aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАН10.15372/ATER20180311ateroskleroz-85Research ArticleОБЗОРЫREVIEWSPCSK9: НОВЫЕ ПОБЕДЫ И ГОРИЗОНТЫPCSK9: NEW VICTORY AND HORIZONSСмолинаМ. О.SmolinaM. O.mary_mosk@mail.ruБенимецкаяК. С.BenimetskayaK. S.astramedicina@mail.ruРагиноЮ. И.RaginoYu. I.ragino@mail.ruВоеводаМ. И.VoevodaM. I.mvoevoda@ya.ruНИИТПМ - филиал ИЦиГ СО РАНInstitutе of Internal and Preventive Medicine - Вranch of Federal Research Institute of Cytology and Genetics of SB RAS2018270920191437077Copyright © Смолина М.О., Бенимецкая К.С., Рагино Ю.И., Воевода М.И., 20192019Смолина М.О., Бенимецкая К.С., Рагино Ю.И., Воевода М.И.Smolina M.O., Benimetskaya K.S., Ragino Y.I., Voevoda M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/85

В обзоре представлены последние данные мировой научной литературы о клинических исследованиях, посвященных ингибиторам пропротеинконвертазы субтилизин/кексин 9 типа (PCSK9). Представлены результаты важнейших завершенных клинических исследований и анонсы перспективных клинических исследований, завершение которых ожидается в ближайшее время. Освещено место ингибиторов PCSK9 в современных рекомендациях Европейского и Российского кардиологических обществ. Приведены результаты исследований эффективности и безопасности ингибиторов PCSK9 у отдельных групп пациентов (семейная гиперхолестеринемия, гипертриглицеридемия). Дан обзор исследований, направленных на поиск новых механизмов ингибирования PCSK9, открывающих новые горизонты в лечении пациентов с дислипидемией.

The review presents the latest data from the world scientific literature of clinical studies of inhibitors protoprotein convertasesubtilisin/kexin 9 type (PCSK9). The results of the most important completed clinical trials and announcements of prospective clinical trials are presented, the completion of which is expected in the near future. The place of PCSK9 inhibitors in modern recommendations of the European and Russian Cardiological Society is highlighted.The results of studies on the efficacy and safety of PCSK9 inhibitors in selected patient groups (familial hypercholesterolemia, hypertriglyceridemia) are presented. A review of the research aimed at finding new inhibition mechanisms for PCSK9, opening new horizons in the treatment of patients with dyslipidemia.

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The authors declare that there are no conflicts of interest present.