aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАН10.52727/2078-256X-2021-17-4-79-92ateroskleroz-548Research ArticleОБЗОРЫREVIEWSСовременные биомаркеры окислительного стресса, оцениваемые методом иммуноферментного анализаModern biomarkers of oxidative stress estimated by immuno-enzymal analysishttps://orcid.org/0000-0003-1973-2618ВолковаМ. В.VolkovaM. V.

Марина Васильевна Волкова, младший научный сотрудник, лаборатория клинических биохимических и гормональных исследований терапевтических заболеваний

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

Marina V. Volkova, junior researcher, laboratory of clinical biochemical and hormonal research of therapeutic diseases

630089, Novosibirsk, Boris Bogatkov str., 175/1

marina_volkova91@mail.ruhttps://orcid.org/0000-0002-4936-8362РагиноЮ. И.RaginoY. I.

Юлия Игоревна Рагино, д-р мед. наук, проф., главный научный сотрудник, лаборатория клинических биохимических и гормональных исследований терапевтических заболеваний

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

Yulia I. Ragino, doctor of medical sciences, professor, chief researcher, laboratory for clinical biochemical and hormonal research of therapeutic diseases

630089, Novosibirsk, Boris Bogatkov str., 175/1

ragino@mail.ruНаучно-исследовательский институт терапии и профилактической медицины – филиал Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»Research Institutе of Internal and Preventive Medicine, Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences2021130120221747992Copyright © Волкова М.В., Рагино Ю.И., 20222022Волкова М.В., Рагино Ю.И.Volkova M.V., Ragino Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/548

В литературном обзоре представлены результаты исследований последних лет, посвященных изучению роли факторов и маркеров окислительного стресса в развитии терапевтических заболеваний, особенно сердечно-сосудистых. Описаны результаты исследований, выполненных с помощью методов иммуноферментного анализа, таких биомаркеров окислительного стресса, как глутатионпероксидаза, супероксиддисмутаза, окислительно модифицированные липопротеины низкой плотности, карбонилированные белки, а также общая антиоксидантная способность крови.

The literature review presents the results of studies carried out in the world over the past years, devoted to the study of factors and markers of oxidative stress in the development of therapeutic diseases, especially cardiovascular diseases. The article describes the results of studies using enzyme immunoassay of such biomarkers of oxidative stress as glutathione peroxidase, superoxide dismutase, oxidatively modified low density lipoproteins, carbonylated proteins, as well as the general antioxidant capacity of the blood.

окислительный стрессбиомаркерыишемическая болезнь сердцасердечно-сосудистые заболеванияглутатионпероксидазасупероксиддисмутазаокислительно-модифицированные липопротеины низкой плотностикарбонилированные белкиобщая антиоксидантная способность кровиантиоксидантыактивированные кислородные метаболитыoxidative stressbiomarkerscoronary heart diseasecardiovascular diseasesglutathione peroxidasesuperoxide dismutaseoxidatively modified low density lipoproteinscarbonylated proteinstotal antioxidant capacity of the bloodantioxidantsactive oxygen metabolitesЛитературный обзор выполнен в рамках бюджетной темы по Государственному заданию № АААА-А19-119101490005-56 и гранта Президента РФ для ведущих научных школ № НШ-2595.2020.7.The literature review was carried out within the framework of the budgetary theme under the State Assignment No. AAAA-A19-119101490005-56 and the grant of the President of the Russian Federation for leading scientific schools No. NSh-2595.2020.7.ReferencesMarrocco I., Altieri F., Peluso I. 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The authors declare that there are no conflicts of interest present.