E.-H., Lee S.-Y. The prevalence and risk factors for gallstone disease // Clin. Chem. Lab. Med. 2009. Vol. 47, N 7. P. 795–807.
11. Lammert F., Sauerbruch T. Mechanisms of disease: the genetic epidemiology of gallbladder stones // Nat. Clin. Pract. Gastroenterol. Hepatol. 2005. Vol. 2. P. 423–433.
12. Wang D. Q., Cohen D. E., Carey M. C. Biliary lipids and cholesterol gallstone disease // J. Lipid Res. 2009. Vol. 50. P. 406–411.
13. Moschetta A., van Berge-Henegouwen G. P., Portincasa P., Palasciano G., van Erpecum K. J. Cholesterol crystallization in model biles: effects of bile salt and phospholipid species composition // J. Lipid Res. 2001. Vol. 42, N 8. P. 1273–1281.
14. Xu Q., Tao L. Y., Wu Q., Gao F., Zhang F. L., Yuan L., He. X. D. Prevalences of and risk factors for biliary stones and gallbladder polyps in a large Chinese population // HPB (Oxford). 2012. Vol. 14, N 6. P. 373–381.
15. Chen C. Y., Lu C. L., Lee P. C. The risk factors for gallstone disease among senior citizens: an Oriental study // Hepatogastroenterology. 1999. Vol. 46, N 27. P. 1607–1612.
16. Григорьева И. Н. Артериальная гипертензия и ишемическая болезнь сердца как факторы риска ЖКБ у женщин / И. Н. Григорьева [и др.] // Гастро-бюллетень. – 2000. – № 1-2. – С. 49–50.
17. Chavez-Tapia N. C., Kinney-Novelo I. M., Sifuentes-Renteria S. E. Association between cholecystеctomy for gallstone disease and risk factors for cardiovascular disease // Ann. Hepatology. 2012. Vol. 11, N 1. P. 85–89.
18. Mendez-Sanchez N., zamora-Valdes D., Flores-Rangel J. A. et al. Gallstones are associated with carotid atherosclerosis // Liv. Int. 2008. Vol. 28. P. 402–406.
19. Nilsson E., Fored C. M., Granath F. Cholecystectomy in Sweden 1987-99: a nationwide study of mortality and preoperative admissions // Scand. J. Gastroenterol. 2005. Vol. 40, N 12. P. 1478–1485.
20. Максимов В. Н. Связь наследственной отягощенности и полиморфизма некоторых генов-кандидатов с сердечно-сосудистыми заболеваниями и их факторами риска в городской популяции Западной Сибири: автореф. дис. … д-ра мед. наук / В. Н. Максимов. – Новосибирск, 2007. – 45 с.
21. Григорьева И. Н. Роль гиперлипидемии при желчнокаменной болезни / И. Н. Григорьева, С. К. Малютина, М. И. Воевода // Эксп. и клин. гастроэнтерология. – 2010. – Т. 4. – C. 64–68.
22. Sotos-Prieto M. L., Peсalvo J. L. Genetic variation of apolipoproteins, diet and other environmental interactions; an updated review // Nutr. Hosp. 2013. Vol. 28. P. 999–1009.
23. Berkinbayev S., Rysuly M., Mussayev A. Apolipoprotein Gene Polymorphisms (APOB, APOC111, APOE) in the Development of Coronary Heart Disease in Ethnic Groups of Kazakhstan // J. Genet. Syndr. Gene Ther. 2014. Vol. 24, N 5 (2). P. 216.
24. Kesaniemi Y. A., Ehnholm C., Miettinen T. A. Intestinal cholesterol absorbtion efficiency is related to apolipoprotein E phenotype // J. Clin. Invest. 1987. Vol. 80. P. 578–581.
25. Sama C., LaRusso N. F. Effect of deoxycholic, chenodeoxycholic and cholic acids on intestinal absorbtion of cholesterol in humans // Mayo Clin. Proc. 1982. Vol. 57. P. 44–50.
26. Miettinen T. A. Impact of Apo E phenotype on the regulation of cholesterol metabolism // Ann. Med. 1991. Vol. 23. P. 181–186.
27. Weintraub M., Eisenberg S., Breslow J. Dietary fat clearance in normal subjects is regu-lated by genetic variation in apolipoprotein E // J. Clin. Invest. 1987. Vol. 80. P. 1571–1577.
28. Angelin B., Holmquist L., Leijd B. Bile acid metabolism in familial disbetalipoproteinaemia: studies in subjects with the apolipoprotein E 2/2 phenotype // Eur. J. Clin. Invest. 1990. Vol. 20. P. 143–149.
