Associations of proinflammatory cytokines of visceral adipose tissue with metabolic disorders in abdominal obesity
https://doi.org/10.52727/2078-256X-2025-21-3-320-329
Abstract
The aim. To identify associations between proinflammatory cytokines of visceral adipose tissue with metabolic disorders in abdominal obesity.
Materials and methods. The study was conducted on 101 people aged 25–65 years. Questionnaires, anthropometry, blood pressure measurements, as well as fasting blood sampling and visceral adipose tissue biopsies during elective surgery were conducted. Enzymatic methods were used to determine the parameters of the lipid profile and glucose in the blood. Homogenates were prepared from biopsies of visceral adipose tissue. The level of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocytic chemoattractant protein-1 (MCP-1) was determined in blood and obtained homogenates of adipose tissue by multiplex analysis.
Results. A weak positive relationship was found between serum IL-6 levels and adipose tissue. A weak positive relationship was found between IL-6 visceral adipose tissue and the VAI index, as well as between MCP-1 visceral adipose tissue and the LAP and VAI indices. The level of MCP-1 in visceral adipose tissue is directly associated with the LAP insulin resistance index (6,255 [1,648; 10,862], p = 0.008), TNF-α – with the VAI insulin resistance index (1,076 [0.335; 1,817], p = 0.005).
Conclusion. Of the proinflammatory cytokines we studied, an association with insulin resistance was shown for MCP-1 and TNF-α visceral adipose tissue. At the same time, MCP-1 is directly associated with the LAP index, and TNF-α is directly associated with the VAI index.
About the Authors
O. V. Tuzovskaya
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Olga V Tuzovskaia, research assistant at the laboratory of genetic and environmental determinants of the human life cycle
175/1, Boris Bogatkov st., Novosibirsk, 630089
Ya. V. Polonskaya
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Yana V. Polonskaya, doctor of biological sciences, senior researcher at the laboratory of clinical biochemical and hormonal studies jn internal diseases
175/1, Boris Bogatkov st., Novosibirsk, 630089
E. V. Garbuzova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Evgeniia V. Garbuzova, candidate of medical sciences, researcher at the laboratory of genetic and environmental determinants of the human life cycle
175/1, Boris Bogatkov st., Novosibirsk, 630089
E. V. Kashtanova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena V. Kashtanova, doctor of biological sciences, head of the laboratory of clinical biochemical and hormonal studies on internal diseases
175/1, Boris Bogatkov st., Novosibirsk, 630089
Yu. I. Ragino
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Yulia I. Ragino, doctor of medical sciences, Professor, corresponding member of the RAS, head
175/1, Boris Bogatkov st., Novosibirsk, 630089
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For citations:
Tuzovskaya O.V., Polonskaya Ya.V., Garbuzova E.V., Kashtanova E.V., Ragino Yu.I. Associations of proinflammatory cytokines of visceral adipose tissue with metabolic disorders in abdominal obesity. Ateroscleroz. 2025;21(3):320-329. (In Russ.) https://doi.org/10.52727/2078-256X-2025-21-3-320-329
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