aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАНateroskleroz-685Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESАссоциации вариабельности объема эритроцитов с клинико- лабораторными характеристиками острого инфаркта миокардаAssociations of red cell distribution width with clinical and laboratory characteristics of acute myocardial infarctionУрванцеваИ. А.UrvantsevaI. A.

Ирина Александровна Урванцева, канд. мед. наук, главный врач

628400

ул. Губкина, 1

628400

st. Gubkina, 1

priem@okd.ruНиколаевК. Ю.NikolaevK. Yu.

Константин Юрьевич Николаев, д-р мед. наук, зав. лабораторией, проф., проф. кафедры

СО РАМН

ФГБУ «НИИ терапии и профилактической медицины»

кафедра внутренних болезней

630089

ул. Бориса Богаткова, 175/1

630090

ул. Пирогова, 2

Новосибирск

SB RAMS

Federal state budgetary institution "Research Institute of Therapy and Preventive Medicine"

630089

st. Boris Bogatkov, 175/1

630090

st. Pirogova, 2

Novosibirsk

nikolaevky@yandex.ruСаламатинаЛ. В.SalamatinaL. V.

Людмила Викторовна Саламатина, д-р мед. наук, проф., зав. лабораторией

проблемная научно-исследовательской лаборатория

628400

ул. Губкина, 1

628400

st. Gubkina, 1

salamatina@okd.ruСеитовА. А.SeitovA. A.

Алексей Александрович Сеитов, зав. отделением

отделение неотложной кардиологии

628400

ул. Губкина, 1

628400

st. Gubkina, 1

МиловановаЕ. В.MilovanovaE. V.

Елена Владимировна Милованова, зав. отделением

отделение функциональной диагностики

628400

ул. Губкина, 1

628400

st. Gubkina, 1

НиколаеваА. А.NikolaevaA. A.

Алевтина Андреевна Николаева, д-р мед. наук, проф., главный научный сотрудник

СО РАМН

ФГБУ «НИИ терапии и профилактической медицины»

630089

ул. Бориса Богаткова, 175/1

Новосибирск

SB RAMS

Federal state budgetary institution "Research Institute of Therapy and Preventive Medicine"

630089

st. Boris Bogatkov, 175/1

Novosibirsk

nikolaev@sibmail.ruБУ ХМАО – Югры Окружной кардиологический диспансер «Центр диагностики и сердечно-сосудистой хирургии»Budget institution of the Khanty Mansiysk Autonomous Okrug - Ugra District Cardiology Dispensary Center for Diagnostics and Cardiovascular SurgeryРАМН; ФГБОУ «Новосибирский национальный исследовательский государственный университет»RAMS; Federal State Budgetary Educational Institution "Novosibirsk National Research State University"РАМНRAMS20130904202293-43137Copyright © Урванцева И.А., Николаев К.Ю., Саламатина Л.В., Сеитов А.А., Милованова Е.В., Николаева А.А., 20222022Урванцева И.А., Николаев К.Ю., Саламатина Л.В., Сеитов А.А., Милованова Е.В., Николаева А.А.Urvantseva I.A., Nikolaev K.Y., Salamatina L.V., Seitov A.A., Milovanova E.V., Nikolaeva A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/685

   Вариабельность объема эритроцитов (RDW) – показатель неоднородности размеров эритроцитов – является новым предиктором прогноза инфаркта миокарда (ИМ). Целью данного исследования стала оценка ассоциаций вариабельности объема эритроцитов с клинико-лабораторными показателями и гендерными характеристиками у пациентов с острым ИМ. Обследовано 250 пациентов (208 мужчин и 42 женщины) с ИМ и подъемом сегмента ST. Уровень RDW определялся при проведении автоматизированного общего анализа крови. Не выявлено различий в уровнях RDW у мужчин и женщин с ИМ. Ряд ассоциаций был обнаружен между RDW и атеросклерозом сонных артерий (r = +0,156, p = 0,013), хронической анемией (r = +0,155, p = 0,014), наличием онкологического заболевания (r = +0,178, p = 0,005), плеврального выпота (r = +0,153, p = 0,015), тромбоза левого желудочка (r = +0,133, p = 0,036), острой энцефалопатии (r = +0,178, p = 0,005), лейкоцитами (r = +0,132, p = 0,037), тромбоцитами (r = +0,195, p = 0,002) и натрием (r = –0,232, p = 0,006). По результатам ковариационного анализа выявлено, что наиболее значимая ассоциация RDW была с плевральным выпотом. Эта ассоциация отражает влияние воспаления на осложнения при ИМ.

