Professor, Doctor of Sciences (Medicine), Corresponding Member of the Russian Academy of Sciences

Head of the Institute of Internal and Preventive Medicine, a branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences

Major areas of expertise

The main field of Yu.I. Ragino's activity is the investigation of atherosclerosis. She is an expert in the biochemistry and pathophysiology of common cardiovascular diseases.

Major scientific achievements

Yuliya I. Ragino studied and identified key biochemical markers and mechanisms of the formation of various types of unstable atherosclerotic plaques in atherosclerosis; developed methods for early biochemical detection of atherosclerosis and assessment of the risk of the acute coronary syndrome; developed a method of assessing the probability of the presence of unstable atherosclerotic plaques in coronary arteria; determined the key role of biomolecules associated with the secretory activity of abdominal adipocytes in the development of early ischemic heart disease in persons under 45 years; developed the concept of unidirectional highly atherogenic changes in oxidatively and structurally modified blood lipoproteins, including small dense atherogenic subfractions, in clinically apparent atherosclerosis and its major risk factors; and studied the atherogenic properties of oxidized proteins and their role in atherogenesis. She proposed new criteria for assessing the efficiency of the pharmacological correction of a disease.

Research management and educational work

Member of the board of the Russian National Atherosclerotic Society. Chairman of the Medical Research Council of the Institute of Internal and Preventive Medicine.

Chairman of the Dissertation Council D.003.011.02

Principal Investigator in two projects of the Russian Foundation for Basic Research, a grant from the RF President for leading academic schools, and a grant from the Russian Science Foundation.

Editorial activity

Journal Ateroskleroz (Atherosclerosis): Deputy Editor-in-Chief since 2010 and Editor-in-Chief since 2021.

Sibirskiy nauchnyy meditsinskiy zhurnal (The Siberian Scientific Medical Journal): Member of the Editorial Board since 2019 and Editor-in-Chief since 2021.

List of publications

Yuliya I. Ragino published over 400 research papers, including 8 monographs, over 300 articles, and 8 patents of invention.

