References

ateroskleroz

Атеросклероз

Ateroscleroz

2078-256X2949-3633

НИИТПМ-филиал ИЦиГ СО РАН

ateroskleroz-699

Research Article

ОБЗОРЫ

REVIEWS

Клеточные аспекты патогенеза хронических неинфекционных заболеваний

Сell aspects of chronic noninfectious diseases pathogenesis

Никитин

Ю. П.

Nikitin

Yu P.

Юрий Петрович Никитин, д-р мед. наук, проф., академик, заслуженный деятель науки РФ, зав. лабораторией

СО РАМН

ФГБУ «НИИ терапии и профилактической медицины»

лаборатория этиопатогенеза и клиники внутренних заболеваний

630089

ул. Бориса Богаткова, 175/1

Новосибирск

SB RAMS

Research Institute of therapy Internal and preventive medicine

630089

Boris Bogatkov str., 175/1

Novosibirsk

Воробьева

Е. Н.

Vorobyova

E. N.

Елена Николаевна Воробьева, д-р мед. наук, проф., зав. лабораторией

ГБОУ ВПО «Алтайский государственный медицинский университет»

кафедра биохимии и клинической лабораторной диагностики

Алтайская лаборатория эпидемиологии, прогнозирования и профилактики ХНИЗ

656049

ул. Ленина, 40

СО РАМН

ФГБУ «НИИ терапии и профилактической медицины»

Алтайская лаборатория эпидемиологии, прогнозирования и профилактики хронических неинфекционных заболеваний

Алтайский край

Барнаул

656049

Lenin str., 40

Barnaul

Симонова

Г. И.

Simonova

G. I.

Галина Ильинична Симонова, д-р мед. наук, проф., зав. лабораторией, научный руководитель лабаратории

СО РАМН

ФГБУ «НИИ терапии и профилактической медицины»

лаборатория клинико-популяционных и профилактических исследований терапевтических и эндокринных заболеваний

630089

ул. Бориса Богаткова, 175/1

Новосибирск

656049

ул. Ленина, 40

Алтайский край

Барнаул

SB RAMS

Research Institute of therapy Internal and preventive medicine

630089

Boris Bogatkov str., 175/1

656049

Lenin str., 40

Barnaul

Research Institute of therapy

Novosibirsk

Воробьев

Р. И.

Vorobyov

R. I.

Роман Иосифович Воробьев, канд. мед. наук, врач-кардиолог

ФГБУ «НИИ терапии и профилактической медицины»

656049

ул. Ленина, 40

Алтайский край

Барнаул

Altai laboratory of epidemiology, prognosis and prevention

656049

Lenin str., 40

Barnaul

Казызаева

А. С.

Kazyzaeva

A. S.

Анна Сергеевна Казызаева, канд. биол. наук, доцент

ГБОУ ВПО «Алтайский государственный медицинский университет»

кафедра гигиены и основ экологии человека

656049

ул. Ленина, 40

Алтайский край

Барнаул

656049

Lenin str., 40

Barnaul

РАМНRAMS

Минздрав России; РАМНAltai State Medical University; Research Institute of therapy

РАМН; КГБУЗ «Городская больница № 1»Research Institute of therapy

Минздрав РоссииAltai State Medical University

2014

10042022

1015666

2022

Никитин Ю.П., Воробьева Е.Н., Симонова Г.И., Воробьев Р.И., Казызаева А.С.

Nikitin Y.P., Vorobyova E.N., Simonova G.I., Vorobyov R.I., Kazyzaeva A.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://ateroskleroz.elpub.ru/jour/article/view/699

Кавеолы – это инвагинации плазматической мембраны большинства дифференцированных клеток. Они особенно обильны в эндотелиальных клетках, адипоцитах, миоцитах и фибробластах. Мембрана кавеол обогащена холестерином, сфинголипидами и их обязательным структурным белковым компонентом – кавеолинами (1, 2 и 3). В многочисленных исследованиях была продемонстрирована важная роль кавеол и кавеолинов в различных функциях клетки, включая процессы эндоцитоза, гомеостаз липидов, сигнальную трансдукцию и онкосупрессию. Выведение кавеолиндефицитных мышей позволило анализировать функции кавеол и кавеолинов в отношении физиологии человека. В последние годы накапливаются доказательства вовлечения кавеолинов в патогенез заболеваний человека, включая атеросклероз, сахарный диабет 2 типа, рак, мышечные дистрофии и др. В обзоре описана роль кавеол и кавеолинов в норме и патологии.

Caveolae are plasma membrane invaginations of the majority of differentiated cells. They are especially abundant in endothelial cells, adipocytes, muscle cells, and fibroblasts. Caveolae membrane is enriched in cholesterol, sphingolipids, and their principal structural protein component caveolins (1, 2, and 3). In numerous studies caveolae and caveolins important role in a variety of cellular functions including endocytic processes, lipid homeostasis, signal transduction, and tumor suppression was demonstrated. Generation of caveolindeficient mice allowed to analyze functions of caveolae and caveolins with respect to human physiology. In the recent years evidences of caveolins implicating in the pathogenesis of human diseases, including atherosclerosis, diabetes type 2, cancer, muscular dystrophies are accumulated. In a review the role of caveolae and caveolins in health and disease is described.

атеросклерозкавеолыкавеолин-1плазматическая мембрана

atherosclerosiscaveolaecaveolin-1plasma membrane

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The authors declare that there are no conflicts of interest present.