   Red cell distribution width (RDW), a measure of circulating erythrocyte size heterogeneity, is a new predictor of myocardial infarction (MI) prognosis. The aim of this study is to evaluate the associations of RDW with clinical and laboratory parameters and gender characteristics of patients with acute myocardial infarction. A total of 250 patients (208 male and 42 female) with an ST elevation acute MI were examined. The RDW level was measured with an automated complete blood count. It did not differ in levels of RDW between male and female with MI. Series of associations were detected between RDW and carotid atherosclerosis (r = +0.156, p = 0.013), chronic anemia (r = +0.155, p = 0.014), with the presence of cancer (r = +0.178, p = 0.005), pleural effusion (r = +0.153, p = 0.015), thrombosis of the left ventricle (r = +0.133, p = 0.036), acute encephalopathy (r = +0.178, p = 0.005), leukocytes (r = +0.132, p = 0.037), platelet (r = +0.195, p = 0.002), and sodium (r = –0.232, p = 0.006). The most significant association of RDW with pleural effusion was detected according to the results of covariance analysis. This association has reflected influence of inflammation to complications acute MI.

инфаркт миокардавариабельность объема эритроцитовосложненияmyocardial infarctionred cell distribution widthcomplicationsReferencesUyarel H., Ergelen M., Cicek G. et al. Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction // Coron. Artery Dis. 2011. Vol. 22, N 3. P. 138–144.Uyarel H., Ergelen M., Cicek G. et al. Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction // Coron. Artery Dis. 2011. Vol. 22, N 3. P. 138–144.Sangoi M. B., da Silva S. H., da Silva J. E., Moresco R. N. Relation between red blood cell distribution width and mortality after acute myocardial infarction // Am. J. Cardiol. 2010. Vol. 105, N 3. P. 313–317.Sangoi M. B., da Silva S. H., da Silva J. E., Moresco R. N. Relation between red blood cell distribution width and mortality after acute myocardial infarction // Am. J. Cardiol. 2010. Vol. 105, N 3. P. 313–317.Lippi G., Targher G., Montagnana M. et al. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients // Arch. Path. ol Lab. Med. 2009. Vol. 133. P. 628–632.Lippi G., Targher G., Montagnana M. et al. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients // Arch. Path. ol Lab. Med. 2009. Vol. 133. P. 628–632.Bessman J. D., Gilmer P. R. Jr., Gardner F.H. Improved classification of anemias by MCV and RDW // Am. J. Clin. Pathol. 1983. Vol. 80. P. 322–326.Bessman J. D., Gilmer P. R. Jr., Gardner F.H. Improved classification of anemias by MCV and RDW // Am. J. Clin. Pathol. 1983. Vol. 80. P. 322–326.Patel K. V., Semba R. D., Ferrucci L. et al. Red cell distribution width and mortality in older adults: A meta-analysis // J. Gerontol. A. Biol. Sci. Med. Sci. 2010. Vol. 65. P. 258–265.Patel K. V., Semba R. D., Ferrucci L. et al. Red cell distribution width and mortality in older adults: A meta-analysis // J. Gerontol. A. Biol. Sci. Med. Sci. 2010. Vol. 65. P. 258–265.Montagnana M., Cervellin G., Meschi T., Lippi G. The role of red blood cell distribution width in cardiovascular and thrombotic disorders // Clin. Chem. Lab. Med. 2012. Vol. 50. P. 635–641.Montagnana M., Cervellin G., Meschi T., Lippi G. The role of red blood cell distribution width in cardiovascular and thrombotic disorders // Clin. Chem. Lab. Med. 2012. Vol. 50. P. 635–641.Allen L. A., Felker G. M., Mehra M. R. et al. Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure // J. Card. Fail. 2010. Vol. 16. P. 230–238.Allen L. A., Felker G. M., Mehra M. R. et al. Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure // J. Card. Fail. 2010. Vol. 16. P. 230–238.Dabbah S., Hammerman H., Markiewicz W., Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction // Am. J. Cardiol. 