Dental infections and their possible impact on the development of atherosclerosis and its complications
Abstract
This review presents the study of the association of parodontal infections with cardiovascular diseases (CVD). The results of studies conducted in the last decade and a half are shown, including systematic reviews and meta-analyzes. Some evidence exists concerning impact of infectious diseases of the oral cavity (caries and its complications, periodontal inflammation) on the onset and progression of the atherosclerotic process. An important measure for prevention of CVD may be adequate oral hygiene.
About the Authors
O. V. ReshetnikovRussian Federation
630089
Boris Bogatkov str., 175/1
Novosibirsk
S. A. Kurilovich
Russian Federation
630089
Boris Bogatkov str., 175/1
Novosibirsk
Yu. P. Nikitin
Russian Federation
630089
Boris Bogatkov str., 175/1
Novosibirsk
References
1. Packard R. R., Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction // Clin. Chem. 2008. Vol. 54. P. 24–38.
2. Rosenfeld M. E. Inflammation and atherosclerosis: direct versus indirect mechanisms // Curr. Opin. Pharmacol. 2013. Vol. 13. P. 154–160.
3. Shetty D., Dua M., Kumar K. et al. Oral hygiene status of individuals with cardiovascular diseases and associated risk factors // Clin. Pract. 2012. Vol. 2. P. e86.
4. Папапаноу П. Н. Связь пародонтита и атеросклероза сосудов: актуальные данные и значимость для специалистов и общества / П. Н. Папапаноу // Лечащий врач. – 2013. – № 7. – С. 44.
5. Verstraelen H., Swidsinski A. The biofilm in bacterial vaginosis: implications for epidemiology, diagnosis and treatment // Curr. Opin. Infect. Dis. 2013. Vol. 26. P. 86–89.
6. Moye Z. D., Zeng L., Burne R. A. Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans // J. Oral. Microbiol. 2014. Vol. 6. 24878. http://dx.doi.org/10.3402/jom.v6.24878.
7. Lalla E., Lamster I. B., Drury S. Hyperglycemia, glycoxidation and receptor for advanced glycation endproducts: potential mechanisms underlying diabetic complications, including diabetes-associated periodontitis // Periodontol. 2000. Vol. 23. P. 50–62.
8. Southerland J. H., Moss K., Taylor G. W. et al. Periodontitis and diabetes associations with measures of atherosclerosis and CHD // Atherosclerosis. 2012. Vol. 222. P. 196–201.
9. Mattila K. J., Nieminen M. S., Valtonen V. V. et al. Association between dental health and acute myocardial infarction // BMJ. 1989. Vol. 298. P. 779–781.
10. Li X., Kolltveit K. M., Tronstad L., Olsen I. Systemic diseases caused by oral infection // Clin. Microbiol. Rev. 2000. Vol. 13. P. 547–558.
11. Heimdahl A., Hall G., Hedberg M. et al. Detection and quantification by lysis-filtration of bacteremia after different oral surgical procedures // J. Clin. Microbiol. 1990. Vol. 28. P. 2205–2209.
12. Haraszthy V. I., Zambon J. J., Trevisan M. et al. Identification of periodontal pathogens in atheromatous plaques // J. Periodontol. 2000. Vol. 71. P. 1554–1560.
13. Joshipura K. J., Wand H. C., Merchant A. T., Rimm E. B. Periodontal disease and biomarkers related to cardiovascular disease // J. Dent. Res. 2004. Vol. 83. P. 151–155.
14. Ramirez H., Arce R., Contreras A. Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial // Trials. 2011. Vol. 12. P. 46. http://www.trialsjournal.com/content/12/1/46
15. Holtfreter B., Empen K., Glдser S. et al. Periodontitis is associated with endothelial dysfunction in a general population: A cross-sectional study // PLоS ONE. 2013. Vol. 8. P. e84603.
16. Reyes L., Herrera D., Kozarov E. et al. Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology // J. Clin. Periodontol. 2013. Vol. 40 (Suppl. 14). P. S30–S50.
17. Bahekar A. A., Singh S., Saha S. The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis // Am. Heart J. 2007. Vol. 154. P. 830–837.
18. Tonetti M. S., D’Aiuto F., Nibali L. el al. Treatment of periodontitis and endothelial function // N. Engl. J. Med. 2007. Vol. 356. P. 911–920.
19. Seinost G., Wimmer G., Skerget M. et al. Periodontal treatment improves endothelial dysfunction in patients with severe periodontitis // Am. Heart J. 2005. Vol. 149. P. 1050–1054.
20. Higashi Y., Goto C., Hidaka T. et al. Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease // Atherosclerosis. 2009. Vol. 206. P. 604–610.
21. Altman D. G., Schulz K. F., Moher D. et al. The revised CONSORT statement for reporting randomized trials: explanation and elaboration // Ann. Intern. Med. 2001. Vol. 134. P. 663–694.
Review
For citations:
Reshetnikov O.V., Kurilovich S.A., Nikitin Yu.P. Dental infections and their possible impact on the development of atherosclerosis and its complications. Ateroscleroz. 2015;11(1):74-80. (In Russ.)