Hormones of stress and coronary syndrome X (experimental research)
Abstract
Experiments studies which showed are carried out that stress hormones (a cortisol, adrenaline) can bind to erythrocyte membranes with high affinity, leading to rough structural changes. The last are accompanied by increase of microviscosity of membranes as in area a lipid-lipid, and protein-lipid of interactions. The nature of these changes is caused by simultaneous interaction of active groups of hormones (NH, OH and their waterproof rings) at the same time with a lipid and protein components of a membrane with formation of domains. Experiments with heart perfusion of rats showed that erythrocytes with the increased microviscosity of their membranes are incapable to move ahead on the capillary course that leads to sharp decrease in a coronary stream and fast cardiac arrest. The assumption is come out that this mechanism is shown and at a coronary syndrome X at the person.
About the Authors
L. E. Panin
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal state budgetary institution "Research Institute of Biochemistry"
630117
st. Timakova, 2
Novosibirsk
P. V. Mokrushnikov
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal state budgetary institution "Research Institute of Biochemistry"
630117
st. Timakova, 2
Novosibirsk
R. A. Knjazev
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal state budgetary institution "Research Institute of Biochemistry"
630117
st. Timakova, 2
Novosibirsk
A. R. Kolpakov
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal state budgetary institution "Research Institute of Biochemistry"
630117
st. Timakova, 2
Novosibirsk
B. N. Zajitsev
Rospotrebnadzor
Russian Federation
Russian Federation
Federal Budgetary Institution of Science State Scientific Center for Virology and Biotechnology "Vector"
630559
industrial settlement Koltsovo
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Review
For citations:
Panin L.E., Mokrushnikov P.V., Knjazev R.A., Kolpakov A.R., Zajitsev B.N. Hormones of stress and coronary syndrome X (experimental research). Ateroscleroz. 2012;8(2):5-13. (In Russ.)
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