EFFECT OF FUCOIDAN ON THE LEVEL AND DYNAMIC OF LIPID METABOLISM PARAMETERS IN P-407 INDUCED D YSLIPIDEMIA
Abstract
Purpose: to study the effect of fucoidan (sulfated polysaccharide from brown algae) on the dynamics of lipid metabolism in the mice model of dyslipidemia induced poloxamer P-407. Materials and methods. We used fucoidan, extracted from brown algae Fucus evanescens with a molecular weight 160 kDa. Experimental studies were conducted on noninbred white mice. The model of dyslipidemia and atherosclerosis in animals was induced by intraperitoneal injection of poloxamer 407 (P-407). Results. We revealed the ability of per os administration of fucoidan to normalize the basic parameters of lipid metabolism in mice with dyslipidemia (serum levels of triglyceride, high-density lipoprotein cholesterol and very low-density lipoprotein cholesterol). Conclusion. Revealed experimental results allow to consider the fucoidan as the basis for the development of new biological products with lipid corrective action and to recommend it for further study in experimental and clinical trials.
About the Authors
T. A. Kuznetsova
G.P.Somov Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
E. V. Persiyanova
G.P.Somov Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
I. D. Makarenkova
G.P.Somov Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
N. N. Besednova
G.P.Somov Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
R. V. Menshova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry
Russian Federation
Russian Federation
T. N. Zvyagintseva
G.B. Elyakov Pacific Institute of Bioorganic Chemistry
Russian Federation
Russian Federation
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Review
For citations:
Kuznetsova T.A., Persiyanova E.V., Makarenkova I.D., Besednova N.N., Menshova R.V., Zvyagintseva T.N. EFFECT OF FUCOIDAN ON THE LEVEL AND DYNAMIC OF LIPID METABOLISM PARAMETERS IN P-407 INDUCED D YSLIPIDEMIA. Ateroscleroz. 2016;12(2):5-10. (In Russ.)
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