29. Kervinen K., Savolainen M. J., Salokannel J., Hynninen A., Heikkinen J. Apolipoprotein E and B polymorphisms–longevity factors assessed in nonagenarians // Atherosclerosis. 1994. Vol. 105. P. 89–95.
30. Bertomeu A., Ros E., zambon D. Apolipoprotein E polymorphism and gallstones // Gastroenterology. 1996. Vol. 111. P. 1603–1610.
31. Fischer S., Dolu M. H., zündt B. Apolipoprotein E polymorphism and lithogenic factors in gallbladder bile // Eur. J. Clin. Invest. 2001. Vol. 31, N 9. P. 789–795.
32. Niemi M., Kervinen K., Rantala A. The role of apolipoprotein E and glucose intolerance in gallstone disease in middle aged subjects // Gut. 1999. Vol. 44, N 4. P. 557–562.
33. Van Erpecum K. J., Portincasa P., Dohlu M. H. Biliary pronucleating proteins and apolipoprotein E in cholesterol and pigmentstone patients // J. Hepatology. 2003. Vol. 39, N 1. P. 7–11.
34. Григорьева И. Н. Генетические аспекты заболеваний органов пищеварения. – Часть I / И. Н. Григорьев [и др.] // Терапевт. арх. – 2010. – № 2. – C. 62–66.
35. Boland L. L., Folsom A. R., Boerwinkle E. Atherosclerosis Risk in Communities (ARIC) Study Investigators Apolipoprotein E genotype and gallbladder disease risk in a large population-based cohort // Ann. Epidemiol. 2006. Vol. 16, N 10. P. 763–769.
36. Lin Q. Y., Du J. P., Zhang M. Y. Effect of apolipoprotein E gene Hha I restricting fragment length polymorphism on serum lipids in cholecystolithiasis // World J. Gastroenterol. 1999. Vol. 5, N 3. P. 228–230.
37. Cynthia C. W. Ko., Beresford S. A. A., Alderman B. Apolipoprotein E genotype and the risk of gallbladder disease in pregnancy // Hepatology. 2000. Vol. 31, N 1. P. 18–23.
38. Dixit M., Choudhuri G., Mittal B. Association of APOE-C1 gene cluster polymorphisms with gallstone disease // Dig. Liver Disease. 2006. Vol. 38. N 6. P. 397–403.
39. Hasegawa K., Terada S., Kubota K. Effect of apolipoprotein E polymorphism on bile lipid composition and the formation of cholesterol gallstone // Am. J. Gastroenterol. 2003. Vol. 98, N 7. P. 1605–1609.
40. Jiang Z. Y., Han T. Q., Suo G. J. Polymorphisms at cholesterol 7α-hydroxylase, apolipoproteins B and E and low density lipoprotein receptor genes in patients with gallbladder stone disease // World J. Gastroenterol. 2004. Vol. 10, N 10. P. 1508–1512.
41. Mella J. G., Schirin-Sokhan R., Rigotti A., Pimentel F., Villarroel L., Wasmuth H. E., Sauerbruch T., Nervi F., Lammert F., Miquel J. F. Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations // J. Lipid Res. 2007. Vol. 48, N 6. P. 1378–1385.
42. Sanchez-Cuen J., Aguilar-Medina M., Arámbula-Meraz E., Romero-Navarro J., Granados J., Sicairos-Medina L., Ramos-Payán R. ApoB-100, ApoE and CYP7A1 gene polymorphisms in Mexican patients with cholesterol gallstone disease // World J. Gastroenterol. 2010. Vol. 16, N 37. P. 4685–4690.
43. Sarin S. K., Negi V. S., Dewan R. High familial prevalence of gallstones in the first-degree relatives of gallstone patients // Hepatology. 1995. Vol. 22, N 1. P. 138–141.
44. Portincasa P., van Erpecum K. J., van de Meeberg P. C. Apolipoprotein E genotype and gallbladder motility influence speed of gallstone clearance and risk of recurrence after extracorporeal shock-wave lithotripsy // Hepatology. 1996. Vol. 24. P. 580–587.
45. Venneman N. G., van Berge-Henegouwen G. P., Portincasa P., Stolk M. F., Vos A., Plaisier P. W., van Erpecum K. J. Absence of apolipoprotein E4 genotype, good gallbladder motility and presence of solitary sto-nes delay rather than prevent gallstone recurrence after extracorporeal shock wave lithotripsy // J. Hepatol. 2001. Vol. 35. P. 10–16.
46. Van Erpecum K. J., Portincasa P., Eckhardt E. R. M. Increased risk of cholesterol gallstone formation in subjects with apolipoprotein E4 genotype: its relation to bile composition and crystallization // Gastroenterology. 1998. Vol. 114, N 4. P. A547.
