References

ateroskleroz

Атеросклероз

Ateroscleroz

2078-256X2949-3633

НИИТПМ-филиал ИЦиГ СО РАН

ateroskleroz-617

Research Article

ОБЗОРЫ

REVIEWS

Фиброзный процесс при атеросклерозе

Fibrotic process in atherosclerosis

Шварц

Я. Ш.

Shwartz

Ya. Sh.

Яков Шмулевич Шварц, канд. мед. наук, научный сотрудник

СО РАМН

ФГБУ «НИИ терапии»

лаборатория молекулярно-клеточных механизмов терапевтических заболеваний

630089

ул. Бориса Богаткова, 175/1

Новосибирск

SB RAMS

Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy

630089

Boris Bogatkova str., 175/1

Novosibirsk

yshschwartz@mail.ru

Чересиз

Е. А.

Сheresiz

Ye. A.

Екатерина Александровна Чересиз, младший научный сотрудник

СО РАМН

ФГБУ «НИИ терапии»

лаборатория молекулярно-клеточных механизмов терапевтических заболеваний

630089

ул. Бориса Богаткова, 175/1

Новосибирск

SB RAMS

Establishment of the Russian Academy of Medical Sciences Research Institute of Therapy

630089

Boris Bogatkova str., 175/1

Novosibirsk

e.cheresiz@yandex.ru

РАМНРоссияRAMSRussian Federation

2011

31032022

725766

2022

Шварц Я.Ш., Чересиз Е.А.

Shwartz Y.S., Сheresiz Y.A.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://ateroskleroz.elpub.ru/jour/article/view/617

В обзоре приводятся современные представления о вариантах развития атеросклеротического повреждения сосудов, дается описание атерогенеза как хронического воспалительного и фибропластического процесса, характеризуются основные медиаторы и цитокины, участвующие в эволюции атеросклеротической бляшки. Основной акцент делается на роли в атерогенезе взаимоотношений мононуклеарных фагоцитов и клеток-продуцентов соединительной ткани.

In this article up-to-date notions of the variants of atherosclerotic plaque evolution are reviewed, atherogenesis is described as chronic inflammatory and fibrotic process, the major cytokines and mediators involved in the process are characterized. The paper lays special emphasis on the role of interrelationships between mononuclear phagocytes and the extracellular matrix-producing cells.

атеросклерозфиброзмакрофагфибробластгладкомышечная клетка

atherosclerosisfibrosismacrophagefibroblastelissosphincter sell

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The authors declare that there are no conflicts of interest present.