Cardiotonic properties of high density lipoproteins
Abstract
The ability of rat plasma high density lipoproteins (HDLs) to increase the frequency and amplitude of isolated rat heart contraction without considerable increase of oxygen consumption was revealed in Langendorf model. 30 min perfusion of solution with adrenalin in the regime of recirculation diminished the contractility of myocardium and increased heart oxygen consumption. The addition of HDLs in the perfusion solution protected the heart from the negative adrenalin action. The established inotropic effects of HDLs may have various mechanisms and make high density lipoproteins pоssible candidates for the endogenous digitalis-like compounds.
About the Authors
L. E. PaninRussian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Biochemistry"
630117
st. Timakova, 2
Novosibirsk
A. R. Kolpakov
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Biochemistry"
630117
st. Timakova, 2
Novosibirsk
R. A. Knyazev
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Biochemistry"
630117
st. Timakova, 2
Novosibirsk
N. I. Tsirelnikov
Russian Federation
SB RAMS
Federal State Budgetary Institution "Research Institute of Biochemistry"
630117
st. Timakova, 2
Novosibirsk
References
1. Климов А. Н. Обмен липидов и липопротеидов и его нарушения. Руководство для врачей / А. Н. Климов, Н. Г. Никульчева. – СПб.: Питер, 1999. – 505 с.
2. Panin L. E., Maksimov V. F., Usynin I. F., Korostyshevskaya I. M. Activation of nuclear DNA expression in hepatocytes by glucocorticoids and high density lipoproteins // J. Steroid Biochem. Mol. Biol. 2002. Vol. 81. P. 69–76.
3. Gomaraschi M., Calabresi L., Rossoni G. et al. Antiinflammatory and cardioprotective activities of synthetic high-density lipoprotein containing apolipoprotein A-I mimetic peptides // J. Pharmacol. Exp. Ther. 2008. Vol. 324, N 2. P. 776–783.
4. Панин Л. Е. Биохимические механизмы стресса / Л. Е. Панин. – Новосибирск: Наука, 1983. – 234 с.
5. Panin L. E., Maksimov V. F., Usynin I. F., Korostyshevskaya I. M. Activation of DNA expression in hepatocytes by glucocorticoids and high density lipoproteins // J. Steroid Biochem Mol. Biol. 2002. Vol. 81. P. 69–76.
6. Панин Л. Е. Влияние адреналина и кортикостерона на захват и распределение атерогенных и антиатерогенных липопротеинов в миокарде / Л. Е. Панин [и др.] // Пробл. эндокринологии. – 2004. – Т. 50, № 5. – С. 45–48.
7. Calabresi L., Rossoni G., Gomaraschi M. et al. High-density lipoproteins protect isolated rat hearts from ischemia-reperfusion injury by reducing cardiac tumor necrosis factor-alpha content and enhancing prostaglandin release // Circ. Res. 2003. Vol. 92, N 3. P. 330–337
8. Rossoni G., Gomaraschi M., Berti F. et al. Synthetic high-density lipoproteins exert cardioprotective effects in myocardial ischemia / reperfusion injury // J. Pharmacol. Exp. Ther. 2004. Vol. 308, N 1. P. 79–84.
9. Gomaraschi M., Calabresi L., Rossoni G. et al. Antiinflammatory and cardioprotective activities of synthetic high-density lipoprotein containing apolipoprotein A-I mimetic peptides // J. Pharmacol. Exp. Ther. 2008. Vol. 324, N 2. P. 776–783.
10. Wang T. D., Lee C. M., Wu C. C. et al. The effects of dyslipidemia on left ventricularsystolic function in patients with stable angina pectoris // Atherosclerosis. 1999. Vol. 146. P. 117–124.
11. Алюхин Ю. С. Энергетика сердца и температурная адаптация организма / Ю. С. Алюхин // Физиол. журн. СССР им. И. М. Сеченова. – 1975. – T. 16, № 5. – C. 749–757.
12. Havel R. J., Eder H. H., Bragdan J. N. The distribution and composition of centrifugally ceparated lipoproteins in human serum // J. Clin. Invest. 1955. Vol. 34, N 7. P. 1345–1353.