47. Juvonen T., Kervinen K., Kairaluoma M. I., Lajunen L. H., Kesäniemi Y. A. Gallstone cholesterol content is related to apolipoprotein E polymorphism // Gastroenterology. 1993. Vol. 104, N 6. P. 1806–1813.
48. Van Erpecum K. J., van Berge-henegouwen G. P., Eckhardt E. R., Portincasa P., van De Heijning B. J., Dallinga-Thie G. M., Groen A. K. Cholesterol crystallization in human gallbladder bile: relation to gallstone number, bile composition, and apolipoprotein E4 isoform // Hepatology. 1998. Vol. 27, N 6. P. 1508–1516.
49. Xue P., Niu W. Q., Jiang Z. Y., Zheng M. H., Fei J. A meta-analysis of apolipoprotein E gene ε2/ε3/ε4 polymorphism for gallbladder stone disease // PLoS One. 2012. Vol. 7, N 9. P. e45849.
50. Kato I., Land S., Barnholtz-Sloan J., Severson R. K. APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease // Cholesterol. 2011. Vol. 2011. P. 896360.
51. Song Y., Stampfer M. J., Liu S. Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease // Ann. Intern. Med. 2004. Vol. 141, N 2. P. 137–147.
52. Bennet A. M., Di A. E., Ye Z. Association of apolipoprotein E genotypes with lipid levels and coronary risk // J. Am. Med. Association. 2007. Vol. 298, N 11. P. 1300–1311.
53. Li X., Du Y., Du Y. Association of apolipoprotein E gene polymorphism with essential hypertension and its complications // Clin. Exp. Med. 2003. Vol. 2, N 4. P. 175–179.
54. Yilmaz H., Isbir T., Ağaçhan B., Aydin M. Is epsilon4 allele of apolipoprotein E associated with more severe end-organ damage in essential hypertension? // Cell Biochem. Funct. 2001. Vol. 19, N 3. P. 191–195.
55. Григорьева И. Н. Генетические аспекты заболеваний органов пищеварения. – Ч. I / И. Н. Григорьева [и др.] // Терапевт. арх. – 2010.– № 2.– C. 62–66.
56. Григорьева И. Н. Полиморфизм генов АРОЕ, IL-1β и TNF-α и клинические особенности течения желчнокаменной болезни у женщин в сочетании с метаболическим синдромом / И. Н. Григорьева [и др.] // Вестн. НГУ. – 2013. – Т. 11, № 2. – C. 59–65.
57. Григорьева И. Н. Полиморфизм гена аполипопротеина Е, желчнокаменная болезнь и панкреатит / И. Н. Григорьева [и др.] // Бюл. СО РАМН. – 2006. – № 3. – C. 80–87.
58. Григорьева И. Н. Полиморфизм гена APOE и литогенность желчи у женщин с желчнокаменной болезнью / И. Н. Григорьева [и др.] // Эксперим. клин. гастроэнтерология. – 2009. – № 8. – C. 56–60.
59. Abu Abeid S., Szold A., Gavert N., Goldiner I., Grynberg E., Peretz H., Konikoff F. mM. Apolipoprotein-E genotype and the risk of developing cholelithiasis following bariatric surgery: a clue to prevention of routine prophylactic cholecystectomy // Obes Surg. 2002. Vol. 12, N 3. P. 354–357.
60. Porchay-Baldérelli I., Péan F., Emery N. DIABHYCAR Study Group. Relationships between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and high-density lipoprotein cholesterol and coronary heart disease in a population with type 2 diabetes mellitus // Metabolism. 2009. Vol. 58, N 1. P. 74–79.
61. Doosti M., Najafi M., Reza J. Z., Nikzamir A. The role of ATP-binding-cassette-transporter-A1 (ABCA1) gene polymorphism on coronary artery disease risk // Transl Res. 2010. Vol. 155, N 4. P. 185–190.
62. Xia X., Jung D., Webb P. Liver X receptor в and peroxisome proliferator-activated receptor д regulate cholesterol transport in murine cholangiocytes // Hepatology. 2012. Vol. 56, N 6. P. 2288–2296.
63. Baier L. J., Bogardus C., Sacchettini J. C. A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells // J. Biol. Chem. 1996. Vol. 271, N 18. P. 10892–10896.
64. Georgopoulos A., Aras O., Tsai M. Y. Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes // J. Clin. Endocrinol. Metab. 2000. Vol. 85, N 9. P. 3155–3160.
65. Vidgren H. M., Sipiläinen R. H., Heikkinen S., Laakso M., Uusitupa M. I. J. Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects // Eur. J. Clin. Invest. 1997. Vol. 27, N 5. P. 405–408.
