Proinflammatory adipokines and cytokines in abdominal obesity as a factor in the development of atherosclerosis and renal pathology
https://doi.org/10.52727/2078-256X-2021-17-4-101-110
Abstract
In recent decades, there has been an increase in the prevalence of overweight and obesity. Obesity has become an underestimated pandemic and a public health threat around the world. Adipose tissue is positioned as an endocrine organ that secretes a wide range of pro-inflammatory cytokines and adipokines, inducing a state of chronic subinflammation. The results of epidemiological studies over the past 30 years have also shown that visceral adipose tissue is an independent risk factor for the development of atherosclerosis, cardiometabolic diseases and chronic kidney disease. We performed a systematic review to summarize important aspects of the state of chronic subinflammation in the context of its effect on the decrease in glomerular filtration rate and the development of chronic kidney disease. The review deals with the etiology and pathogenesis of obesity, the hormonal profile of adipose tissue, the molecular mechanisms of the effect of pro-inflammatory cytokines and adipokines on the kidneys, and the pathophysiology of renal diseases. Information on the topic from publications based on the Pubmed database has been used.
Keywords
abdominal obesity,
atherosclerosis,
adipokines,
cytokines,
glomerular filtration rate,
chronic subinflammation
Supporting agencies: The work was carried out within the framework of the State Assignment on the budgetary theme of research work No. АААА-А17-117112850280-2 and with the financial support of the RFBR grant 19-013-00800 «Long-term trends of overweight among young Russians: an assessment of the contribution of genetic, behavioral and socio-economic factors to the increase in the prevalence of obesity in Russia.»
About the Authors
E. A. Ryabova
Research Institutе of Internal and Preventive Medicine, Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Ekaterina A. Ryabova, 1-year resident in the specialty «Therapy»
630089, Novosibirsk, Boris Bogatkov str., 175/1
I. Y. Ragino
Research Institutе of Internal and Preventive Medicine, Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Yulia I. Ragino, RAS corresponding member, doctor of medical sciences, professor, head of the RIIPM – Branch ICG SB RAS of Internal and Preventive Medicine – Branch of the Federal State Budgetary Institution of Science Federal Research
630089, Novosibirsk, Boris Bogatkov str., 175/1
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Review
For citations:
Ryabova E.A., Ragino I.Y. Proinflammatory adipokines and cytokines in abdominal obesity as a factor in the development of atherosclerosis and renal pathology. Ateroscleroz. 2021;17(4):101-110. (In Russ.) https://doi.org/10.52727/2078-256X-2021-17-4-101-110
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