Preview

Ateroscleroz

Advanced search

Role of microalbuminuria for inhospital event risk assessment after coronary artery bypass surgery

Abstract

undergoing coronary artery bypass surgery (CABG). The course of perioperative period in 719 patients undergoing CABG in the Research Institute for Complex Issues of Cardiovascular Diseases between March, 2011 and April, 2012 was evaluated. All the patients had creatinine concentrations, glomerular filtration rate (GFR by MDRD) and daily urine microalbumin levels measured before CABG and at day 7 after CABG. Major event rates were assessed (myocardial infarction, stroke or transient ischemic attack, acute or decompensated chronic renal failure or remediastinotomy) during the hospital stay. The EuroSCORE was calculated for each patient. Different EuroSCORE risk patients had similar serum creatinine levels while microalbumin concentrations in daily urine were significantly higher in moderate and high EuroSCORE risk groups before the surgery as compared to low-risk patients. Patients who experienced postoperative events had significantly higher microalbuminuria both before and after surgery while there were no differences in such renal dysfunction markers as creatinine and GFR. Preoperative microalbuminuria assessment can act as a marker of complicated postoperative period after CABG.

About the Authors

K. S. Shafranskaja
RAMS
Russian Federation

SB RAMS

Federal State Budgetary Institution "Research Institute of Complex Problems of Cardiovascular Diseases"

650002

Pine Boulevard, 6

Kemerovo

 



A. A. Kuzmina
RAMS
Russian Federation

SB RAMS

Federal State Budgetary Institution "Research Institute of Complex Problems of Cardiovascular Diseases"

650002

Pine Boulevard, 6

Kemerovo



D. A. Sumin
RAMS
Russian Federation

SB RAMS

Federal State Budgetary Institution "Research Institute of Complex Problems of Cardiovascular Diseases"

650002

Pine Boulevard, 6

Kemerovo



K. V. Kamlenok
Russian Ministry of Health
Russian Federation

State educational institution of higher professional education "Kemerovo State Medical Academy"

650056

st. Voroshilov, 22A

Kemerovo



K. E. Krivoshapova
Russian Ministry of Health
Russian Federation

State educational institution of higher professional education "Kemerovo State Medical Academy"

650056

st. Voroshilov, 22A

Kemerovo



V. V. Kalaeva
RAMS
Russian Federation

SB RAMS

Federal State Budgetary Institution "Research Institute of Complex Problems of Cardiovascular Diseases"

650002

Pine Boulevard, 6

Kemerovo



M. V. Evseeva
Russian Ministry of Health
Russian Federation

State educational institution of higher professional education "Kemerovo State Medical Academy"

650056

st. Voroshilov, 22A

Kemerovo



O. L. Barbarash
RAMS
Russian Federation

SB RAMS

Federal State Budgetary Institution "Research Institute of Complex Problems of Cardiovascular Diseases"

650002

Pine Boulevard, 6

Kemerovo



L. S. Barbarash
RAMS
Russian Federation

SB RAMS

Federal State Budgetary Institution "Research Institute of Complex Problems of Cardiovascular Diseases"

650002

Pine Boulevard, 6

Kemerovo



References

1. Авалиани В. М. Особенности аортокоронарного шунтирования у больных системным атеросклерозом / В. М. Авалиани. – Архангельск, 2007. – 223 с.

2. Зыков М. В. Значимость мультифокального атеросклероза для модификации шкалы риска отдаленной смертности GRACE у больных острым коронарным синдромом с подъемом сегмента ST / М. В. Зыков [и др.] // Атеросклероз. – 2012. – Т. 8, № 1. – С. 14–21.

3. Methodology manual and policies from the ACCF // AHA Task Force on Practice Guidelines. 2010 Jun. 88 p. American College of Cardiology Foundation and American Heart Association, Inc.

4. Шафранская К. С. Возможность использования модифицированной шкалы EUROSCORE для оценки годового прогноза коронарного шунтирования у пациентов с мультифокальным атеросклерозом / К. С. Шафранская [и др.] // Патология кровообращения и кардиохирургия. – 2010. – № 2. – С. 52–56.

5. Klausen K. P., Scharling H., Jensen J. S. Very low level of microalbuminuria is associated with increased risk of death in subjects with cardiovascular or cerebrovascular diseases // Intern. Med. J. 2006. Vol. 260 (3). P. 231–237.

6. Nilsson J., Algotsson L., Höglund P. et al. Comparison of 19 pre-operative risk stratification models in open-heart surgery // Eur Heart. J. 2006. N 27. P. 867–874.

7. Go A. S., Chertow G. M. Fan D. et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization // N. Engl. J. Med. 2004. Vol. 351. P. 1296–1305.

8. Резниченко Н. Е. Уровень цистатина С независимо связан с риском развития неблагоприятного исхода у лиц, перенесших обострение ишемической болезни сердца и имеющих нормальную или незначительно сниженную функцию почек / Н. Е. Резниченко [и др.] // Кардиология. – 2011. – № 6. – C. 4–10.

9. Haase M., Bellomo R., Devarajan P. et al. Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in a adults // Ann. Thorac. Surg. 2009. Vol. 88. P. 124–133.

10. Thakar C. V., Worley S., Arrigain S. et al. Influence of renal dysfunction on mortality after cardiac surgery: Modifying effect of preoperative renal function // Kidney Int. 2005. Vol. 67. P. 1112–1119.

11. Uchino S. Serum creatinine // Curr. Opin. Crit. Care 2010. (in this issue).

12. Chertow G. M., Soroko S. H., Paganini E. P. et al. Mortality after acute renal failure: Models for pro-gnostic stratification and risk adjustment // Kidney Int. 2006. Vol. 70. P. 1120–1126.

13. Ермоленко В. М. Острая почечная недостаточность / В. М. Ермоленко, А. Ю. Николаев. – М.: «ГОЭТАР-МЕД», 2010. – 240 c.

14. Рекомендации по профилактике, диагностике и лечению артериальной гипертензии. Российские рекомендации (второй пересмотр) // Кардиоваск. тер. профилактика. – 2008. – 4 (Приложение).

15. Хирманов В. Н. Фактор риска: микроальбуминурия / В. Н. Хирманов // Терапевт. арх. – 2004. – № 9. – C. 78–84.

16. Gosling P., Czyz J., Nightingale P., Manji M. Microalbuminuria in the intensive care unit: Clinical correlates and association with outcomes in 431 patients // Crit. Care. Med. 2006. Vol. 34, N 8. Р. 2158–2166.


Review

For citations:


Shafranskaja K.S., Kuzmina A.A., Sumin D.A., Kamlenok K.V., Krivoshapova K.E., Kalaeva V.V., Evseeva M.V., Barbarash O.L., Barbarash L.S. Role of microalbuminuria for inhospital event risk assessment after coronary artery bypass surgery. Ateroscleroz. 2013;9(1):21-28. (In Russ.)

Views: 156


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2078-256X (Print)
ISSN 2949-3633 (Online)