The contribution of Toll-like receptor genes in the etiopathogenesis of coronary artery disease
Abstract
The article presents a review of current meta-analyses on innate immune receptor gene polymorphisms, such as Toll-like receptors, and their potential role in the pathogenesis of coronary atherosclerotic lesions. TLR signaling pathways, as well as available allelic variations of genes encoding them, and the relationship between TLR polymorphic variants with different pathological conditions have been described. The article reveals significant associations of individual TLR gene alleles with the development and progression of atherosclerosis in different populations. However, the research in this area is rather limited and requires further study.
About the Authors
V. A. Ipatova
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute for Complex Issues of Cardiovascular Diseases
650002
Sosnovy Blvd., 6
Kemerovo
A. V. Ponasenko
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute for Complex Issues of Cardiovascular Diseases
650002
Sosnovy Blvd., 6
Kemerovo
M. V. Khutornaya
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute for Complex Issues of Cardiovascular Diseases
650002
Sosnovy Blvd., 6
Kemerovo
A. V. Tsepokina
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute for Complex Issues of Cardiovascular Diseases
650002
Sosnovy Blvd., 6
Kemerovo
A. S. Golovkin
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute for Complex Issues of Cardiovascular Diseases
650002
Sosnovy Blvd., 6
Kemerovo
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For citations:
Ipatova V.A., Ponasenko A.V., Khutornaya M.V., Tsepokina A.V., Golovkin A.S. The contribution of Toll-like receptor genes in the etiopathogenesis of coronary artery disease. Ateroscleroz. 2014;10(4):10-18. (In Russ.)
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