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Interconnection at the level of uric acid and apolipoprotein e in the blood of persons with normal and hyper lipidemia

Abstract

   To investigate the levels of uric acid and apoE in patients with normo- and hyperlipidemia. The serum lipids, apolipoproteins and uric acid levels were measured with Chronolab (Switzerland) kits in 78 patients: 53 patients with normolipidemia and 25 patients with hyperlipidemia of type IIa and IIb. Significantly higher levels of apo-E were registered in patients with hyperlipidemia than in patients with normolipidemia, but there were no differences in content of uric acid. A comparative correlation analysis detected a significant correlation between uric acid and apoE levels in both groups but in normolipidemic patients the correlation was positive while in hyperlipidemic patients it was negative. Hyperlipidemia provokes inversion of correlation between the levels of uric acid, apoE and apoC3. A rise of apoC3 may serve an adaptive mechanism of inhibition of apo-E induced hyperlipidemia.

About the Authors

E. R. Boijko
RAS
Russian Federation

UrO RAS

Establishment of the Russian Academy of Sciences Institute of Physiology of the Komi Scientific Center

167982

Pervomaiskaya str., 50

Syktyvkar



A. O. Ovechkin
RAS
Russian Federation

UrO RAS

Establishment of the Russian Academy of Sciences Institute of Physiology of the Komi Scientific Center

167982

Pervomaiskaya str., 50

Syktyvkar



A. M. Kaneva
RAS
Russian Federation

UrO RAS

Establishment of the Russian Academy of Sciences Institute of Physiology of the Komi Scientific Center

167982

Pervomaiskaya str., 50

Syktyvkar



N. N. Potolitsyna
RAS
Russian Federation

UrO RAS

Establishment of the Russian Academy of Sciences Institute of Physiology of the Komi Scientific Center

167982

Pervomaiskaya str., 50

Syktyvkar



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Review

For citations:


Boijko E.R., Ovechkin A.O., Kaneva A.M., Potolitsyna N.N. Interconnection at the level of uric acid and apolipoprotein e in the blood of persons with normal and hyper lipidemia. Ateroscleroz. 2011;7(1):26-30. (In Russ.)

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