Associations of depression with candidate genes associated with atherosclerosisdependent cardiovascular diseases among individuals aged 25–64

The aim of the study: to identify the most significant associations of depression with candidate genes associated with atherosclerosis-related cardiovascular diseases among individuals aged 25–64 in Novosibirsk. Material and methods. The study of the association of candidate genes with depression in the population of individuals aged 25–64 years in Novosibirsk was carried out using the material of three large-scale epidemiological studies in which residents of the Oktyabrsky district of Novosibirsk participated. This study included: III screening of the WHO MONICA psychosocial program in 1994–1995 (657 men); IV screening “HAPIEE” 2003–2005 (642 men); VI screening of the population in 2013–2017 (403 men and 531 women). Genotyping of the studied polymorphisms was carried out in the laboratory of molecular genetic studies of the Research Institute of Therapeutic Microbiology and Microbiology, branch of the Institute of Cytology and Genetics (Novosibirsk). Results. A reliable association was found between depression and carriage of the following genotypes: SLA and LALA of the SLC6A4 gene, “long” alleles (6 repeats and higher) of the DRD4 gene, 9/9 of the SLC6A3 gene, T/C genotype of the DRD2/ANKK1 Taq1A gene, G/G of the COMT gene, C/G of the IL-6 gene, G/A of the TNF-α gene and ε3/4 of the APOE gene (p < 0.05). Conclusions. The demonstration of a common genetic substrate for depression and atherosclerosis-related cardiovascular diseases may further reveal the bidirectional mechanisms by which depression and cardiovascular diseases potentiate each other.

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