The role of polymorphisms within genes encoding Toll-like receptors in coronary atherosclerosis
Abstract
Study aim: To investigate an association of the Toll-like receptor (TLR) gene polymorphisms with the risk of coronary artery disease (CAD). Materials and
Methods: We recruited 702 consecutive Russian patients with CAD and 300 healthy blood donors who were residents of Western Siberia (Kemerovo Region). We investigated eight polymorphisms within four genes: TLR1 (rs5743551, rs5743611), TLR2 (rs3804099, rs5743708), TLR4 (rs4986790, rs4986791), and TLR6 (rs3775073, rs5743810). Sample genotyping was performed in 96-well format using the TaqMan SNP genotyping assay.
Results: C/C genotype of rs5743551 polymorphism and C/G genotype of rs5743611 polymorphism within TLR1 gene along with T/C genotype of rs3775073 polymorphism and A/G genotype of rs5743810 polymorphism within TLR6 gene were associated with a high risk of coronary artery disease
(OR = 0.41 (95 % CI = 0.20–0.84), OR = 1.56, 95 % CI = 1.04–2.34, OR = 1.68, 95 % CI = 1.03–2.73, and OR = 1.55 (95 % CI = 1.12–2.14, р < 0,05, respectively) independently of age and gender.
Conclusions: certain Toll-like receptor gene polymorphisms are associated with the risk of CAD.
About the Authors
A. V. Ponasenko
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
650002
Sosnovy blvd., 6
Kemerovo
M. V. Khutornaya
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
650002
Sosnovy blvd., 6
Kemerovo
A. G. Kutikhin
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
650002
Sosnovy blvd., 6
Kemerovo
I. I. Zhidkova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
650002
Sosnovy blvd., 6
Kemerovo
A. S. Golovkin
Federal North-West Medical Research Centre
Russian Federation
Russian Federation
197341
Akkuratov str., 2
St. Petersburg
O. L. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
650002
Sosnovy blvd., 6
Kemerovo
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Review
For citations:
Ponasenko A.V., Khutornaya M.V., Kutikhin A.G., Zhidkova I.I., Golovkin A.S., Barbarash O.L. The role of polymorphisms within genes encoding Toll-like receptors in coronary atherosclerosis. Ateroscleroz. 2015;11(3):22-28. (In Russ.)
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