INFECTIONS, INFLAMMATION AND ATHEROSCLEROSIS
https://doi.org/10.15372/ATER20190211
Abstract
Atherosclerotic cardiovascular diseases are the leading cause of death worldwide. In recent decades, the influence of many microorganisms involved (directly or indirectly) in provoking the process of atherogenesis, including cell adhesion, cytokine-associated damage, release of reactive oxygen species, etc. has been shown. Others, such as the influenza virus, can cause systemic inflammation that can damage vascular wall (for example, by cytokines and proteases). In addition, another indirect mechanism by which some infectious agents (such as Helicobacter pylori, Chlamydia pneumoniae, periodontal pathogens, etc.) that may play a role in the pathogenesis of atherosclerosis is molecular mimicry. Given the complexity of the mechanisms by which each pathogen can contribute to the development and progression of atherosclerosis, it is obvious that ongoing research and new data will be useful for improving our understanding of the infectious component of atherosclerosis.
About the Authors
O. V. Reshetnikov
Research Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS
Russian Federation
Russian Federation
S. A. Kurilovich
Research Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS; Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Yu. P. Nikitin
Research Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS
Russian Federation
Russian Federation
References
1. Campbell L.A., Rosenfeld M.E. Infection and atherosclerosis development // Arch. Med. Res. 2015. Vol. 46. P. 339–350.
2. O’Connor S., Taylor C., Campbell L.A. et al. Potential infectious etiologies of atherosclerosis: a multifactorial perspective // Emerg. Infect. Dis. 2001. Vol 7. P. 780–788.
3. Rosenfeld M.E., Campbell L.A. Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosis // Thromb. Haemost. 2011. Vol. 106. P. 858–867.
4. Org E., Mehrabian M., Lusis A.J. Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota // Atherosclerosis. 2015. Vol. 241 (2). P. 387–399.
5. Fabricant C.G., Fabricant J., Litrenta M.M., Minick C.R. Virus-induced atherosclerosis // J. Exp. Med. 1978. Vol. 148 (1). P. 335–340.
6. Никитская Е.А., Марюхнич Е.В., Саввинова П.П. и др. Вирусы герпеса человека и атеросклероз. Современный взгляд // Креатив. кардиология. 2015. ¹ 2. С. 54–62.
7. Grivel J.C., Ivanova O., Pinegina N., Blank P.S., Shpektor A., Margolis L.B., Vasilieva E. Activation of T lymphocytes in atherosclerotic plaques // Arterioscler. Thromb. Vasc. Biol. 2011. Vol. 31, 12. P. 2929–2937.
8. Никитская Е.А., Гривель Ж.-Ш., Иванова О.И. и др. Исследование герпес-вирусной ДНК в коронарных артериях пациентов, умерших в острой стадии инфаркта миокарда // Креатив. кардиология. 2014. ¹ 4. С. 52–64.
9. Тарасов А.В., Куляшова Л.Б., Желтакова И.Р. и др. Особенности диагностики инфекции, вызванной Chlamydophila pneumoniae, у больных острым коронарным синдромом // Инфекция и иммунитет. 2016. Т. 6, ¹ 1. С. 67–72.
10. Almalki Z.S., Guo J.J. Cardiovascular events and safety outcomes associated with azithromycin therapy: a meta-analysis of randomized controlled trials // Am. Health. Drug. Benefits. 2014. Vol. 7 (6). P. 318–328.
11. Govea-Alonso D.O., Beltrán-López J., SalazarGonzález J.A., Vargas-Morales J., Rosales-Mendoza S. Progress and future opportunities in the development of vaccines against atherosclerosis // Expert. Rev. Vaccines. 2017. Vol. 16, No. 4. P. 337–350. DOI: 10.1080/14760584.2017.1258309.
12. Yu M., Zhang Y., Yang Z. et al. Association between Helicobacter pylori infection and stroke: a meta-analysis of prospective observational studies // J. Stroke. Cerebrovasc. Dis. 2014. Vol. 23, N 9. P. 2233–2239.
13. Huang W.S., Tseng C.H., Lin C.L. et al. Helicobacter pylori infection increases subsequent ischemic stroke risk: a nationwide population-based retrospective cohort study // QJM. 2014. Vol. 107, N. 12. P. 969–975.
14. Sharma V., Aggarwal A. Helicobacter pylori: Does it add to risk of coronary artery disease // World. J. Cardiol. 2015. Vol. 7, N 1. P. 19–25.
15. Vijayvergiya R., Vadivelu R. Role of Helicobacter pylori infection in pathogenesis of atherosclerosis // World. J. Cardiol. 2015. Vol. 7, N 3. P. 134–143.
16. Chmiela M., Gajewski A., Rudnicka K. Helicobacter pylori vs coronary heart disease - searching for connections // World. J. Cardiol. 2015. Vol. 7, N 4. P. 187–203.
