CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION
https://doi.org/10.15372/ATER20190203
Abstract
In this paper we thought to investigate clinical value of tissue inhibitor of metalloproteinase-1 (TIMP-1) in predicting left ventricular (LV) myocardial remodeling in patients having Q-wave myocardial infarction (Q-wave MI). We demonstrated that TIMP-1 serum level clearly corresponds to degree of postinfarction LV myocardial remodeling. In patients who had serum concentrations of TIMP-1 over the established cut-off value (144.0 ng/ml), the risk of post-infarction LV remodeling was 3.33 times higher than in individuals who had TIMP-1 levels lower this value. Thus, TIMP-1 is a reliable prediction biomarker of adverse left ventricular myocardial remodeling in Q-wave MI.
About the Authors
A. S. Vorobyev
Surgut State University; District Cardiology Clinic Center of Diagnostics and Cardiovascular Surgery
Russian Federation
Russian Federation
L. V. Kovalenko
Surgut State University
Russian Federation
Russian Federation
K. Yu. Nikolaev
Surgut State University; Research Institute of Internal and Preventive Medicine – Branch of Federal Research Institute of Cytology and Genetics of SB RAS
Russian Federation
Russian Federation
I. A. Urvantseva
Surgut State University; District Cardiology Clinic Center of Diagnostics and Cardiovascular Surgery
Russian Federation
Russian Federation
T. О. Simonyan
Surgut State University
Russian Federation
Russian Federation
М. I. Rudenko
Surgut State University
Russian Federation
Russian Federation
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Review
For citations:
Vorobyev A.S., Kovalenko L.V., Nikolaev K.Yu., Urvantseva I.A., Simonyan T.О., Rudenko М.I. CLINICAL PREDICTIVE VALUE OF TISSUE INHIBITOR OF METALLOPROTEINASE-1 IMYOCARDIAL REMODELING DEVELOPMENT IN PATIENTS HAVING Q-WAVE MYOCARDIAL INFARCTION. Ateroscleroz. 2019;15(2):17-23. (In Russ.) https://doi.org/10.15372/ATER20190203
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