Features of the course of acute coronary syndrome in medical workers who have undergone a new coronavirus infection
L. A. Shpagina,
V. A. Kozik,
I. S. Shpagin,
I. I. Logvinenko,
K. V. Likhenko-Logvinenko,
L. A. Panacheva,
S. A. Karmanovskaya,
O. S. Kotova,
V. A. Drobyshev,
A. M. Lyashenko,
A. A. Rukavitsyna,
E. M. Loktin,
E. G. Kondyurina,
V. V. Zelenskaya,
T. V. Kiseleva https://doi.org/10.52727/2078-256X-2023-19-2-107-114
Abstract
Both in Russia and worldwide, morbidity and mortality from acute coronary syndrome (ACS) remain high. The emergence of a new coronavirus infection, the active participation of medical workers in its elimination, determined a new phenotype of patients, which determines the relevance of the problem and of a more detailed assessment of this cohort of patients. Aim of the study was to identify and determine the clinical and functional features, phenotype and endotype of the course of ACS in medical workers who have had a new coronavirus infection. Material and methods. An open cohort comparative study was conducted. It included 60 healthcare workers with ACS and a previous novel coronavirus infection, who were selected based on the identification of SARS-CoV-2 and/or its antibodies (positive PCR test) in anamnesis. All patients were admitted to the regional vascular center № 7 of the City Clinical Hospital № 2, Novosibirsk. The comparison group consisted of 60 healthcare workers with ACS without positive PCR test in anamnesis. General clinical and instrumental, coronary angiography with possible stenting. Results. Of the 60 medical workers with ACS after a new coronavirus infection, myocardial infarction with ST segment elevation was detected in 21 people, myocardial infarction without ST segment elevation – in 31, unstable angina pectoris – in 8 people. Within 6 months of undergoing COVID-19, they developed complex rhythm disorders, such as paroxysm of fibrillation or atrial flutter, more frequently than in the comparison group, as well as a full AV-blockade (n = 25, 41.6 %, p = 0.020), bradyarrhythmias and conductivity disturbances (n = 8, 13.3 %, p = 0.045), revealed a more than 2-fold increase in the pro-brain natriuretic peptide (proBNP) (n = 21, 35 %, p = 0.033), observed myocardial dysfunction (ejection fraction less than 50 %) (n = 6, 10 %, p = 041). Conclusions. The data obtained indicate the formation of a new ACS phenotype in medical workers who have undergone a new coronavirus infection.
About the Authors
L. A. Shpagina
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Lyubov A. Shpagina, doctor of medical sciences, professor, head of the Department of Hospital Therapy and Medical Rehabilitation
52, Krasny prospect, Novosibirsk, 630091
V. A. Kozik
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Valentina A. Kozik, candidate of medical sciences, assistant of the Department of Hospital Therapy and Medical Rehabilitation
52, Krasny prospect, Novosibirsk, 630091
I. S. Shpagin
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Ilya S. Shpagin, doctor of medical sciences, professor of the Department of Hospital Therapy and Medical
Rehabilitation
52, Krasny prospect, Novosibirsk, 630091
I. I. Logvinenko
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Irina I. Logvinenko, doctor of medical sciences, professor of the Department of Emergency Therapy with
Endocrinology and Occupational Pathology (EPC and OPV)
52, Krasny prospect, Novosibirsk, 630091
K. V. Likhenko-Logvinenko
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Kristina V. Likhenko-Logvinenko, PhD student, Department of Hospital Therapy and Medical Rehabilitation
52, Krasny prospect, Novosibirsk, 630091
L. A. Panacheva
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Lyudmila A. Panacheva, doctor of medical sciences, professor of the Department of Hospital Therapy and Medical Rehabilitation
52, Krasny prospect, Novosibirsk, 630091
S. A. Karmanovskaya
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Svetlana A. Karmanovskaya, doctor of medical sciences, associate professor, Department of Hospital Therapy and
Medical Rehabilitation
52, Krasny prospect, Novosibirsk, 630091
O. S. Kotova
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Olga S. Kotova, doctor of medical sciences, associate professor, Department of Hospital Therapy and Medical
Rehabilitation
52, Krasny prospect, Novosibirsk, 630091
V. A. Drobyshev
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Victor A. Drobyshev, doctor of medical sciences, professor of the Department of Hospital Therapy and Medical Rehabilitation
52, Krasny prospect, Novosibirsk, 630091
A. M. Lyashenko
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Artem M. Lyashenko, assistant of the Department of Radiation Diagnostics (Dental Faculty)
52, Krasny prospect, Novosibirsk, 630091
A. A. Rukavitsyna
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Anastasia A. Rukavitsina, assistant of the Department of Nursing (Faculty of Medicine)
52, Krasny prospect, Novosibirsk, 630091
E. M. Loktin
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Evgeniy M. Loktin, doctor of medical sciences, professor of the Department of Anesthesiology and Resuscitation
of the Medical Faculty
52, Krasny prospect, Novosibirsk, 630091
E. G. Kondyurina
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Elena G. Kondyurina, doctor of medicine, professor, head of the Department of Pediatrics, Faculty of Advanced
Training and Professional Retraining of Physicians
52, Krasny prospect, Novosibirsk, 630091
V. V. Zelenskaya
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Vera V. Zelenskaya, doctor of medical sciences, professor of the Department of Pediatrics, Faculty of Advanced
Training and Professional Retraining of Physicians
52, Krasny prospect, Novosibirsk, 630091
T. V. Kiseleva
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Tatyana V. Kiseleva, doctor of medical sciences, professor of the Department of Obstetrics and Gynecology) of the
Faculty of Medicine
52, Krasny prospect, Novosibirsk, 630091
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Review
For citations:
Shpagina L.A., Kozik V.A., Shpagin I.S., Logvinenko I.I., Likhenko-Logvinenko K.V., Panacheva L.A., Karmanovskaya S.A., Kotova O.S., Drobyshev V.A., Lyashenko A.M., Rukavitsyna A.A., Loktin E.M., Kondyurina E.G., Zelenskaya V.V., Kiseleva T.V. Features of the course of acute coronary syndrome in medical workers who have undergone a new coronavirus infection. Ateroscleroz. 2023;19(2):107-114. (In Russ.) https://doi.org/10.52727/2078-256X-2023-19-2-107-114
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