The fatty acid profile of blood plasma in men from rural areas of Novosibirsk region with arterial hypertension
V. S. Shramko,
E. M. Stakhneva,
L. V. Shcherbakova,
E. V. Kashtanova,
A. D. Afanasyeva,
E. V. Garbuzova,
Yu. I. Ragino https://doi.org/10.52727/2078-256X-2026-22-1-73-83
Abstract
Different fatty acids (FA) have different effects on oxidative stress, insulin resistance, inflammation, and endothelial dysfunction, which may eventually contribute to the development of hypertension. Aim – to study the levels of unsaturated FA (UFA) in blood plasma in men aged 35-74 years from rural areas of the Novosibirsk region in the presence of hypertension, as well as to analyze the association of UFA with the presence of hypertension.
Material and methods. Rural residents aged 35-74 were examined as part of a single-center observational single-stage epidemiological study in the Novosibirsk region. The study included 300 men with an average age of 60.4 ± 10.6 years. The levels of UFA in blood plasma were determined by gas chromatography with mass-selective detection: omega-3 (alpha-linolenic, eicosapentaenoic, docosahexaenoic); omega-6 (linoleic, gamma-linolenic, digomo-gamma-linolenic, arachidonic, docosatetraenoic, docosapentaenoic); omega-9 (hexadecenoic, oleic acid, mead, selacholic).
Results. A comparative analysis of the studied indicators using the Kruskal-Wallace test revealed statistically significant differences in the content of linoleic acid (p = 0.043) between the subgroups with hypertension of 1, 2 and 3 degrees. These differences are mainly due to the group of patients with grade 3 hypertension. A detailed study revealed a statistically significant increase in gamma-linolenic acid levels by 16 % and 21 % in the subgroups with grade 2 hypertension (p = 0.046) and grade 3 hypertension (p = 0.014), respectively, compared with the control group. A correlation analysis revealed a direct relationship between gamma-linolenic acid and hypertension (r = 0.152; p = 0.008).
Conclusions. The present study found a direct relationship between the level of omega-6 gamma-linolenic acid and the severity of hypertension in men aged 35–74 years from rural areas of Novosibirsk region.
Supporting agencies: The work was carried out within the framework of the budget theme under the State Assignment No. FWNR-2024-0004 and with the support of a grant from the Government of the Novosibirsk Region No. 10-2025-034764.
About the Authors
V. S. Shramko
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Viktoriya S. Shramko, candidate of medical sciences, researcher at the laboratory of clinical biochemical and hormonal studies of therapeutic diseases, head of the department of clinical-biochemical and molecular genetic research methods
175/1, Boris Bogatkov st., Novosibirsk, 630089
E. M. Stakhneva
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Ekaterina M. Stakhneva, candidate of biological sciences, senior researcher at the laboratory of clinical biochemical and hormonal studies of therapeutic diseases, head of the department of clinical-biochemical and molecular genetic research methods
175/1, Boris Bogatkov st., Novosibirsk, 630089
L. V. Shcherbakova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Lilia V. Shcherbakova, senior researcher at the laboratory of clinical, population and preventive research of therapeutic and endocrine diseases, head of the department of extra-budgetary works
175/1, Boris Bogatkov st., Novosibirsk, 630089
E. V. Kashtanova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena V. Kashtanova, doctor of biological sciences, senior researcher at the laboratory of clinical biochemical and hormonal studies of therapeutic diseases, head of the department of clinical-biochemical and molecular genetic research methods
175/1, Boris Bogatkov st., Novosibirsk, 630089
A. D. Afanasyeva
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Alena D. Afanasyeva, candidate of medical sciences, head of the laboratory of genetic and environmental determinants of the human life cycle
175/1, Boris Bogatkov st., Novosibirsk, 630089
E. V. Garbuzova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Evgenia V. Garbuzova, candidate of medical sciences, senior researcher at the laboratory of genetic and environmental determinants of the human life cycle
175/1, Boris Bogatkov st., Novosibirsk, 630089
Yu. I. Ragino
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Yulia I. Ragino, doctor of medical sciences, professor, corresponding member of the russian academy of sciences, head; chief researcher at the laboratory of clinical biochemical and hormonal studies of therapeutic diseases
175/1, Boris Bogatkov st., Novosibirsk, 630089
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For citations:
Shramko V.S., Stakhneva E.M., Shcherbakova L.V., Kashtanova E.V., Afanasyeva A.D., Garbuzova E.V., Ragino Yu.I. The fatty acid profile of blood plasma in men from rural areas of Novosibirsk region with arterial hypertension. Ateroscleroz. 2026;22(1):73-83. (In Russ.) https://doi.org/10.52727/2078-256X-2026-22-1-73-83
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