aterosklerozАтеросклерозAteroscleroz2078-256X2949-3633НИИТПМ-филиал ИЦиГ СО РАНateroskleroz-44Research ArticleОБЗОРЫREVIEWSМОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ МАРКЕРЫ НАРУШЕНИЙ ЛИПИДНОГО ОБМЕНА И ВНЕЗАПНАЯ СЕРДЕЧНАЯ СМЕРТЬMOLECULAR-GENETICAL MARKERS OF LIPID ABNORMALITIES AND SUDDEN CARDIAC DEATHИвановаА. А.IvanovaA. A.ivanova_a_a@mail.ruФГБНУ НИИ терапии и профилактической медициныInstitute of Internal and Preventive Medicine2017270920191323340Copyright © Иванова А.А., 20192019Иванова А.А.Ivanova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ateroskleroz.elpub.ru/jour/article/view/44

Внезапная сердечная смерть продолжает оставаться одной из нерешенных проблем современного здравоохранения. До 50 % летальных исходов вследствие сердечно-сосудистых заболеваний составляет внезапная сердечная смерть, при этом большинство умерших внезапно не имели ранее известного сердечно-сосудистого заболевания. С целью разработки качественной системы диагностики предрасположенности и профилактики развития внезапной сердечной смерти, в первую очередь у лиц без сердечной патологии в анамнезе, исследуются молекулярно-генетические маркеры внезапной сердечной смерти. Одним из факторов риска внезапной сердечной смерти является уровень липидов. В отношении ассоциации с внезапной сердечной смертью изучены однонуклеотидные полиморфизмы генов, ответственных за липидный обмен, таких как CETP, APOE, SREBF2, SCAP, LIPC, USF1, LDLR .

Sudden cardiac death is one of main problem of modern medicine. Sudden cardiac death is about 50 % of all cardiac deaths. The main part of people who died of sudden cardiac death didn’t have any cardiac illnesses. In the world molecular genetic markers of sudden cardiac death are studied to create an effective system of diagnostic of predisposition and prophylactic of sudden deaths, especially to people without cardiac diseases. Lipid abnormalities are one of risk factor of sudden cardiac death. Single nucleotide polymorphisms of CETP, APOE, SREBF2, SCAP, LIPC, USF1, LDLR genes were studied as molecular genetic markers of sudden cardiac death.

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The authors declare that there are no conflicts of interest present.