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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ateroskleroz</journal-id><journal-title-group><journal-title xml:lang="ru">Атеросклероз</journal-title><trans-title-group xml:lang="en"><trans-title>Ateroscleroz</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-256X</issn><issn pub-type="epub">2949-3633</issn><publisher><publisher-name>НИИТПМ-филиал ИЦиГ СО РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52727/2078-256X-2021-17-44-51</article-id><article-id custom-type="elpub" pub-id-type="custom">ateroskleroz-414</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Эффективность проведения кардиобиоуправления у здоровых подростков и подростков с эссенциальной гипертензией</article-title><trans-title-group xml:lang="en"><trans-title>Efficiency of conducting cardiobiofeedback in healthy adolescents and adolescents with essential hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нестерец</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nesterets</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нестерец Алина Михайловна — младший научный сотрудник, сектор изучения моногенных форм распространенных заболеваний Федеральный исследовательский центр «Институт цитологии и генетики»</p><p>630090, г. Новосибирск, просп. Академика Лаврентьева, 10, </p><p>630089, г. Новосибирск, ул. Бориса Богаткова, 175/1 </p></bio><bio xml:lang="en"><p>630090, Novosibirsk, Lavrentiev av., 10,</p><p>630089, Novosibirsk, Boris Bogatkov str., 175/1 </p></bio><email xlink:type="simple">alinvaleeva1994@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сорокин</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sorokin</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сорокин Олег Викторович — кандидат медицинских наук, исполнительный директор</p><p>630108, г. Новосибирск, Пархоменко 1-й пер., 14 </p></bio><bio xml:lang="en"><p>630108, Novosibirsk, 1st lane Parkhomenko, 14 </p></bio><email xlink:type="simple">oleg.sorokin@vedapulse.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нефедова</surname><given-names>Ж. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nefedova</surname><given-names>Zh. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нефедова Жанна Валерьевна — доктор медицинских наук, профессор кафедры пропедевтики детских болезней</p><p>630091, г. Новосибирск, Красный просп., 52 </p></bio><bio xml:lang="en"><p>630091, Novosibirsk, Krasny av., 52 </p></bio><email xlink:type="simple">nefedova_doc@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кайнара</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kainara</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кайнара Виктория Геннадьевна — врач-кардиолог</p><p>630091, г. Новосибирск, Красный просп., 52 </p></bio><bio xml:lang="en"><p>630048, Novosibirsk, Vertkovskaya str., 3 </p></bio><email xlink:type="simple">viktoriya.kajnara@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панасенко</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Panasenko</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Панасенко Людмила Михайловна — доктор медицинских наук, профессор кафедры пропедевтики детских болезней</p><p>630091, г. Новосибирск, Красный просп., 52 </p></bio><bio xml:lang="en"><p>630091, Novosibirsk, Krasny av., 52 </p></bio><email xlink:type="simple">plm-ngmu@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimov</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Максимов Владимир Николаевич — доктор медицинских наук, профессор, заведующий лабораторией молекулярно-­генетических исследований терапевтических заболеваний, НИИТПМ, филиал ФИЦ ИЦиГ СО РАН; профессор кафедры медицинской генетики и биологии медико-профилактичекого факультета, НГМУ</p><p>630090, г. Новосибирск, просп. Академика Лаврентьева, 10, </p><p>630089, г. Новосибирск, ул. Бориса Богаткова, 175/1 </p></bio><bio xml:lang="en"><p>630090, Novosibirsk, Lavrentiev av., 10,</p><p>630089, Novosibirsk, Boris Bogatkov str., 175/1 </p></bio><email xlink:type="simple">Medik11@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ ФИЦ Институт цитологии и генетики СО РАН; &#13;
НИИ терапии и профилактической медицины — филиал ФГБНУ ФИЦ Институт цитологии и генетики СО РАН</institution></aff><aff xml:lang="en"><institution>Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences;&#13;
Research Institute of Internal and Preventive Medicine — Academician Branch of Federal Research Center Institute of Cytology and Genetics of SB RAS</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НКО Национальная аюрведическая медицинская ассоциация</institution></aff><aff xml:lang="en"><institution>NCO National Ayurvedic Medical Association</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО Новосибирский государственный медицинский университет Минздрава России</institution></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ Детская городская клиническая больница № 1</institution></aff><aff xml:lang="en"><institution>City Children Clinical Hospital No.1</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>03</day><month>05</month><year>2021</year></pub-date><volume>17</volume><issue>1</issue><fpage>44</fpage><lpage>51</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нестерец А.М., Сорокин О.В., Нефедова Ж.В., Кайнара В.Г., Панасенко Л.М., Максимов В.Н., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Нестерец А.М., Сорокин О.В., Нефедова Ж.В., Кайнара В.Г., Панасенко Л.М., Максимов В.Н.