aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАНateroskleroz-640Research ArticleОБЗОРЫREVIEWSМелатонин, липидный профиль крови и атеросклероз: обзор клинических исследованийMelatonin, serum lipids, and atherosclerosis: a review of clinical studiesДаниленкоК. В.DanilenkoK. V.

Константин Васильевич Даниленко, д-р мед. наук, ведущий научный сотрудник

СО РАМН

ФГБУ «НИИ терапии»

630089

ул. Бориса Богаткова, 175/1

Новосибирск

SB RAMS

Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy

630089

st. Boris Bogatkov, 175/1

Novosibirsk

kvdani@mail.ruРАМНRAMS201203042022813642Copyright © Даниленко К.В., 20222022Даниленко К.В.Danilenko K.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/640

   Приводятся общие сведения о мелатонине – содержании в организме, регуляции секреции, действии. Учитывая антиоксидантные и противовоспалительные свойства мелатонина, выполнен аналитический обзор клинических исследований влияния мелатонина на липидные показатели крови и атеросклероз у человека. Результаты выполненных клинических исследований, в особенности плацебо-контролируемых (4 исследования), не позволяют сделать однозначный вывод об эффективности использования мелатонина для снижения уровня холестерина и нормализации липидного профиля крови.

   The article includes a general information on melatonin – its content in the human body, regulation of secretion, clinical effects. Taking into account the antioxidant and antiinflammatory properties of melatonin, clinical studies of the influence of melatonin on serum lipid profile and atherosclerosis in humans have been reviewed. The results of the clinical studies, particularly of placebo-controlled ones (N=4), appeared to be inconclusive towards the efficacy of melatonin for the lowering of cholesterol levels and normalization of the blood lipid profile.

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The authors declare that there are no conflicts of interest present.