2010. Vol. 105, N 3. P. 312–317.Dabbah S., Hammerman H., Markiewicz W., Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction // Am. J. Cardiol. 2010. Vol. 105, N 3. P. 312–317.Wen Y. High red blood cell distribution width is closely associated with risk of carotid artery atherosclerosis in patients with hypertension // Exp. Clin. Cardiol. 2010. Vol. 15, N 3. P. 37–40.Wen Y. High red blood cell distribution width is closely associated with risk of carotid artery atherosclerosis in patients with hypertension // Exp. Clin. Cardiol. 2010. Vol. 15, N 3. P. 37–40.Ekelund L.-G., Moberg A., Olsson A. G., Oro L. Recent myocardial infarction and the conduction system. A clinico-pathological correlation // British Heart Jour nal. I972. Vol. 34. P. 774–780.Ekelund L.-G., Moberg A., Olsson A. G., Oro L. Recent myocardial infarction and the conduction system. A clinico-pathological correlation // British Heart Jour nal. I972. Vol. 34. P. 774–780.López-Cuenca A., Manzano-Fernández S., Lip G. Y. H. et al. Interleukin-6 and High-sensitivity C-reactive Protein for the Prediction of Outcomes in Non-ST-segment Elevation Acute Coronary Syndromes // Rev. Esp. Cardiol. 2013. Vol. 66. P. 185–192.López-Cuenca A., Manzano-Fernández S., Lip G. Y. H. et al. Interleukin-6 and High-sensitivity C-reactive Protein for the Prediction of Outcomes in Non-ST-segment Elevation Acute Coronary Syndromes // Rev. Esp. Cardiol. 2013. Vol. 66. P. 185–192.Fornal M., Wizner B., Cwynar M. et al. Association of red blood cell distribution width, inflammation mar kers and morphological as well as rheological erythrocyte parameters with target organ damage in hypertension // Clin. Hemorheol. Mictocirc. 2013. May 29.Fornal M., Wizner B., Cwynar M. et al. Association of red blood cell distribution width, inflammation mar kers and morphological as well as rheological erythrocyte parameters with target organ damage in hypertension // Clin. Hemorheol. Mictocirc. 2013. May 29.Senol K., Saylam B., Kocaay F., Tez M. Red cell distribution widt has a predictor of mortality in acute pancreatitis // Am. J. Emerg. Med. 2013. Vol. 31, N 4. P. 687–689.Senol K., Saylam B., Kocaay F., Tez M. Red cell distribution widt has a predictor of mortality in acute pancreatitis // Am. J. Emerg. Med. 2013. Vol. 31, N 4. P. 687–689.Tonelli M., Sacks F., Arnold M., Moye L. et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease // Circulation. 2008. Vol. 117, N 2. P. 163–168.Tonelli M., Sacks F., Arnold M., Moye L. et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease // Circulation. 2008. Vol. 117, N 2. P. 163–168.Ozkalemkas F., Ali R., Ozkocaman V. et al. The bone marrow aspirate and biopsy in the diagnosis of unsuspected nonhematologic malignancy: a clinical study of 19 cases // BMC Cancer. 2005. Vol. 5. P. 144.Ozkalemkas F., Ali R., Ozkocaman V. et al. The bone marrow aspirate and biopsy in the diagnosis of unsuspected nonhematologic malignancy: a clinical study of 19 cases // BMC Cancer. 2005. Vol. 5. P. 144.Karabulut A., Uyarel H., Uzunlar B., Çakmak M. Elevated red cell distribution width level predicts worse postinterventional thrombolysis in myocardial infarction flow reflecting abnormal reperfusion in acute myocardial infarction treated with a primary coronary intervention // Coron. Artery Dis. 2012. Vol. 23, N 1. P. 68–72.Karabulut A., Uyarel H., Uzunlar B., Çakmak M. Elevated red cell distribution width level predicts worse postinterventional thrombolysis in myocardial infarction flow reflecting abnormal reperfusion in acute myocardial infarction treated with a primary coronary intervention // Coron. Artery Dis. 2012. Vol. 23, N 1. P. 68–72.

The authors declare that there are no conflicts of interest present.