</copyright-holder><copyright-holder xml:lang="en">Nesterets A.M., Sorokin O.V., Nefedova Z.V., Kainara V.G., Panasenko L.M., Maksimov V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ateroskleroz.elpub.ru/jour/article/view/414">https://ateroskleroz.elpub.ru/jour/article/view/414</self-uri><abstract><sec><title>Введение</title><p>Введение. Рассматривается проблема использования когнитивного висцерального кардиобиоуправления (КБУ) в качестве профилактического и немедикаментозного метода коррекции нарушений механизмов регуляции, связанных с повышением артериального давления у подростков с эссенциальной гипертензией (ЭГ) на фоне стандартной антигипертензивной терапии эналаприлом. Цель исследования — изучить показатели кардиоинтервалограммы (КИГ) в ходе сеанса биологической обратной связи и оценить эффективность КБУ у здоровых подростков и подростков с ЭГ, проживающих в г. Новосибирске.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Каждому участнику проводилась 5-минутная запись КИГ с помощью аппаратно-­программного комплекса «ВедаПульс» в условиях физиологического покоя и при проведении сеанса КБУ, в ходе которого испытуемому предлагалось удлинять фазу экспирации дыхательного цикла с параллельным расслаблением мышечного тонуса и визуальной обратной связью по динамике мультимедийного сюжета, отражающего изменения длительности сердечного цикла.</p><p>Результаты и их обсуждение. Обнаружено, что у здоровых подростков эффективность кардиореспираторной синхронизации характеризуется увеличением показателей SDNN (на 8,3%) и общей мощности спектральных влияний (ТР) (на 23,6%) за счет значительного роста парасимпатического спектрального показателя HF (на 29,4%). Повышение мощности спектра низкочастотных колебаний (LF) на 51,3% может рассматриваться как элемент кардиореспираторной синхронизации в пределах 0,1 Гц. У здоровых подростков сохранена реактивность надсегментарных уровней регуляции (IC) и отмечается их рост на 7,6%. У подростков с ЭГ в процессе КБУ регистрировалось увеличение длительности сердечного цикла на 5,2% и ТР на 31,2%, что связано с усилением мощности спектра высокочастотных колебаний (HF) на 2,4%. Данный феномен следует рассматривать в качестве позитивного патофизиологического отклика вегетативного звена нервной системы, который фиксируется снижением величины артериального давления.</p></sec><sec><title>Заключение</title><p>Заключение. Сделано предположение, что проба с когнитивным висцеральным КБУ может служить эффективным маркером анализа ригидности вегетативных механизмов регуляции у подростков с ЭГ. Сознательная регуляция ритма сердца через механизм управляемого дыхания (биоуправление) может являться эффективным немедикаментозным методом коррекции нарушений вегетативной регуляции у подростков с артериальной гипертензией, что проявляется достоверным снижением артериального давления.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The article discusses the problem of using cognitive visceral cardiobiofeedback as a preventive and non-drug method for correcting disturbed regulation mechanisms associated with an increase in blood pressure in adolescents with essential hypertension (EH) against the background of standard antihypertensive therapy with enalapril. Aim of the study was to investigate the indices of the cardiointervalogram (CIG) during a biofeedback session and to evaluate the effectiveness of cardiobiofeedback in healthy adolescents and adolescents with EH living in Novosibirsk.</p></sec><sec><title>Material and methods</title><p>Material and methods. Each participant underwent a 5-minute CIG recording using the hardware and software complex VedaPulse under physiological rest and during biofeedback session. In the course of biofeedback, the subject was asked to lengthen the expiration phase of the respiratory cycle with parallel relaxation of muscle tone and visual feedback on the dynamics of a multimedia plot reflecting changes in the duration of the cardiac cycle.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. We found that the effectiveness of cardiorespiratory synchronization (CRS) is characterized by an increase in SDNN indicators by 8.3% and the total power of spectral influences (TP) by 23.6% due to a significant increase in the parasympathetic spectral index of HF by 29.4%. An increase in the power index of the spectrum of low-frequency oscillations (LF) by 51.3% can be considered as an element of CRS within 0,1 Hz. In healthy adolescents, the reactivity of the suprasegmental levels of regulation (IC) is preserved and their growth is noted by 7.6%. In adolescents with EH, an increase in the duration of the cardiac cycle by 5.2% and TP by 31.2% was recorded in the course of cardiobiofeedback, which is associated with an increase in the power of the spectrum of high-frequency oscillations (HF) by 2.4%. This phenomenon should be considered as a positive pathophysiological response of the autonomic link of the nervous system, which is recorded by a decrease in blood pressure.</p></sec><sec><title>Conclusion</title><p>Conclusion. We assume that the test with cognitive visceral cardiobiofeedback can serve as an effective marker for the analysis of the rigidity of autonomic mechanisms of regulation in adolescents with essential hypertension. Conscious regulation of the heart rate through the mechanism of controlled respiration (biofeedback) can be an effective non-drug method for correcting autonomic regulation disorders in adolescents with arterial hypertension, which is manifested by a significant decrease in blood pressure.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>подростки</kwd><kwd>кардиоинтервалография</kwd><kwd>кардиореспираторная синхронизация</kwd><kwd>когнитивное висцеральное кардиобиоуправление</kwd><kwd>эссенциальная гипертензия</kwd><kwd>немедикаментозный метод</kwd></kwd-group><kwd-group xml:lang="en"><kwd>adolescents</kwd><kwd>cardiointervalography</kwd><kwd>cardiorespiratory synchronization</kwd><kwd>cognitive visceral cardiobiofeedback</kwd><kwd>essential hypertension</kwd><kwd>non-drug method</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sasaki K., Maruyama R. 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