aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАН10.15372/ATER20180107ateroskleroz-67Research ArticleОБЗОРЫREVIEWSИЗМЕНЕНИЯ ЛИПИДОМА ПРИ КОЛОРЕКТАЛЬНОМ РАКЕCHANGES OF LIPIDOM IN COLORECTAL CANCERКручининаМ. В.KruchininaM. V.kruchmargo@yandex.ruГромовА. А.GromovA. A.gromovcenter@rambler.ruПрудниковаЯ. И.PrudnikovaIa. I.dr.prudnikova@mail.ruКручининВ. Н.KruchininV. N.kruch@isp.nsc.ruШашковМ. В.ShashkovM. V.shashkov@catalysis.ruСидельниковВ. Н.SidelnikovV. N.sidelnikov@catalysis.ruСоколоваА. С.SokolovaA. S.asokolova@nioch.nsc.ruСалахутдиновН. Ф.SalakhutdinovN. F.anvar@nioch.nsc.ruНИИ терапии и профилактической медицины - филиал ИЦиГ СО РАНInstitute of Internal and Preventive Medicine - Branch of Federal Research Institute of Cytology and Genetics of SB RASФГБУН Институт физики полупроводников им. А.В. Ржанова СО РАНRzhanov Institute of Semiconductor Physics SB RASФГБУН Институт катализа им. Г.К. Борескова СО РАНBoreskov Institute of Catalysis SB RASФГБУН Новосибирский институт органической химии им. Н.Н. Ворожцова СО РАНVorozhtsov Institute of organic chemistry SB RAS2018270920191415064Copyright © Кручинина М.В., Громов А.А., Прудникова Я.И., Кручинин В.Н., Шашков М.В., Сидельников В.Н., Соколова А.С., Салахутдинов Н.Ф., 20192019Кручинина М.В., Громов А.А., Прудникова Я.И., Кручинин В.Н., Шашков М.В., Сидельников В.Н., Соколова А.С., Салахутдинов Н.Ф.Kruchinina M.V., Gromov A.A., Prudnikova I.I., Kruchinin V.N., Shashkov M.V., Sidelnikov V.N., Sokolova A.S., Salakhutdinov N.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/67

Колоректальный рак занимает второе место по смертности среди всех случаев смертности от злокачественных опухолей в мире. Понимание его патофизиологии имеет важное значение для разработки эффективных стратегий лечения этого заболевания. Липидом, совокупность общих липидов, липид-связанных ферментов, рецепторов и сигнальных путей играют важную роль в многочисленных клеточных процессах, таких как обмен веществ, хранение энергии, пролиферация и апоптоз. Нарушения регуляции метаболизма липидов и их функции вносят вклад в развитие и прогрессирование колоректального рака и могут быть использованы для оценки прогноза. По целому перечню направлений дисрегуляция липидного метаболизма при колоректальном раке оказывается сходной с таковой при развитии сердечно-сосудистой патологии. Стратегии, направленные на липидом, были использованы в клинических исследованиях и показали многообещающие результаты. В данном обзоре представлены последние достижения в изучении нарушенного метаболизма липидов при колоректальном раке, механизмы, с помощью которых липидные метаболиты регулируют канцерогенез и прогрессирование опухоли, а также потенциальные терапевтические таргеты для будущих клинических испытаний.

Colorectal cancer is the second cause of death among all deaths, caused by malignant tumors in the world. Understanding its pathophysiology is important for developing effective strategies for treating this disease. Lipidome, a combination of total lipids, lipid-linked enzymes, receptors and signaling pathways play an important role in numerous cellular processes such as metabolism, energy storage, proliferation and apoptosis. The disturbances in the regulation of lipid metabolism and their functions contribute to the development and progression of colorectal cancer and can be used to assess the prognosis. For a whole range of directions, the dysregulation of lipid metabolism in colorectal cancer is similar to that in the development of cardiovascular pathology. Strategies aimed at lipidome have been used in clinical studies and have shown promising results. This review presents recent advances in the study of impaired lipid metabolism in colorectal cancer, the mechanisms by which lipid metabolites regulate carcinogenesis and tumor progression, and potential therapeutic targets for future clinical trials.

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The authors declare that there are no conflicts of interest present.