1. Striukova E.V., Maksimov V.N., Ragino Yu.I., Polonskaya Ya.V., Murashov I.S., Volkov A.M., Kurguzov A.V., Chernyavsky A.M., Kashtanova E.V. Polymorphisms in the CETP, APOC3 and APOE genes in men with unstable atherosclerotic plaques in the coronary arteries. MetaGene. 2021; 27: 100847. https://doi.org/10.1016/j.mgene.2020.100847
2. Ragino Yu.I., Kuzminykh N.A., Shcherbakova L.V., Shramko V.S., Denisova D.V. Prevalence of early ischemic heart disease and its associations with risk factors and socioeconomic variablesin the 25–44-year age group in Novosibirsk. Int. J. Cardiovasc. Dis. Diagn. 2021; 6 (1): 001-08.
3. Mustafina S.V., Rymar O.D., Shcherbakova L.V., Verevkin E.G., Pikhart H., Sazonova O.V., Ragino Yu.I., Simonova G.I., Bobak M., Malyutina S.K., Voevoda M.I. The risk of type 2 diabetes mellitus in a russian population cohort according to data from the HAPIEE project. J. Pers. Med. 2021, 11 (2): 119. https://doi.org/10.3390/jpm11020119
4. Striukova E.V., Maksimov V.N., Ragino Yu.I., Polonskaya Ya.V., Murashov I.S., Volkov A.M., Kurguzov A.V., Chernjavskii A.M., Kashtanova E.V. Polymorphisms in CCL2 and IL6 genes in men with unstable atherosclerotic plaques in the coronary arteries. J. Cardiovasc. Dis. Res. 2021, 12 (1): 68–74. https://doi.org/10.31838/jcdr.2021.12.01.16
5. Polonskaya Ya.V., Kashtanova E.V., Murashov I.S., Striukova E.V., Kurguzov A.V., Stakhneva E.M., Shramko V.S., Maslatsov N.A., Chernyavsky A.M., Ragino Yu.I. Association of matrix metalloproteinases with coronary artery calcification in patients with CHD. J. Pers. Med. 2021; 11: 506. https://doi.org/10.3390/jpm11060506
6. Kirichenko T.V., Ragino Yu.I., Voevoda M.I., Urazalina S.J., Khasanova Z.B., Orekhova V.A., Sinyov V.V., Sazonova M.A., Orekhov A.N., Sobenin I.A.. Data on association of mitochondrial heteroplasmy with carotid intima-media thickness in subjects from Russian and Kazakh populations. Data in Brief. 2020; 29: 105–136. https://doi.org/10.1016/j.dib.2020.105136
7. Stakhneva E.M., Meshcheryakova I.A., Demidov E.A., Starostin K.V., Peltek S.E., Voevoda M.I., Ragino Yu.I. Changes in the proteomic profile of blood serum in coronary atherosclerosis. J. Med. Biochem. 2020; 39 (2): 208–214. https://doi.org/10.2478/jomb-2019-0022
8. Ragino Yu.I., Shramko V.S., Stakhneva E.M., Chernyak E.I., Morozov S.V., Shakhtshneider E.V., Polonskaya Ya.V., Shcherbakova L.V., Chernyavskiy A.M. Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis. J. Med. Biochem. 2020; 39 (1): 46–53. https://doi.org/10.2478/jomb-2019-0010
9. Ragino Y.I., Stakhneva E.M., Polonskaya Y.V., Kashtanova E.V. The role of secretory activity molecules of visceral adipocytes in abdominal obesity in the development of cardiovascular disease: a review. Biomolecules. 2020; 10 (3): 374. https://doi.org/10.3390/biom10030374
10. Lakunchykova O., Averina M., Wilsgaard T., Watkins H., Malyutina S., Ragino Yu., Keogh R.H., Kudryavtsev A.V., Govorun V., Cook S., Schirmer H., Eggen A.E., Hopstock L.A., Leon D.A. Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage. J. Epidemiol. Community Health. 2020; 74 (9): 698-704. https://doi.org/10.1136/jech-2020-213885
11. Shramko V.S., Polonskaya Y.V., Kashtanova E.V., Stakhneva E.M., Ragino Y.I. The short overview on the relevance of fatty acids for human cardiovascular disorders. Biomolecules. 2020, 10: 1127. https://doi.org/10.3390/biom10081127
12. Ragino Y.I., Oblaukhova V.I., Polonskaya Y.V., Kuzminykh N.A., Shcherbakova L.V., Kashtanova E.V. The blood cytokine profile of young people with early ischemic heart disease comorbid with abdominal obesity. J. Pers. Med. 2020, 10 (3), 87. https://doi.org/10.3390/jpm10030087
13. Kirichenko T.V., Ryzhkova A.I., Sinyov V.V., Sazonova M.D., Orekhova V.A., Karagodin V.P., Gerasimova E.V., Voevoda M.I., Orekhov A.N., Ragino Y.I., Sobenin I.A., Sazonova M.A. Impact of mitochondrial DNA mutations on carotid intima-media thickness in the Novosibirsk region. Life. 2020; 10 (9): 160. https://doi.org/10.3390/life10090160