13. Тузиков Ф. В. Определение фракционного и субфракционного состава липопротеинов крови методом малоуглового рентгеновского рассеяния (сравнение с биохимическим методом) / Ф. В. Тузиков [и др.] // Вопр. мед. химии. – 2002. – Т. 48, № 1. – С. 84–93.
14. Zannad F., Graham C. W., Aronson J. K. The effects of digoxin and dopamine on the oxygen consumption, lactate production and haemodynamic performance of an isolated, perfused, working guinea-pig heart // Eur. J. Pharmacol. 1982. Vol. 81, N 2. P. 263–271.
15. Zhang Q., Meng Z. The inotropic effects of ammonia on isolated perfused rat hearts and the mechanisms involved // J. Exp. Biol. 2011. Vol. 214, Pt 23. P. 4048–4054.
16. Bian J. S., Yong Q. C., Pan T. T. et al. Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes // J. Pharmacol. Exp. Ther. 2006. Vol. 316, N 2. P. 670–678.
17. Huang M. H., Wang H. Q., Roeske W. R. et al. Mediating delta-opioid-initiated heart protection via the beta2-adrenergic receptor: role of the intrinsic cardiac adrenergic cell // Am. J. Physiol. Heart Circ. Physiol. 2007. Vol. 293, N 1. P. 376–384.
18. Sakakibara M., Ogawa Uchida A. Syntheses of (14β,15β,16β,17α)- and (14β,15α,16α,17α)-1,3,5(10)-estratriene-2,3,14,15,16,17-hexaols, pоssible candidates for the Inagami–Tamura endogenous-like factor, and their activity // Biosci. Biotech. Biochem. 1996. Vol. 60, N 3. P. 405–410.
19. Szokodi I., Kinnunen P., Tavi P. et al. Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide // Circulation. 1998. Vol. 97. P. 1062–1070
20. Webb A., Bond R., McLean P. et al. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage // Proc. Natl. Acad. Sci. USA. 2004. Vol. 101, N 37. P. 13683–13688.
21. Penna C., Alloatti G., Cappello S. et al. Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation // Am. J. Physiol. Heart Circ. Physiol. 2005. Vol. 288, N 5. P. 2512–2520.
22. Szokodi I., Tavi P., Fцldes G. et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility // Circ. Res. 2002. Vol. 91, N 5. P. 434–440.
23. Ramacotti C., Sharkey A., McClellant G., Winegardt S. Endothelial cells regulate cardiac contractility (endothelium/endothelial factors/cardiac energetics / cardiac autoregulation) // Proc. Natl. Acad. Sci. USA. 1992. Vol. 89. P. 4033–4036.
24. Панин Л. Е. Проникновение липопротеинов и аполипопротеинов очень низкой плотности в миокард и изменения его структуры при перфузии сердца крыс in vitro / Л. Е. Панин [и др.] // Вестн. АМН. – 2004. – № 7. – С. 254–259.
25. Bellosta S., Gomaraschi M., Canavesi M. et al. Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection // FEBS Lett. 2006. Vol. 580, N 25. P. 5974–5978.
26. Gomaraschi M., Calabresi L., Rossoni G. et al. Antiinflammatory and cardioprotective activities of synthetic high-density lipoprotein containing apolipoprotein A-I mimetic peptides // J. Pharmacol. Exp. Ther. 2008. Vol. 324, N 2. P. 776–783.
27. Панин Л. Е. Особенности взаимодействия кортизола, тетрагидрокортизола и их комплексов с аполипопротеином АI с эукариотической ДНК / Л. Е. Панин [и др.] // Молекуляр. биология. – 1998. – T. 32, № 3. – С. 447–451.
28. Панин Л. Е. Энергетические аспекты адаптации / Л. Е. Панин. – Л.: Медицина, 1978. – 192 с.
29. Mineo Ch., Shaul P. W. Novel biological functions of high-density lipoprotein cholesterol // Circ. Res. 2012. Vol. 111. P. 1079–1090.
30. Вотчал Б. Е. Очерки клинической фармакологии / Б. Е. Вотчал. – М.: Медицина, 1963. – 492 с.
Review
For citations:
Panin L.E., Kolpakov A.R., Knyazev R.A., Tsirelnikov N.I. Cardiotonic properties of high density lipoproteins. Ateroscleroz. 2013;9(2):5-10. (In Russ.)