BIOLOGICAL RISK FACTORS FOR CHRONIC NON-COMMUNICABLE DISEASES IN MEN WITH VARIOUS CLINICAL AND CORONARY ANGIOGRAPHIC VARIANTS OF ACUTE CORONARY SYNDROME

Purpose of the study was to evaluate the features of biological risk factors for chronic noninfectious diseases in various clinical forms and coronary angiography manifestations of acute coronary syndrome in men.

Material and methods. 77 men with acute coronary syndrome (62 patients with myocardial infarction (MI) and 15 with unstable angina (UA)) were examined. The biological risk factors of chronic non-communicable diseases (RF CNСD) have been investigated: abdominal obesity, dyslipidemia, arterial hypertension, hyperglycemia. All patients underwent emergency coronary angiography.

Results. It has been established that in patients with MI with stenosis of the coronary arteries (CA) ≥75 %, the level of low-density lipoproteins is higher than in UA with CA stenosis <75 %, and the concentration of high-density lipoproteins is lower than in UA with stenosis ≥75 %. In MI with stenosis of CA ≥75 %, the frequency of occurrence of atherogenic index > 3 is higher than with MI with stenosis of CA <75 % and UA with stenosis of CA <75 %. When analyzing the carbohydrate metabolism, it was found that in patients with MI with stenosis ≥75 %, the fasting plasma glucose level has higher than in infarction with narrowing of the CA <75 %, moreover, a direct correlation is shown between the presence of hyperglycemia and the occurrence of CA occlusion. The level of diastolic blood pressure in patients with stenosis ≥75 % and myocardial infarction with stenosis ≥75 % is higher than in patients with congenital stenosis with CA <75 %. With a combination of three or more risk factors, a more significant percentage of stenosis and an increase in the frequency of occlusion of spacecraft is established than with one or two risk factors.

Conclusion. Heavier clinical and coronary angiographic variants of acute coronary syndrome were diagnosed in men with risk factors such as hypercholesterolemia, increased low-density lipoprotein content and atherogenic index, decreased high-density lipoprotein concentration, fasting hyperglycemia and increased diastolic blood pressure. The chance of CA occlusion significantly increased when combining three or more biological RF CNCD. 

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