Cardiometabolic risk factors and osteoporotic fractures in people aged over 50 years (Novosibirsk)

Aim. To study the associations between cardiometabolic risk factors (CRF) and osteoporotic fractures (OF) in a population sample aged over 50 years.
Materials and methods. The cross-sectional study was based on Russian part of the HAPIEE Project (Novosibirsk, 2003–2005). This analysis included 7363 men and women 50–69 years old. We collected information on the OF over the past 12 months using a standard questionnaire, we assessed socio-demographic parameters and the main CRF (obesity, hyperglycemia, dyslipidemia, menopause duration in women, smoking, alcohol consumption), and taking of hormone replacement therapy in postmenopausal women. The analysis of associations between CRF and the chance of OF was performed.
Results. The frequency of OF over the past 12 months was 3.6 % (3.2 % in men and 4.0 % in women, p = 0.074). The risk of fracture was directly associated with blood pressure, HDL cholesterol, and ethanol consumption of more than 30 g per 1 session, and it was inversely associated with BMI among men. In women, the chance of a fracture was directly associated with current smoking, an increase in the menopause duration and inversely associated with TG level independent of other factors.
Conclusion. Among the examined persons over 50 years of age, we reveled the syndemia of CRF in relation to OF risk in men, the chance of OF has positive association with an increase of blood pressure and HDL-C levels, ethanol consumption of more than 30 g per session and negative association with BMI value; in women, the chance of fracture positively associated with current smoking, postmenopausal duration, and negatively associated with TG level, regardless of other factors. The data obtained make it possible to speak of significant links between CRF and OF.

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