Associations of serum adipokines and metabolic hormones with metabolic indices in abdominal obesity
https://doi.org/10.52727/2078-256X-2026-22-1-60-72
Abstract
The aim – to identify associations of serum adipokines and metabolic hormones with metabolic indices in abdominal obesity.
Material and methods. 151 people aged 25–65 years were included in the study. Questionnaires, anthropometry, blood pressure measurements, and fasting venous blood sampling were performed. The parameters of the lipid profile and glucose in the blood were determined using enzymatic methods. Multiplex analysis was used to determine the level of the following adipokines and metabolic hormones in the blood: adiponectin, adipsin, lipocalin-2, plasminogen activator type 1 inhibitor (PAI-1), resistin, amylin, C-peptide, ghrelin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), glucagon, insulin, pancreatic polypeptide (PP), peptide YY (PYY), interleukin-6 (IL-6), leptin, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), secretin.
Results. An inverse relationship was found between elevated TyG, LAP, and TG/HDL-C indices and serum adiponectin levels, elevated LAP and VAI indices directly depended on serum leptin levels, and an increase in the LAP index ≥ 32 was directly associated with the concentration of serum PAI-1 and C-peptide.
Supporting agencies: The study was carried out within the framework of the budget topic under State Assignment No. FWNR-2024-0004.
About the Authors
O. V. Tuzovskaya
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Olga V. Tuzovskaya, research assistant, laboratory of genetic and environmental determinants of the human life cycle
175/1, Boris Bogatkov st., Novosibirsk, 630089
L. V. Shcherbakova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Lilia V. Shcherbakova, senior researcher at the laboratory of clinical-population and preventive research of therapeutic and endocrine diseases
175/1, Boris Bogatkov st., Novosibirsk, 630089
Ya. V. Polonskaya
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Yana V. Polonskaya, doctor of biological sciences, senior researcher, laboratory of clinical biochemical and hormonal studies on internal diseases
175/1, Boris Bogatkov st., Novosibirsk, 630089
E. V. Kashtanova
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena V. Kashtanova, doctor of biological sciences, head of the laboratory, laboratory of clinical biochemical and hormonal studies on internal diseases
175/1, Boris Bogatkov st., Novosibirsk, 630089
Yu. I. Ragino
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Yulia I. Ragino, D.Sc. (Biology), corresponding member of the Russian Academy of Sciences, head
175/1, Boris Bogatkov st., Novosibirsk, 630089
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For citations:
Tuzovskaya O.V., Shcherbakova L.V., Polonskaya Ya.V., Kashtanova E.V., Ragino Yu.I. Associations of serum adipokines and metabolic hormones with metabolic indices in abdominal obesity. Ateroscleroz. 2026;22(1):60-72. (In Russ.) https://doi.org/10.52727/2078-256X-2026-22-1-60-72
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