aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАНateroskleroz-580Research ArticleОБЗОРЫREVIEWSЛипопротеид(а) и многоступенчатая атерогенность: коронарный атеросклероз, цереброваскулярные осложнения и другие корреляции Лп(а) и апо(а)Lipoprotein(a) and multi-stage atherogenesis: coronary atherosclerosis, cerebrovascular complications and other correlations of Lp(a) and apo(a)ТихоновА. В.TikhonovA. V.

СО РАМН

Учреждение Российской академии медицинских наук Научно-исследовательский институт терапии

SB RAMS

Research Institute of Therapy

НикитинЮ. П.NikitinYu. P.

СО РАМН

Учреждение Российской академии медицинских наук Научно-исследовательский институт терапии

SB RAMS

Research Institute of Therapy

РАМНRAMS201026032022613442Copyright © Тихонов А.В., Никитин Ю.П., 20222022Тихонов А.В., Никитин Ю.П.Tikhonov A.V., Nikitin Y.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/580

   Доказана связь уровня Лп(а) с наличием и тяжестью атеросклероза магистральных артерий головы. Показано, что у больных с перенесенным инсультом его уровень достоверно выше, чем у лиц групп контроля. Доказана также прямая связь низкомолекулярных фенотипов апо(а) с наличием, тяжестью и развитием атеросклеротического поражения сонных артерий. Повышенное артериальное давление является значимым и независимым фактором риска ишемической болезни сердца (ИБС). Присоединение к артериальной гипертензии других факторов сердечно-сосудистого риска, в том числе нарушений липидного обмена, увеличивает вероятность развития ИБС в еще большей степени.

   A connection of the level of Lp(a) with the presence and extent of atherosclerosis of main arte ries of head was proved. It was demonstrated that this level in the patients who survived stroke is reliably higher than that in the patients from reference groups. A direct connection of low-molecular phe notypes of apo(a) with the presence, extent and development of atherosclerotic affection of carotid arteries was also proved. hypertension is a significant and independent risk factor of coronary heart disease. Other factors of cardiovascular risk including disorders of lipid metabolism, added to arte rial hypertension, increase the probability of the development of coronary heart disease even to the higher extent.

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The authors declare that there are no conflicts of interest present.