Association of arterial stiffness with components of metabolic syndrome
Abstract
Now to the independent predictors of cardiovascular events include indicators of arterial stiffness. It is shown that the arterial stiffness and, in particular, pulse wave velocity is increased in patients with the metabolic syndrome. It is of interest to what exactly the components of the metabolic syndrome, regardless of age is associated pulse wave velocity. We studied 63 individuals (45 women and 18 men) aged 56–78 years. The components of the metabolic syndrome was determined according to the criteria of ВНОК 2009. Pulse wave velocity in the carotid-femoral segment determined the device SphygmoCor. When analyzing the data in univariate model was registered significant association of pulse wave velocity with the age of participants (p = 0.001), hypertension (p = 0.009) and hypertriglyceridemia (p = 0.004). Multivariate analysis with the simultaneous inclusion in the model variables such as age, sex, abdominal obesity, hypertension, hypertriglyceridemia, hypo-alpha-cholesterolemia, hyper-beta-cholesterolemia, fasting hyperglycemia, has revealed that out of all of these components of the metabolic syndrome, a significant independent determinant of pulse wave velocity, along with age (p = 0.008) are only hypertriglyceridemia (p = 0.024).
About the Authors
A. A. Kuznetsov
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"
630089
st. Boris Bogatkov, 175/1
Novosibirsk
K. N. Khristoforov
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"
630089
st. Boris Bogatkov, 175/1
Novosibirsk
A. V. Sukhanov
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"
630089
st. Boris Bogatkov, 175/1
Novosibirsk
Yu. I. Ragino
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"
630089
st. Boris Bogatkov, 175/1
Novosibirsk
M. V. Ivanova
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"
630089
st. Boris Bogatkov, 175/1
Novosibirsk
S. N. Duma
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"
630089
st. Boris Bogatkov, 175/1
Novosibirsk
V. V. Gafarov
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"
630089
st. Boris Bogatkov, 175/1
Novosibirsk
M. I. Voevoda
RAMS
Russian Federation
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Therapy and Preventive Medicine"
630089
st. Boris Bogatkov, 175/1
Novosibirsk
References
1. Mattace-Raso F. U., van der Cammen T. J., Hofman A., van Popele N. M., Bos M. L., Schalekamp M. A., Asmar R., Reneman R. S., Hoeks A. P., Breteler M. M., Witteman J. C. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study // Circulation. 2006. Vol. 113, N 5. P. 657–663.
2. Mitchell G. F., Hwang S. J., Vasan R. S., Larson M. C., Pencina M. J., Hamburg N. M., Vita J. A., Levy D., Benjamin E. J. Arterial stiffness and cardiovascular events: the Framingham Heart Study // Circulation. 2010. Vol. 121, N 4. P. 505–511.
3. Huang Q. F., Sheng C. S., Liu M. et al. Arterial Stiffness and Wave Reflections in Relation to Plasma Advanced Glycation End Products in a Chinese Population // Am. J. Hypertens. 2013. Vol. 26, N 6. P. 754–761.
4. Олейников В. Э. Влияние ингибитора АПФ спираприла на структурно-функциональные свойства сосудистой стенки при метаболическом синдроме и эссенциальной гипертонии / В. Э. Олейников [и др.] // Рос. кардиол. журн. – 2006. – Т. 58, № 2. – C. 36–41.
5. Li C. I., Kardia S. L., Liu C. S. et al. Metabolic syndrome is associated with change in subclinical arterial stiffness: a community-based Taichung community health study // BMC Public Health. 2011. Vol. 11. P. 808.
6. Safar M. E., Balkau B., Lange C. et al. Hypertension and vascular dynamics in men with metabolic syndrome // J. Am. Coll. Cardiol. 2013. Vol. 61, N 1. P. 12–19.
7. Lee M. H., Yoo S. K., Jee S. H., Kim J. et al. The association between pulse wave velocity and metabolic syndrome in Korean // Disabil Rehabil Assist Technol. 2013. Vol. 8, N 2. P. 140–144.
8. Иваненко В. В. Взаимосвязь показателей жесткости сосудистой стенки с различными сердечно-сосудистыми факторами риска / В. В. Иваненко, О. П. Ротарь, А. О. Конради // Артериальная гипертензия. – 2009. – Т. 15, № 3. – С. 290–295.
9. Кузнецов А. А. Современные показатели жесткости артериальной стенки / А. А. Кузнецов [и др.] // Атеросклероз. – 2011. – Т. 7, № 1. – С. 30–34.
10. Кузнецов А. А. Некоторые детерминанты показателя артериальной жесткости – радиального индекса аугментации / А. А. Кузнецов [и др.] // Бюл. СО РАМН. – 2011. – Т. 31, № 5. – С. 68–71.
11. Weng C., Yuan H., Tang X. Age- and gender dependent association between components of metabolic syndrome and subclinical arterial stiffness in a Chinese population // Int. J. Med. Sci. 2012. Vol. 9, N 8. P. 730–737.
12. Kim Y. K. Impact of the metabolic syndrome and its components on pulse wave velocity // Korean. J. Intern. Med. 2006. Vol. 21, N 2. P. 109–115.
13. Hwang I. C., Suh S. Y., Seo A. R. Association between Metabolic Components and Subclinical Atherosclero-sis in Korean Adults // Korean. J. Fam. Med. 2012. Vol. 33, N 4. P. 229–236.
14. Aznaouridis K., Vlachopoulos C., Dima I. Triglyceride level is associated with wave reflections and arterial stiffness in apparently healthy middle-aged men // Heart. 2007. Vol. 93, N 5. P. 613–614.
15. Khadilkar A. V., Chiplonkar S. A., Pandit D. S. Metabolic risk factors and arterial stiffness in Indian children of parents with metabolic syndrome // J. Am. Coll. Nutr. 2012. Vol. 31, N 1. P. 54–62.
16. Daskalova D. C., Kolovou G. D., Panagiotakos D. B. Increase in aortic pulse wave velocity is associated with abnormal postprandial triglyceride response // Clin Cardiol. 2005. Vol. 28, N 12. P. 577–583.
Review
For citations:
Kuznetsov A.A., Khristoforov K.N., Sukhanov A.V., Ragino Yu.I., Ivanova M.V., Duma S.N., Gafarov V.V., Voevoda M.I. Association of arterial stiffness with components of metabolic syndrome. Ateroscleroz. 2013;9(2):29-32. (In Russ.)
Views:
111
Email this article 