Genetics of longevity: telomere length of leukocytes as a marker of aging and a risk factor for age-related diseases in humans
Abstract
The manuscript is devoted to review in the area of genetics of longevity (current state of knowledge), in particular, the use of leukocyte telomere length measurement as a marker of aging and as an indicator of the risk for age-related diseases in humans. The paper also gives an overview of laboratory methods to assess telomere length. In the frame of pilot study of the project on biomarkers of «biological age» in Russian population (grant RCSF) the method for analysis of telomeres length by real-time PCR on the base of technique by Cawthon (2002) was tested. The results of testing provided required accuracy, reproducibility of method’s was of 95,5 %, the tried and tested technique will be used for analysis in present project.
About the Authors
V. N. Maksimov
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
E. N. Voropaeva
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
M. Bobak
University College London
United Kingdom
United Kingdom
1–19 Torrington Place
London
S. K. Malyitina
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
M. I. Voevoda
RAMS
Russian Federation
Russian Federation
SB RAMS
Research Institute of Internal and Preventive Medicine
630089
Boris Bogatkov str., 175/1
Novosibirsk
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Review
For citations:
Maksimov V.N., Voropaeva E.N., Bobak M., Malyitina S.K., Voevoda M.I. Genetics of longevity: telomere length of leukocytes as a marker of aging and a risk factor for age-related diseases in humans. Ateroscleroz. 2014;10(4):5-9. (In Russ.)
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