17. Решетников О.В., Курилович С.А., Никитин Ю.П. Инфекции пародонта и их возможное влияние на развитие атеросклероза и его осложнений // Атеросклероз. 2015. Т. 11, ¹ 1. С. 74–80.
18. Chistiakov D.A., Orekhov A.N., Bobryshev Y.V. Links between atherosclerotic and periodontal disease // Exp. Mol. Pathol. 2016. Vol. 100. P. 220–235.
19. Chou S.H., Tung Y.C., Lin Y.S. et al. Major adverse cardiovascular events in treated periodontitis: a population-based follow-up study from Taiwan // PLoS. One. 2015. Vol. 10, N 6. e0130807.
20. Bokhari S.A., Khan A.A., Butt A.K. et al. Periodontitis in coronary heart disease patients: strong association between bleeding on probing and systemic biomarkers // J. Clin. Periodontol. 2014. Vol. 41, N 11. P. 1048–1054.
21. Orlandi M., Suvan J., Petrie A. et al. Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis // Atherosclerosis. 2014. Vol. 236, N 1. P. 39–46.
22. Chukkapalli S.S., Rivera-Kweh M.F., Velsko I.M. et al. Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers // FEMS. Pathogens. Disease. 2015. Vol. 73, N 3. P. 1–12
23. Решетников О.В., Курилович С.А., Никитин Ю.П. Возможная роль вируса гриппа при атеросклерозассоциированных заболеваниях: насколько эффективна превенция? // Атеросклероз. 2012. Т. 8, ¹ 1. С. 27–35
24. Veljkovic V., Glisic S., Veljkovic N. et al. Influenza vaccine as prevention for cardiovascular diseases: possible molecular mechanism // Vaccine. 2014. Vol. 32. P. 6569–6575.
25. Ватутин Н.Т., Калинкина Н.В., Лагутенкова О.И., Шевелек А.Н. Поражение сердечно-сосудистой системы при ВИЧ-инфекции // Сердце и сосуды. 2013. Т. 4, ¹ 44. С. 116–122.
26. Barakat M.G., Arora R.R. Coronary artery disease in the human immunodeficiency virus seropositive population // Am. J. Ther. 2016. Vol. 23, N 1. P. e224e231. DOI: 10.1097/MJT.0b013e3182973924.
27. Domont F., Cacoub P. Chronic hepatitis C virus infection, a new cardiovascular risk factor? // Liver. Int. 2016. Vol. 36, N 5. P. 621–627. DOI: 10.1111/ liv.13064.
28. Sullivan Z.A., Wong E.B., Ndung’u T. et al. Latent and active tuberculosis infection increase immune activation in individuals co-infected with HIV // EBio. Med. 2015. Vol. 2, N 4. P. 334–340.
29. Chung W.S., Lin C.L., Hung C.T. et al. Tuberculosis increases the subsequent risk of acute coronary syndrome: a nationwide population-based cohort study // Int. J. Tuberc. Lung. Dis. 2014. Vol. 18, N 1. P. 79–83.
30. Sessa R., Pietro M.D., Filardo S., Turriziani O. Infectious burden and atherosclerosis: A clinical issue // World. J. Clin. Cases. 2014. Vol. 2, N 7. P. 240– 249.
31. Kountouras J., Polyzos S.A., Zeglinas C., Katsinelos P. Helicobacter pylori-related chronic hepatitis C infection and the risk for cardiovascular disease // Liver. Int. 2016. May 13. doi: 10.1111/liv.13161.
32. Elkind M.S. Infectious burden: a new risk factor and treatment target for atherosclerosis // Infect. Disord. Drug. Targets. 2010. Vol. 10, N 2. P. 84–90.
33. Thomas G.S., Wann L.S., Allam A.H. et al. Why did ancient people have atherosclerosis?: from autopsies to computed tomography to potential causes // Glob. Heart. 2014. Vol. 9, N 2. P. 229–237.
34. Finch C.E. Evolution of the human lifespan, past, present, and future: phases in the evolution of human life expectancy in relation to the inflammatory load // Proc. Am. Philos. Soc. 2012. Vol. 156, N 1. P. 9–44.
35. Lathe R., Sapronova A., Kotelevtsev Y. Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature // BMC. Geriatrics. 2014. Vol. 14. P. 36.
36. Magen E., Bychkov V., Ginovker A., Kashuba E. Chronic Opisthorchis felineus infection attenuates atherosclerosis – an autopsy study // Int. J. Parasitol. 2013. Vol. 43, N 10. P. 819–824.
Review
For citations:
Reshetnikov O.V., Kurilovich S.A., Nikitin Yu.P. INFECTIONS, INFLAMMATION AND ATHEROSCLEROSIS. Ateroscleroz. 2019;15(2):78-88. (In Russ.) https://doi.org/10.15372/ATER20190211
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