Hyperuricemia and degenerative pathology of aortic valve in elderly patients
Abstract
The purpose was to investigate a frequency of hyperuricemia and its relations with risk factors of degenerative pathology at patients who are elder than 60 years.
Methods and result. We examined 212 patients with arterial hypertension and degenerative pathology of aortic valve, of which 76 with nonobstructive aortal calcification and 136 patients with aortic valve stenosis. In blood glucose level, lipids, uric acid, TTH and free T4 were defined.
Results: A frequency of hyperuricemia was 30.7 %, overt hypothyroidism 11,3 %, high normal TTH level 11.8 %. In women a combination of hyperuricemia and overt hypothyroidism was 39.3 %, in men it was 8.1 %. A negative correlation was found between glucose level and hyperuricemia.
About the Authors
G. N. Vereshchagina
Russian Ministry of Health
Russian Federation
Russian Federation
State Budgetary Educational Institution of Higher Professional Education "Novosibirsk State Medical University"
630091
Red Avenue, 52
Novosibirsk
Е. А. Chibisova
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal state budgetary institution "Scientific Center for Clinical and Experimental Medicine"
630117
st. Timakova, 2
Novosibirsk
I. М. Mitrofanov
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal state budgetary institution "Scientific Center for Clinical and Experimental Medicine"
630117
st. Timakova, 2
Novosibirsk
А. V. Shabalin
РАМН
Russian Federation
Russian Federation
References
1. Goodman W. G., London G., Amann K. et al. Vascular calcification in chronic kidney disease //Am. J. Kidney Disease. 2004. Vol. 43. Р. 572–579.
2. Stewart B. F., Siscovick D., Lind B. K. et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular health study // J. Amer. Coll. Cardiol. 1997. Vol. 29, N 3. Р. 630–634.
3. Faggiano P., Antonini-Canterin F., Baldessin F. et al. Epidemiology and cardiovascular risk factors of aortic stenosis // Cardiovasc. Ultrasound. 2006. Vol. 4, N 27. Р. 1186–1476.
4. Khosta U. M., Zharikov S., Finch J. et al. Hyperuricemia induces endothelial disfunction // Kidney Int. 2005. Vol. 67, N 5. P. 1739–1742.
5. Chao H. H., Liu S. C., Lin J. W. et al. Uric acid stimulates endothelin-1 gene expression associated with NAD PH oxidase in human aortic smooth muscle cells // Act. Pharmacol. Sin. 2008. Vol. 29, N 2. P. 1301–1312.
6. Лебедева М. В. Альбуминурия, плазменная концентрация эндотелина-1 и атеросклеротическое поражение сонных артерий у больных артериальной гипертензией и гиперурикемией / М. В. Лебедева, Т. Ю. Стахова, И. М. Балкаров // Клин. нефрология. – 2009. – Т. 3. – С. 57–61.
7. Bagnati M., Perugini C., Cau C. When and why a water soluble antioxidant becomes prooxidant during copperinduced
8. lowdensity lipoprotein oxidation: a study using uric acid // Biochem. J. 1999. Vol. 340. P. 1431—1452.
9. ACC / AHA guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology American Heart Association Task Force of Practice Guidelines (Committee of Management of Patients with Valvular Heart Disease) // J. Am. Coll. Cardiol. 1998. Vol. 32. P. 1486–
10.
11. Tenenbaum A. Aortic valve calcification in hypertension patient: risk factors and association with transval-vular flow velocity // Int. J. Cardiol. 2004. Vol. 94, N 1. P. 7–13.
12. Zhang W. EULAR evidence based recommendations for gout. Part I : Diagnosis. Report of a task force of the standing committee for international clinical studies including therapeutics (ESCISIT) // Ann. Rheum. Dis. 2006. Vol. 65. P. 1301–1311.
13. Alderman M. H. Serum uric acid as a cardiovascular risk factor for heart disease // Curr. Hypertens. Res. 2001. Vol. 3, N. 3. P. 184–189.
14. Lekakis J., Papamichael C., Alevizaki M. et al. Flowmediated, endothelium-dependent vasodilatation is impaired in subject with hypothyroidism, borderline hypothyroidism, and higt-normal serum thyrotropin (TSH) values // Thyroid. 1997. Vol. 7. P. 411–414.
15. Hollowell J. G., Staehling N. W., Flanders W. D., Hannon W. H., Gunter E. W., Spencer C. A., Braverman L. E. Serum TSH, T (4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III) // J. Clin Endocrinol. Metab. 2002. Vol. 87. P. 489–499.
16. Baloch Z., Carayon P., Conte-Devolx B., Demers L. M.,
17. Feldt Rasmussen U., Henry J. F., Li Vosli V. A., Niccoli-Sire P., John R., Smyth P. P., Spencer C. A. Gui delines Committee, National Academy of Clinical Biochemistry. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease// Thyroid. 2003. Vol. 13. P. 3–126.
18. Goya Wannamethee S.: Serum Uric Acid Is Not an Independent Risk Factor for Coronary Heart Disease // Curr. Hypertens. Res. 2001. Vol. 3. Р. 190–196.
19. Ioachimescu A., Brennan D., Hoar B. et al. Serum Uric Acid Is an Independent predictor of all-cause mortality in patient at high risk of cardiovascular disease: a preventive cardiology information system database cohort study // Arthritis Rheum. 2008. Vol. 58. Р. 623–630.
20. Corry D., Eslami P., Yamamoto K. Uric Acid stimulated vascular smooth muscle cell proliferation and oxidative stress via the vascular rennin-angiotensin system // J. Hypertens. 2008. Vol. 26. Р. 269–285.
21. Karjalainen P., Saarland H., Laakso M. Long term association of cardiovascular risk factors with impaired insulin secretion and insulin resistance // Metabolism. 2000. Vol. 49. P. 1247–1254.
Review
For citations:
Vereshchagina G.N., Chibisova Е.А., Mitrofanov I.М., Shabalin А.V. Hyperuricemia and degenerative pathology of aortic valve in elderly patients. Ateroscleroz. 2013;9(3-4):38-43. (In Russ.)
Views:
174
Email this article 