Comparison of risk factors for arterial hypertension in a cohort of young adults aged 25–44 years over a 10-year period
https://doi.org/10.52727/2078-256X-2026-22-2-225-233
Abstract
The aim of the study was to determine the difference between risk factors associated with high blood pressure in Novosibirsk residents aged 25–44 years, based on survey data conducted in 2013-2016 and 10 years later in 2023–2024. Material and methods. The study included residents of Novosibirsk aged 25–44 years, surveyed in 2013–2016 and in 2023–2024 in the NIITPM branch of the ICiG SB RAS – 211 people (46 % of men, 54 % of women). Results. In people 35–54 years of age, hypertension is directly associated with age (OR = 1,095, 95 % CI 1,029–1,165, p = 0.004), male gender (OR = 3,627, 95 % CI 1,847– 7,122, p = 0.001), waist circumference (OR = 2,781, 95 % CI 1,400–5,524, p = 0.004) as well as with molecular factors – hyperglycemia (OR = 2.352, 95 % CI 1.250–4.427, p = 0.008), hypertriglyceridemia (OR = 3.892, 95 % CI 1.686–8.982, p = 0.001), total cholesterol (OR = 1.366, 95 % CI 1.027–1.818, p = 0.032). Conclusions. The data obtained suggest that age, male gender, increased visceral fat, and impaired lipid metabolism are the leading risk factors for increased blood pressure at a young age.
Supporting agencies: The work was performed within the framework of the State assignment under the budgetary theme of the research work No. FWNR-2024-0004.
About the Authors
S. R. Ledovskikh
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Sofia R. Ledovskikh, postgraduate student, research associate of the laboratory of genetic and environmental determinants of the human life cycle
175/1, Boris Bogatkov st., Novosibirsk, 630089
L. V. Shcherbakova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Lilia V. Shcherbakova, senior researcher, laboratory of clinical and population and preventive studies of therapeutic and endocrine diseases
175/1, Boris Bogatkov st., Novosibirsk, 630089
D. V. Denisova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Diana V. Denisova, doctor of medical sciences, chief researcher, head of the laboratory of preventive medicine
175/1, Boris Bogatkov st., Novosibirsk, 630089
O. V. Pushkina
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Olga V. Pushkina, doctor of clinical laboratory diagnostics, employee of the laboratory of clinical, biochemical, hormonal studies of therapeutic diseases
175/1, Boris Bogatkov st., Novosibirsk, 630089
Yu. I. Ragino
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Yulia I. Ragino, doctor of medical sciences, professor, corresponding member of the RAS, head of the IIPM – Branch of ICiG SB RAS
175/1, Boris Bogatkov st., Novosibirsk, 630089
References
1. Franklin S.S., Lopez V.A., Wong N.D., Mitchell G.F., Larson M.G., Vasan R.S., Levy D. Single versus combined blood pressure components and risk for cardiovascular disease: the Framingham Heart Study. Circulation. 2009 Jan 20; 119 (2): 243–250. doi: 10.1161/CIRCULATIONAHA.108.797936
2. Erina A.M., Rotar O.P., Orlov A.V., Solntsev V.N., Shalnova S.A., Deev A.D., Baranova E.I., Konradi A.O., Chazova I.E., Boytsov S.A., Shlyakhto E.V. Prehypertension and cardiometabolic risk factors (data of the ESSE-RF study). Arterial’naya gipertenziya – Arterial Hypertension. 2017; 23 (3): 243– 252. doi: 10.18705/1607-419X-2017-23-3-243-252 (In Russ.).
3. Aidarbek A.B., Dauyrbay Zh.N., Zhanbyrbai D.B., Sailau N.O., Yesenbek A.M., Abikulova A.K. Prevalence of risk factors of arterial hypertension in young people. Bulletin of KazNMU. 2020; № 3 (In Russ.).
4. Fomin I.V., Polyakov D.S., Badin Yu.V., Belen kov Yu.N., Mareev V.Yu., Ageev F.T. et al. Arterial Hypertension in the European Part of the Russian Federation from 1998 to 2007: What Have We Achieved at the Population Level? Heart: A Journal for Practicing Physicians. 2016; 15 (5): 369–78. (In Russ.).
5. Ledovskikh S.R., Shcherbakova L.V., Denisova D.V., Shramko V.S., Pushkina O.V., Ragino Yu.I. Factors associated with the presence of high blood pressure in people younger than 45 years old. Ateroscleroz. 2025; 21 (2): 156–165. (In Russ.).
6. Authors/Task Force Members; ESC Committee for Practice Guidelines (CPG); ESC National Cardiac Societies. 2019ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk. Atherosclerosis. 2019; 290: 140–205. doi: 10.1016/j.atherosclerosis.2019.08.014
7. Karamnova N.S., Rytova A.I., Shvabskaya O.B., Ma karov Yu.K., Maksimov S.A., Balanova Yu.A., Evstifeeva S.E., Imaeva A.E., Kapustina A.V., Muromtseva G.A., Shalnova S.A., Drapkina O.M. Associations of Dietary Habits and Alcohol Consumption with Cardiovascular Diseases and Diabetes Mellitus in the Adult Population. Results of the ESSE-RF Epidemiological Study. Cardiovascular Therapy and Prevention. 2021; 20 (5): 2982. doi:10.15829/1728-8800-2021-2982 (In Russ.).
8. D’Agostino R.B.Sr., Vasan R.S., Pencina M.J., Wolf P.A., Cobain M., Massaro J.M., Kannel W.B. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation. 2008 Feb 12; 117 (6): 743–753. doi: 10.1161/CIRCULATIONAHA.107.699579
9. Barmagambetova A.T. Prevalence of Arterial Hypertension in Kazakhstan and Abroad. Bulletin of KazNMU. 2013; 1. ISSN 2524-0692 (online). (In Russ.).
10. Nechaeva G.I., Korennova O.Yu., Bulakhova E.Yu., Kozyreva V.A., Kurochkina S.D. Optimization of Treatment of Arterial Hypertension in Young People with a Burdened Family History. RMJ. 2008; 5: 293. (In Russ.).
11. Hardy S.T., Holliday K.M., Chakladar S. et al. Heterogeneity in blood pressure transitions over the life course: age-specific emergence of racial/ethnic and sex disparities in the United States. JAMA Cardiol. 2017; 2: 653–661. doi: 10.1001/jamacardio.2017.0652
12. Philbois S.V., Facioli T.P., Gastaldi A.C. et al. Important differences between hypertensive middle-aged women and men in cardiovascular autonomic control-a critical appraisal. Biol Sex Differ. 2021; 12: 11. doi:10.1186/s13293-020-00355-y
Review
For citations:
Ledovskikh S.R., Shcherbakova L.V., Denisova D.V., Pushkina O.V., Ragino Yu.I. Comparison of risk factors for arterial hypertension in a cohort of young adults aged 25–44 years over a 10-year period. Ateroscleroz. 2026;22(2):225-233. (In Russ.) https://doi.org/10.52727/2078-256X-2026-22-2-225-233
Views:
25
JATS XML
Email this article 