66. Agren J. J., Vidgren H. M., Valve R. S., Laakso M., Uusitupa M. I. Postprandial responses of individual fatty acids in subjects homozygous for the threonineor alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene // Am. J. Clin. Nutr. 2001. Vol. 73, N 1. P. 31–35.
67. Yamada K., Yuan X., Ishiyama S. Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men // Diabetologia. 1997. Vol. 40, N 6. P. 706–710.
68. Bagmet A. D., Shestopal N. S. [I/D-polymorphism of ACE gene, morphofunctional heart condition and blood pressure 24-h profile in young men with arterial hypertension] // Ter. Arkh. 2005. Vol. 77, N 9. P. 16–20.
69. Chandra S., Narang R., Saluja D., Bhatia J., Srivastava K. Expression of angiotensin-converting enzyme gene in whole blood in patients with essential hypertension // Biomarkers. 2014. Vol. 9. [Epub ahead of print].
70. Celentano A., Mancini F. P., Crivaro M., Palmieri V. [Absence of an association of the D allele of the ACE gene with arterial pressure in mild-moderate essential arterial hypertension] // Cardiologia. 1996. Vol. 41, N 10. P. 995–1000.
71. Григорьева И. Н. Желчно-каменная болезнь, ассоциирована с артериальной гипертензией, но не с полиморфизмом гена ангиотензин-превращающего фермента (эпидемиологическое исследование) / И. Н. Григорьева [и др.] // РЖГГК. – 2008. – Т. 5 (Прил. 32). – С. 584.
72. Iwamoto Y., Ohishi M., Yuan M., Tatara Y., Kato N., Takeya Y., Onishi M., Maekawa Y., Kamide K., Rakugi H. β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients // Hypertens Res. 2011. Vol. 34, N 5. P. 573–577.
73. Kannel W. B., Kannel C., Paffenbarger R. S. Jr., Cupples L. A. Heart rate and cardiovascular mortality: the Framingham Study // Am. Heart J. 1987. Vol. 113, N 6. P. 1489–1494.
74. Леванов А. Н. Связь генетического полиморфизма бета-адренорецепторов с эффективностью терапии бета-адреноблокаторами у больных с сердечно-сосудистой патологией / А. Н. Леванов [и др.] // Саратов. науч.-мед. журн. – 2009. – Т. 5, № 1. – С. 41–44.
75. Muszkat M. Pharmacogenetics and response to beta-adrenergic receptor antagonists in heart failure Clin. Pharmacol // Ther. 2005. Vol. 77, N 3. Р. 123–126.
76. Larisa M. Humma, Brian J. Puckett. Effects of beta1-adrenoreceptor genetic polymorphisms on resting hemodynamics in patients undergoing diagnostic testing for ischemia // Am. J. Cardiol. 2001. Vol. 88. P. 110.
77. Linne Y., Dahlman I., Hoffstedt J. Beta1-Adrenoceptor gene polymorphism predicts long-term changes in body weight // Int. J. Obes. Relat. Metab. Disord. 2005. Vol. 29, N 5. P. 458–462.
78. Estrada-Velasco B. I., Cruz M., Madrid-Marina V. IRS1, TCF7L2, ADRB1, PPARG, and HHEX polymorphisms associated with atherogenic risk in Mexican population // Biomed. Res. Int. 2013. Vol. 2013. P. 394523.
79. Link Richard E., Kavin Desai, Lutz Hein. Cardiovascular Regulation in Mice Lacking 2-Adrenergic Receptor Subtypes b and c // Science. 1996. Vol. 273, Issue 5276. P. 803–805.
80. Snapir A., Mikkelsson J., Perola M., Penttila A., Scheinin M., Karhunen P. J. Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death // J. Am. Coll. Cardiol. 2003. Vol. 15, N 41 (2). P. 190–194.
81. Zhang H., Li X., Huang J. Cardiovascular and metabolic phenotypes in relation to the ADRA2B insertion / deletion polymorphism in a Chinese population // J. Hypertens. 2005. Vol. 23, N 12. P. 2201–2207.
82. Cho J. Y., Han H. S., Yoon Y. S., Ahn K. S. Risk factors for acute cholecystitis and a complicated clinical course in patients with symptomatic cholelithiasis // Arch. Surg. 2010. Vol. 145, N 4. P. 329–333.
83. Molinari C., Grossini E., Mary D. A., Vacca G. Effect of distension of the gallbladder on plasma renin activity in anesthetized pigs // Circulation. 2000. Vol. 101, N 21. P. 2539–2545.
Review
For citations:
Lebedeva M.S., Grigorieva I.N., Tatarnikova N.P., Maksimov V.N. Some common candidate genes in arterial hypertension and gallstlone disease pathogenesis. Ateroscleroz. 2014;10(2):43-50. (In Russ.)
Views:
206
Email this article 