Сell aspects of chronic noninfectious diseases pathogenesis
Abstract
Caveolae are plasma membrane invaginations of the majority of differentiated cells. They are especially abundant in endothelial cells, adipocytes, muscle cells, and fibroblasts. Caveolae membrane is enriched in cholesterol, sphingolipids, and their principal structural protein component caveolins (1, 2, and 3). In numerous studies caveolae and caveolins important role in a variety of cellular functions including endocytic processes, lipid homeostasis, signal transduction, and tumor suppression was demonstrated. Generation of caveolindeficient mice allowed to analyze functions of caveolae and caveolins with respect to human physiology. In the recent years evidences of caveolins implicating in the pathogenesis of human diseases, including atherosclerosis, diabetes type 2, cancer, muscular dystrophies are accumulated. In a review the role of caveolae and caveolins in health and disease is described.
About the Authors
Yu P. Nikitin
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of therapy Internal and preventive medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
E. N. Vorobyova
Altai State Medical University; Research Institute of therapy
Russian Federation
Russian Federation
656049
Lenin str., 40
Barnaul
G. I. Simonova
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of therapy Internal and preventive medicine
630089
Boris Bogatkov str., 175/1
656049
Lenin str., 40
Barnaul
Research Institute of therapy
Novosibirsk
R. I. Vorobyov
Research Institute of therapy
Russian Federation
Russian Federation
Altai laboratory of epidemiology, prognosis and prevention
656049
Lenin str., 40
Barnaul
A. S. Kazyzaeva
Altai State Medical University
Russian Federation
Russian Federation
656049
Lenin str., 40
Barnaul
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Review
For citations:
Nikitin Yu.P., Vorobyova E.N., Simonova G.I., Vorobyov R.I., Kazyzaeva A.S. Сell aspects of chronic noninfectious diseases pathogenesis. Ateroscleroz. 2014;10(1):56-66. (In Russ.)
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