14. Ivanoshchuk D.E., Shakhtshneider E.V., Rymar O.D., Ovsyannikova A.K., Mikhailova S.V., Orlov P.S., Ragino Y.I., Voevoda M.I. Analysis of APPL1 gene polymorphisms in patients with a phenotype of maturity onset diabetes of the young. J. Pers. Med. 2020; 10 (3): 100. https://doi.org/10.3390/jpm10030100 
15. Polonskaya Ya.V., Kashtanova E.V., Murashov I.S., Kurguzov A.V., Sadovski E.V., Maslatsov N.A., Stakhneva E.M., Chernyavskii A.M. and Ragino Yu.I. the influence of calcification factors and endothelial-dysfunction factors on the development of unstable atherosclerotic plaques Diagnostics. 2020; 10 (12): 1074. https://doi.org/10.3390/diagnostics10121074
16. Tsygankova O.V., Evdokimova N.E., Ragino Yu.I., Nikolaev K.Yu., Latyntseva L.D., Veretyuk V.V. Coronary artery calcification parameters in patients with coronary artery disease, depending on age, sex, and sex hormone levels. World Heart J. 2020; 12 (4): 287-298.
17. Ragino Yu.I., Striukova E.V., Murashov I.S., Polonskaya Ya.V., Volkov A.M., Kurguzov A.V., Chernjavskii A.M., Kashtanova E.V. Association of some hemostasis and endothelial dysfunction factors with probability of presence of vulnerable atherosclerotic plaques in patients with coronary atherosclerosis. BMC Res. Notes, 2019; 12 (1): 336. https://doi.org/10.1186/s13104-019-4360-7
18. Shakhtshneider E., Orlov P., Semaev S., Ivanoshchuk D., Malyutina S., Gafarov V., Ragino Yu., Voevoda M. Analysis of polymorphism rs1333049 (located at 9P21.3) in the white population of Western Siberia and associations with clinical and biochemical markers. Biomolecules. 2019; 9 (7): 290. https://doi.org/10.3390/biom9070290
19. Stakhneva E.M., Meshcheryakova I.A., Demidov E.A., Starostin K.V., Sadovski E.V., Peltek S.E., Voevoda M.I., Chernyavskii A.M., Volkov A.M., Ragino Yu.I. A proteomic study of atherosclerotic plaques in men with coronary atherosclerosis. Diagnostics. 2019; 9 (4): 177. https://doi.org/10.3390/diagnostics9040177
20. Semaev S., Shakhtshneider E., Orlov P., Ivanoshchuk D., Malyutina S., Gafarov V., Ragino Yu., Voevoda M. Association of RS708272 (CETP gene variant) with lipid profile parameters and the risk of myocardial infarction in the white population of Western Siberia. Biomolecules 2019; 9 (7): 739. https://doi.org/10.3390/biom9110739
21. Polonskaya Ya.V., Kashtanova E.V., Stryukova E.V., Volkov A.M., Murashov I.S., Chernyavsky А.М., Ragino Y.I. Dynamics of changes in concentration of inflammatory and destructive biomarkers at various stages of atherosclerotic plaque development. Journal of Cardiology and Clinical Practice. 2018; 1 (2): 1–5. https://researchopenworld.com/dynamics-of-changes-in-concentration-of-inflammatory-and-destructive-biomarkers-at-various-stages-of-atherosclerotic-plaque-development/
22. Shakhtshneider E.V., Mikhailova S.V., Ivanoshchuk D.E., Orlov P.S., Ovsyannikova A.K., Rymar O.D., Ragino Yu.I., Voevoda M.I. Polymorphism of the GLIS3 gene in a Caucasian population and among individuals with carbohydrate metabolism disorders in Russia. BMC Res. Notes. 2018; 11: 211-215. https://doi.org/10.1186/s13104-018-3338-1
23. Bekenev V.A., Garcia A., Arishin A.A., Ragino Yu.I., Polonskaya Ya.V., Bolshakova I.V. The ratio of qualitative indicators of pork with lipid metabolism in pigs of different breeds. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2018; 9 (5): 2326-2334.
24. Shramko V.S., Polonskaya Ya.V., Morozov S.V., Chernyak E.I., Chernyavsky A.M., Ragino Yu.I. Polyunsaturated fatty acids and their correlations with parameters of oxidative/antioxidant potential of the blood and lipoprotein-associated phospholipase A2 in coronary atherosclerosis. Bull. Exp. Biol. Med. 2018; 166 (1): 11-14. https://doi.org/ 0.1007/s10517-018-4277-5
25. Polonskaya Ya.V., Shramko V.S., Morozov S.V., Chernyak E.I., Chernyavsky A.M., Ragino Yu.I. Balance of fatty acids and their correlations with parameters of lipid metabolism and markers of inflammation in men with coronary atherosclerosis. Bull. Exp. Biol. Med. 2017; 164 (1): 33-35. https://doi.org/10.1007/s10517-017-3920-x