aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАНateroskleroz-566Research ArticleСтатьиЛп(а) липопротеид и атеросклерозLipoprotein(a) and atherosclerosisТихоновА. В.TikhonovA. V.

СО РАМН

Научно-исследовательский институт терапии

Новосибирск

SB RAMS

Institute of Internal Medicine

Novosibirsk

РАМНRAMS20072203202231323Copyright © Тихонов А.В., 20222022Тихонов А.В.Tikhonov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/566

   Лп(а) липопротеид является одной из атерогенных форм липопротеидов и был открыт более 45 лет назад. Лп(а) – количественный признак, его концентрация находится под полигенным контролем. Уровень концентрации Лп(а) достоверно ассоциирован с риском развития ИБС и нарушением липидного обмена. При концентрации Лп(а) 5–10 мг/дл риск развития ИБС составлял 8–9 %, при концентрации 14–18 мг/дл – 18–25 %, при 21–28 мг/дл – 25–31 %. Уровень концентрации Лп(а) плазмы крови в популяциях Сибири колеблется от 0 до 80 мг/дл. Уровень концентрации Лп(а) от 5 до 18 мг/дл следует считать условной нормой, а уровень 20 мг/дл и выше – границей риска развития ИБС. Уровень ОХС, ХС ЛПНП во всех обследованных популяциях связан с уровнем концентрации Лп(а) плазмы крови: при 30 мг/дл он достоверно выше по сравнению с концентрацией 14 мг/дл, а при нулевой концентрации – достоверно ниже.

   Lp(a) lipoprotein is one of atherogenic forms of lipoproteins, it was discovered over 45 years ago. Lp(a) is a quantitative feature, its concentration being under polygenic control. The Lp(a) concentration level is significantly associated with the risk of CHD development and lipid methabolic disorders. The risk of CHD development was 8–9 % with Lp(a) concentration of 5–10 mg/dl, 18–25 % with the concentration of 14–18 mg/dl and 25–31 % with that of 21–28 mg/dl. Lp(a) plasma concentration level in the population of Siberia varies from 0 to 80 mg/dl. The Lp(a) concentration level from 5 to 18 mg/dl is to be considered the conventional standard and the level of 20 mg/dl and higher – the border of CHD risk development. The level of total cholesterol and LDL cholesterol in all the populations surveyed is associated with Lp(a) plasma concentration level: with 30 mg/dl it is significantly higher as compared with the concentration of 14 mg/dl, and with “zero” concentration it is significantly lower.

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The authors declare that there are no conflicts of interest present.