Prevalence of hypercholesterolemia in young people under 45 years old with abdominal obesity in Novosibirsk
https://doi.org/10.52727/2078-256X-2021-17-4-48-54
Abstract
The study was devoted to the study of the prevalence of hypercholesterolemia (hyper-Chol) and hypercholesterolemia of low density lipoproteins (hyper-LDL-C) against the background of abdominal obesity (AO) in a population aged 25–44 years in Novosibirsk. Material and methods. A crosssectional survey of the population aged 25–44 years in Novosibirsk (Russia) was carried out. 1415 people were examined, including 670 men (47.3 %) and 745 women (52.7 %), pregnant women or being on maternity leave were not included in the study). All subjects were assessed for the presence of AO, hyper-Chol and hyper-LDL-C. Results. Individuals with AO had higher average values of total cholesterol and LDL cholesterol. The prevalence of hyper-Chol in individuals with AO was 1.3 times higher and hyper-LDL-C – 1.2 times higher than in individuals without AO. In women with AO, the prevalence of hyper-Chol was 1.2 times higher and hyper-LDL-C – 1.3 times higher than in women without AO. In men with AO, the prevalence of hyper-Chol was 1.4 times higher and hyper-LDL-C – 1.2 times higher than in men without AO. When conducting logistic regression analysis, it was found that in a young population under 45 years of age, abdominal obesity was significantly associated with the presence of atherogenic hypercholesterolemia in both sexes. In men, significant associations of AO with both hyper-Chol and hyper-LDL-C were noted, in women – only with hyper-LDL-C. Conclusions. A population study of young people (25–44 years old) revealed associations of atherogenic hypercholesterolemia with abdominal obesity.
Supporting agencies: The collection of material was carried out according to the State Assignment on the budgetary theme of research work No. AAAA-A17-117112850280-2, statistical processing and analysis of the material were carried out with the financial support of the RFBR grant No. 19-013-00800 «Long-term dynamics of overweight among young Russians: assessment of the contribution of genetic behavioral and socio-economic factors in the increase in the prevalence of obesity in Russia»
About the Authors
A. N. Spiridonov
Research Institutе of Internal and Preventive Medicine, Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Aleksandr N. Spiridonov, doctor-resident in the specialty «Cardiology»
630089, Novosibirsk, Boris Bogatkov str., 175/1
D. V. Denisova
Research Institutе of Internal and Preventive Medicine, Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Diana V. Denisova, DM, Chief Researcher, laboratory of preventive medicine
630089, Novosibirsk, Boris Bogatkov str., 175/1
Y. I. Ragino
Research Institutе of Internal and Preventive Medicine, Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Iuliia I. Ragino, DM, professor, corresponding member RAS, head research
630089, Novosibirsk, Boris Bogatkov str., 175/1
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For citations:
Spiridonov A.N., Denisova D.V., Ragino Y.I. Prevalence of hypercholesterolemia in young people under 45 years old with abdominal obesity in Novosibirsk. Ateroscleroz. 2021;17(4):48-54. (In Russ.) https://doi.org/10.52727/2078-256X-2021-17-4-48-54
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