Triglyceride – glucose index and its derivatives in women of reproductive age with different metabolic phenotypes

In recent years, the theory of metabolic phenotyping has been actively studied, which is based on the identification of metabolically healthy (MHP) and unhealthy phenotypes (MUHP) people with different body mass index (BMI). According to the literature, the basis for the formation of MUHP is insulin resistance (IR). One of the most practically accessible tools for assessing IR is the TyG index and its derivatives. However, there is still insufficient information about the features of IR indicators in individuals with different metabolic phenotypes. Aim is to study the indices of insulin resistance based on the TyG index in a sample of women aged 25–44 in Novosibirsk. Material and methods. A representative sample of women aged 25–44 years living in Novosibirsk was examined, the final sample included 651 women. Study design: a single-stage population-based study. An anthropometric and laboratory examination was performed. The criteria of metabolic syndrome IDF, 2005, were considered as definitions of a metabolically unhealthy phenotype. Statistical processing of the results was carried out in the SPSS for Windows program. Results. Young women with MUHP had significantly higher TyG, TyG-BMI, TyG-WC, TyG-WC/height indices than those with MHP both in the entire sample and when divided into groups by BMI (p < 0.05). With an increase in BMI from normal body weight to obesity, a significant increase in TyG-BMI, TyGWC, TyG-WC/height (p < 0.0001) was revealed, but not the TyG index. When evaluating the ability of the studied indices to recognize the presence of MUHP, models of good (TyG) and excellent quality (TyG-BMI, TyG-WC, TyG-WC/height) were obtained for all indices. The highest quality of the model was obtained for the TyG-WC index (AUC = 0.930, p < 0.0001), the cut-off value for MUHP recognition was 368.3 (Se = 93.8 %, Sp = 79.1 %). Conclusions. Higher TyG-based insulin resistance indices were found in women with MUHP compared with MHP at any body mass index value, the TyG-WC index showed the greatest ability to recognize MUHP in young women.

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