Lipoprotein(a) and atherosclerosis
Abstract
Lp(a) lipoprotein is one of atherogenic forms of lipoproteins, it was discovered over 45 years ago. Lp(a) is a quantitative feature, its concentration being under polygenic control. The Lp(a) concentration level is significantly associated with the risk of CHD development and lipid methabolic disorders. The risk of CHD development was 8–9 % with Lp(a) concentration of 5–10 mg/dl, 18–25 % with the concentration of 14–18 mg/dl and 25–31 % with that of 21–28 mg/dl. Lp(a) plasma concentration level in the population of Siberia varies from 0 to 80 mg/dl. The Lp(a) concentration level from 5 to 18 mg/dl is to be considered the conventional standard and the level of 20 mg/dl and higher – the border of CHD risk development. The level of total cholesterol and LDL cholesterol in all the populations surveyed is associated with Lp(a) plasma concentration level: with 30 mg/dl it is significantly higher as compared with the concentration of 14 mg/dl, and with “zero” concentration it is significantly lower.
About the Author
A. V. Tikhonov
RAMS
Russian Federation
Russian Federation
SB RAMS
Institute of Internal Medicine
Novosibirsk
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Review
For citations:
Tikhonov A.V. Lipoprotein(a) and atherosclerosis. Ateroscleroz. 2007;3(1):3-23. (In Russ.)
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